Peptides

Matches 451 - 500 out of 838	< 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >

Document	Document Title
JP2023518596A	Split inteins and their uses The present invention relates to methods of using engineered split inteins and their combinations with degradation signals (destabilization domains, degrons) to reconstitute large genes for gene therapy.
JP2023515124A	Molecules that target proteins Aspects of the present invention particularly relate to non-naturally occurring molecules capable of down-regulating the amount or biological activity of mutated or variant forms of proteins, as well as applications thereof.
JP2023514068A	Use of anti-aging glycopeptides to suppress immune rejection of grafts The present specification provides gem-difluorinated C-glycopeptide compounds of general formula I, or pharmaceutically acceptable base, acid addition salts, hydrates or hydrates of compounds of general formula I. Disclosed are the uses ...
JP2023513290A	Nanoparticles encapsulating small molecules The present invention relates to a lipoprotein cage for intracellular delivery of cargo, said lipoprotein cage comprising: (i) at least one polypeptide comprising the amino acid sequence I consisting of SEQ ID NO: 1; The protein cage is ...
JP2023510260A	Glycosylation modification using LEISHMANIA cells The present application relates to Leishmania cells genetically engineered to reduce or eliminate O-linked GlcNAc formation on polypeptides in Leishmania cells. In the pre-genetically engineered Leishmania cells, the formation of O-linke...
JP2023509540A	Methods, systems and uses thereof for screening neoantigens It relates to a method, system and use thereof for screening neoantigens, more specifically, the expression is essential for the survival of cancer cells and/or is derived from a gene that is uniform in all cells in cancer tissue. Method...
JP2023509157A	looped protein containing a cell-membrane permeable peptide The present disclosure provides modified looped proteins comprising at least one looped region, wherein at least one looped region comprises a cell membrane penetrating peptide (CPP). In some embodiments, the present disclosure provides ...
JP7232825B2	Microbiota (MICROBIOTA) sequence variants of tumor-associated antigen epitopes The present invention relates to cancer immunotherapy, in particular to sequence variants of tumor-related antigenic epitope sequences. Namely, the present invention provides a method for identification of microbiota sequence variants of...
JP7203729B2	Selective sulfonation of benzodiazepine derivatives The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic agent bearing a maleimide group. In some embodiments, the cell-binding agent ...
JP2022553669A	Methods for obtaining materials from plant cell surfaces The present invention provides a method for exfoliating expressed material from the surface of plant cells or from the apoplast, wherein the plant cells are treated with a rotor-stator in liquid medium and introduced by rotation of the r...
JP2022552598A	Atypical split inteins and their use The present disclosure relates to atypical split N- and C-terminal inteins and variants thereof. The present disclosure also relates to conjugates comprising split N-terminal or C-terminal inteins of the present disclosure and compositio...
JP7187451B2	adenovirus vector The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other t...
JP2022182687A	PEPTIDE COMPOUND To provide a peptide compound containing an optimized peptide ligand having isoquercitrin αvβ5 binding capacity.A peptide compound is represented by the following formula (I). In the formula (I), X1 is a peptide containing amino acid r...
JP2022550991A	Peptide-based cosmetic or dermatological treatment of the skin and its appendages The treatment according to the invention is a compound of the general formula X-(Xaa)nK for non-therapeutic cosmetic treatment of the keratinous tissue of the skin and its appendages.TTKUse of at least one peptide with X'aa-(Xaa)mZ is ...
JP2022171839A	SMALL PEPTIDE-CONTAINING CELL CULTURE MEDIUM To provide: a cell culture medium, a concentrated culture medium, and a concentrated feed material; a method for manufacturing a cell culture medium and a cell culture feed material; and a method for culturing cells.The cell culture medi...
JP2022164689A	MODIFIED κ LIGHT CHAIN-BINDING POLYPEPTIDES To provide a polypeptide with improved alkaline stability.The invention discloses a κ light chain-binding polypeptide comprising a mutated binding domain of Peptostreptococcus Protein L, in which at least one asparagine residue of a par...
JP2022160900A	COMPOUND HAVING PHOTOISOMERIZATION GROUP AND USE THEREOF The present invention discloses a compound represented by the following formula (1). The compound allows control of a metal ion chelating ability by light irradiation. W-(L1)n-X-(L2)m-Y (1). (In the formula (1), X is a photoisomerization...
JP2022542320A	Peptide-loaded carrier system and uses thereof A carrier system comprising a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adapter peptide sequence fused to the N-terminus of the target peptide, and the adapter peptide sequence is d...
