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JP4067123B2 |
The present invention relates particularly to neoplastic cells targeted chimeric toxins comprising of cell targeting moieties and cell killing moieties for recognizing and for destroying the neoplastic cells, wherein the cell targeting m...
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JP2008056679A |
To provide a new anti-malignancy polypeptide.Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are provided. The compounds include polypeptides and nucleic acid molecules encoding such peptides....
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JP2008500966A |
The present invention is directed to novel antigens, antibodies and antigen binding fragments thereof, and to immunoassays and kits using these antigens and antibodies. The compositions and methods are useful in the determination of leve...
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JP2008001716A |
To provide reliable diagnostic and prognostic means, a vaccine for prevention and/or treatment of disease, and an immunotherapeutic remedy.A polypeptide containing a newly characterized HCV epitope, a method for producing such a polypept...
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JP2007534297A |
The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled recepto...
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JP2007531705A |
The activity and cell membrane affinity of certain antiviral multiple branch peptide constructions, including those known from WO 95/07929, WO 98/29443 and WO 03/95479, can be improved by bonding to the C-end of the peptide a terminator ...
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JP2007530488A |
The invention provides novel compounds of general formula I wherein R1, R2 and R3 are independently hydrogen, OR4, C1-C6 alkyl or C2-C6 alkenyl, R4 is hydrogen, C1-C6 alkyl or C2-C6 alkenyl, —N-(AA) represents the residue of an amino a...
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JP4001239B2 |
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JP2007528192A |
Isolated polynucleotide (I) comprising a 2630 bp sequence (8; reproduced), and its fragments, are new. Independent claims are also included for: (1) polynucleotide sequences (II) of 41 nucleotides (nt) (4); 38 nt (5); 33 nt (11) and 41 n...
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JP2007525410A |
The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibod...
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JP2007523940A |
The present invention refers to novel antihypertensive peptides which may be used as active ingredients in pharmaceutical preparations, dietary supplements, or as food ingredients. The peptides have/comprise the sequence YGPIPN, or SLPE,...
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JP3926817B2 |
To provide a therapeutic vaccine and an immunotherapeutic drug for reliable diagnosis and prognosis, prophylactic and/or therapy for a disease. The invention relates to a polypeptide containing a newly characterized HCV epitope, and a me...
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JP2007513891A |
The invention provides uses of autophagocytosis inducing compounds for reducing serum levels of triglycerides and VLDL and the preparation of medicaments. The invention also provides the use of autophagocytosis inducing compounds for tre...
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JP3920933B2 |
PURPOSE: To obtain a lowering agent for cholesterol in blood containing a peptide composition, excellent as a proteinic nutrient source and having lowering actions on the cholesterol level in blood without any side effects and toxicity a...
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JP3910569B2 |
To provide a method for searching a natural peptide forming amyloid fiber by a template reaction with a small amount of the nucleus of a fibrillated amyloid β-protein to form amyloid fiber and amplifying the fiber to increase its volume...
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JP2007503810A |
The present disclosure relates to the field of cellular tumorigenesis and cancer biology. More specifically, the present disclosure relates to tumorigenesis and cancer in estrogen-responsive cell types, including cell types such as testi...
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JP2007501948A |
This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, e.g., immunologic, hematologic, vascular, or infectious diseases or conditions, by determining levels of complement pathway c...
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JP3863965B2 |
To obtain the subject new peptide comprising a yolk low-molecular peptide obtained by hydrolyzing a yolk insoluble protein with a protease and useful for an oral intubation liquid diet, sports drink and a food for nutrient supply as a su...
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JP2006527703A |
Preparation containing synthetic peptide combinations for application to humans or animals, wherein the peptide combinations originate from the partial hydrolysis of tissues from the human organism, wherein the peptide combinations are o...
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JP3847092B2 |
The present invention relates to a compound having formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I and pharmaceutical compositions containing them are of the class of thrombin inhibitors which are usef...
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JP2006520912A |
It is to provide a method and a kit for detecting the prognosis of cancer at high accuracy in a simple and rapid manner at low cost. The method is specifically a method for detecting the prognosis of cancer, at least including a step of ...
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JP2006230350A |
To provide a general crystallization method capable of being applied to a wide range of molecules and not based on trials and errors, to provide a crystal crystallized by the method, and to provide a method for solving a phase problem.Th...
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JP2006516885A |
An isolated polypeptide A40926 (I), comprising a polypeptide sequence involved in the biosynthetic pathway of A40926, is chosen from an open reading frame (ORF) polypeptide (II) comprising any one of 37 fully defined sequence such as 366...
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JP3794618B2 |
Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meani...
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JPWO2004076476A1 |
The present invention provides a method for searching for a novel substance that can be used as an initiator of proteoglycan, and for efficiently synthesizing a substance that can be used as such an initiator. The present invention has t...
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JP3753383B2 |
To provide a method for labeling one or the two oxygen atoms of a carboxy group of a carboxylated compound with an oxygen isotope which is either oxygen of mass number 17 (17O) or oxygen of mass number 18 (18O). The method is characteriz...
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JP3725899B6 |
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JP2006504657A |
The present invention relates to a method for the preparation of a compound of formula (I) or pharmaceutically acceptable salts thereof and intermediates thereof, comprising the steps of: a) halogenating a compound of formula (II), resul...
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JPWO2004022744A1 |
The present invention is a completely different method for chemically synthesizing aminoacyl-tRNA, which does not require a genetic engineering technique, is simple, and can aminoacylate any unnatural amino acid. Furthermore, it is an ob...
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JP2005537325A |
The present invention relates generally to a method of modulating T cell functional activity by utilising beta-amino acid substituted peptides and to agents useful for the same. More particularly, the present invention relates to a metho...
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JP3716293B2 |
To efficiently extract the subject high molecular weight compound useful for fiber processing agents, feeds, cosmetics, etc., in high yield by circulating high temperature water to cut cocoon obtained by cutting one end part of cocoon, r...
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JP2005533753A |
The present invention relates to compositions and methods for suppressing an immune response, e.g., by inhibiting class II MHC-mediated activation of T cells. The subject compounds and methods may be used to treat or prevent disorders su...
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JP2005314265A |
To provide an age resistor containing a collagen peptide having high cell-bonding effects.The collagen peptide having ≥500 and ≤2,000 average molecular weight exhibits the high bonding effects to a cell such as a fibroblast and an ep...
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JP2005314346A |
To provide a method for screening a compound capable of accelerating the formation of a nano structural material of a metal in an aqueous solution, a method for producing metal fine particles by using the screened compound and a compound...
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JP2005314410A |
To provide a substance having an effect of inhibiting a cladsporium carpophilum disease of agricultural products including potatoes that can be safely and efficiently used in actual cultivation in fields.An acyl peptide compound componen...
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JP2005518182A |
The present invention relates generally to peptides, polypeptides or proteins having one or more amino acids or one or more amino acid sequences which exhibit color-facilitating properties, either on their own or following interaction wi...
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JP3660270B2 |
To provide an isolated immunoglobulin characterized in that it comprises two heavy(H) polypeptide chains sufficient for the formation of one complete antigen binding site or several antigen binding sites, and is further devoid of light(L...
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JP2005118044A |
To provide a new sequence of hepatitis C virus genotype and its use as prophylactic, therapeutic and diagnostic agents.The invention relates to HCV polynucleic acid or a complement thereof having a nucleotide sequence which is unique to ...
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JP2005512980A |
Compounds of formula SEQ ID NO:2 and SEQ ID NO:3, which are useful for treating conditions that arise from or are exacerbated by angiogenesis, are described. Also disclosed are pharmaceutical compositions comprising these compounds, meth...
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JP2005508899A |
The present invention concerns an NCAM (neural cell adhesion molecule) binding peptide capable of stimulating NCAM signalling and/or interfering with cell adhesion. The compound may be used for the treatment of diseases or conditions of ...
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JP2005060550A |
To provide a film-forming composition which contains a polypeptide having collagen-like characteristics and also which has such a high safety that there may be none of dangers to be infected with a pathogen or a pathogenic factor.THe fil...
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JP3619827B2 |
We have discovered epitopes of the HCV viral proteins which are immunoreactive with immune serum. The epitopes are useful in immunodiagnostic assays and as immunogens.
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JP3578799B2 |
The present invention relates to a polypeptide of the bacterium Streptococcus suis with a molecular weight of about 54 kD, capable of inducing neutralising antibodies against Streptococcus suis. The invention also relates to a vaccine ag...
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JP3568978B2 |
Novel antibiotic stalobacins H and I having physico-chemical properties as shown in Table 1 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.
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JP3560626B2 |
PURPOSE: To provide a process for the recovery of even an extremely small amount of valuable substance in a high efficiency at a low cost without lowering the activity and widely utilizable for the recovery of various natural and synthet...
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JP2004520850A |
Peptide coupled with at least one fluorogenic or colorogenic reporter molecule, characterized in that it contains at least one amino acid sequence able to be cleaved by calpain 3. Method for detecting, in vitro, the activity of calpain 3...
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JP2004175699A |
To provide a hair treatment preparation improving hair setting ability and hair combability through making the hair smooth, imparting the hair with good gloss and moist feeling and finishing the hair to pliant touch.This hair treatment p...
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JP2004512255A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2004107275A |
To provide an antimicrobial peptide causing no decline in antimicrobial activity even if adsorbed to anionic matter or the like such as a cationic antimicrobial peptide, and to provide antimicrobial agents, sterilizers and preservatives ...
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JP3516681B2 |
We have discovered epitopes of the HCV viral proteins which are immunoreactive with immune serum. The epitopes are useful in immunodiagnostic assays and as immunogens.
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