JP2022139224A	POLYPEPTIDE FOR CAPTURING TERPENES AND ECGONINE DERIVATIVE, SENSOR AND SYSTEM To provide a polypeptide for detecting terpenes and ecgonine derivative, and a sensor and detection method in which terpenes and ecgonine derivative can be detected with higher sensitivity.A polypeptide according to embodiment is a polyp...
JP2022540096A	Quorum sensing inhibitors and/or postbiotic metabolites and related methods Described herein are synergistic combinations comprising quorum sensing inhibitors and/or postbiotic metabolites and antibiotics. Typically, postbiotic metabolites include at least one peptide. Related compositions, uses, and methods are...
JP2022537331A	Site-specific, kinetically inert conjugation of labels and/or carriers to target molecules such as His-tagged proteins via metal complex reagents The present invention relates to means and methods for conjugating/binding target molecules, such as proteins, to labels and/or carriers. Specifically, the present invention provides (i) CO32-or HCO3-and (ii) a complex comprising a metal...
JP2022537337A	Site-specific, kinetically inert conjugation of labels and/or carriers to target molecules such as His-tagged proteins via metal complex reagents The present invention relates to means and methods for conjugating/binding target molecules, such as proteins, to labels and/or carriers. Specifically, the present invention includes (i) nitrate as the metal cation ligand and (ii) a meta...
JP7118425B2	Peptides and pharmaceutical, nutraceutical, or veterinary compositions for the prevention and/or treatment of hair loss Present invention discloses particular peptide sequences of formula (I); (R1)(m)-Xaa1IXaa2T(Q)(p)(R2)(n)� �� (I) (SEQ ID NO: 1);wherein R1, m, p, n, Xaa1, Xaa2, and R2 have particular meanings, or pharma...
JP2022112031A	ENGINEERED BOTULINUM NEUROTOXINS To provide modified botulinum neurotoxin (BoNT) polypeptides with a modified receptor binding domain of Clostridium botulinum serotype B, comprising one or more substitution mutations at positions corresponding 1248 or 1249 in serotype B...
JP7106560B2	Maytansinoid derivatives with self-sacrificing peptide linkers and their conjugates The invention relates to novel cell-binding agent-maytansinoid conjugate having a self-immolative peptide linker and more specifically to conjugates of formula (I). The invention also provides novel maytansinoid compounds of formula (II)...
JP2022530224A	Cationic polymer with alkyl side chains A polymer containing a hydrolyzable polymer backbone, wherein the polymer backbone has (i) a monomer unit having a side chain containing a hydrophobic group, (ii) a monomer unit having a side chain containing an oligoamine or a polyamine...
JP2022075738A	SOY ALLERGY ANTIGEN To provide a novel soy allergy antigen, a method and a kit for diagnosing allergy to soybeans, a pharmaceutical composition containing the antigen, soybeans or processed soybean products containing no such antigen, and a tester for deter...
JP2022520799A	Prostate-specific membrane antigen (PSMA) ligand with improved tissue specificity The present invention relates to the compound of the formula (1), the complex containing the compound and the radionuclide, and the respective pharmaceutical compositions, wherein the compound has the following structure, or a pharmaceut...
JP2022513575A	Pancreatic Cancer Treatment Compositions and Treatment Aids Containing Alloferone It has been found that the compound of structural formula (1) provides excellent efficacy and the unexpected benefit of reduced side effects in the treatment of cancer. In particular, it showed excellent effects in the adjuvant treatment...
JP2022513326A	Vaccines and methods Described are methods for identifying optimized antigenic pathogen polypeptides capable of inducing a broadened neutralizing immune response against pathogens and associated T cell responses, as well as nucleic acid sequences encoding su...
JP6995371B2	Proteins with repeated sequences of polyamino acids or polypeptides, and chemical synthesis methods thereof The present invention establishes a process for producing a protein using a chemical synthesis method, in particular, using both an enzymatic polymerization method and a block copolymerization method. Provided are: a protein produced by ...
JP6997177B2	SCN9A antisense oligonucleotide The current invention provides peptide nucleic acid derivatives targeting a part of the human SCN9A pre-mRNA. The peptide nucleic acid derivatives potently induce splice variants of the SCN9A mRNA in cells, and are useful to safely treat...
JP2022510606A	Compositions and Methods for Treating Endometriosis A peptide that binds to β-catenin and a composition containing the peptide are provided herein. Peptides that bind to β-catenin prevent translocation to the nucleus and regulate the classical Wnt pathway. Further provided herein are me...
JP2022509184A	Cyclic peptide as a proprotein convertase subbutyricin / kexin type 9 (PCSK9) inhibitor for the treatment of metabolic disorders The present disclosure is an inhibitor of PCSK9 useful in the treatment of lipid metabolism and other diseases in which PCSK9 contributes, having formula (I): [Chemical 1] Or a pharmaceutically acceptable salt, hydrate, solvate, stereois...
JP2022502029A	Barcoded Peptide-MHC Complex and Its Use In certain embodiments, the present disclosure is to (i) screen DNA-barcoded peptides-major histocompatibility complex (pMHC) to detect T lymphocytes specific for these peptides. , And (ii) provide a combination of single-cell sequencing...
JP6989505B2	MALT1 inhibitors and their use Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin' s lymphoma, d...
JP2022500463A	Peptides and their medical uses The present invention relates to peptides, compositions containing such peptides, and their use as inhibitors of angiogenesis and / or angiogenesis. In addition, the invention relates to the use of the peptide and the composition for the...
JP2022500465A	Peptides and their medical uses The present invention relates to peptides, compositions containing such peptides, and their use as inhibitors of angiogenesis and / or angiogenesis. In addition, the invention relates to the use of the peptide and the composition for the...
JP2021193093A	MALT1 INHIBITORS AND USES THEREOF To provide compounds and pharmaceutical compositions thereof which are useful as MALT1 inhibitors.Provided herein are compounds such as benzyl ((S)-1-((S)-2-(((S)-1-fluoro-6-guanidino-2-oxohexan-3-yl)car bamoyl)pyrrolidin-1-yl)-3-methyl-...
JP6984923B2	Pharmaceutical constructs with enhanced binding affinity for albumin The present disclosure provides various molecular constructs having a plurality of fatty acids and a functional element. Methods for treating various diseases using such molecular constructs are also disclosed.
JPWO2020111172A1	Composition for promoting antibacterial peptide production An object of the present invention is to provide a novel material having an infection-preventing effect by increasing the production of antibacterial peptides from epithelial cells. The present invention provides a composition for promot...
JP2021531337A	Self-assembled peptide backbone The present disclosure describes a peptide backbone for producing a vaccine. The peptide backbone contains peptides that self-assemble on a hapten carrier (hC) containing an amphipathic alpha-helix. The peptide contains a 7-residue repea...
JP6959616B2	Site-specific RI-labeled antibody with IgG-binding peptide The present invention relates to an IgG-binding peptide comprising a ligand capable of binding to a radioactive metal nuclide, an IgG-binding peptide labeled with a radioactive metal nuclide, a conjugate of the IgG-binding peptide and Ig...
JP6954843B2	Peptide oligonucleotide conjugate Provided herein are oligonucleotides, peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising a...
JP2021523719A	CCCTC binding factor variant The present invention is an engineered CCCTC binding factor (CTCF) variant comprising at least one amino acid residue in at least one zinc finger that differs from the wild CTCF amino acid sequence, wherein the engineered CTCF variant is...
JP2021520371A	Use of peptides for the treatment of the epidermis Peptides have the general formula X- (Xaa)nKTFK-(Xaa)mHas -Z. Peptides help maintain or improve the condition of the epidermis. In the general formula, K*Is selected from lysine (K), ornithine, diaminobutyric acid or diaminopropionic a...
JP2021118721A	NOVEL PEPTIDES AND COMBINATION OF PEPTIDES AND SCAFFOLDS FOR USE IN IMMUNOTHERAPY FOR VARIOUS CANCERS To provide peptides, proteins, nucleic acids and cells for use in immunotherapy, in particular in cancer immunotherapy.The present invention relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-as...
JPWO2019240288A1	A substance having an affinity for an antibody, and a compound having a bioorthogonal functional group or a salt thereof. The present invention provides techniques that allow antibody modification, in particular regioselective modification of the antibody. More specifically, the present invention describes the following formula (I): ALEB (I) [in the formula...
JP2021105007A	BIOLOGICALLY ACTIVE MOLECULES, CONJUGATES THEREOF, AND THERAPEUTIC USES To provide linker compounds that are useful in covalently linking biologically active molecules with ligands.The present disclosure provides a compound of formula (I) (in the formula, L is a ligand; a is an integer of 1-10; Z2 and Z1 ind...
JP2021093995A	COMPOSITION FOR AMELIORATING OBESITY AND COMPOSITION FOR AMELIORATING TYPE II DIABETES To provide a composition for ameliorating obesity with excellent obesity-ameliorating effect, and a composition for ameliorating type II diabetes with excellent type II diabetes-ameliorating effect.A composition for ameliorating obesity ...

Matches 451 - 500 out of 838	< 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >