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Matches 1 - 50 out of 17,770

Document Document Title
WO/2021/068080A1
Described herein is an immunogenic fusion protein comprising: an immunogenic peptide or an immunogenic variant thereof, the immunogenic peptide comprising the following motifs: - KQPAa; QPAKa; PAKQa; or AKQPa; - NPDPb; PNPDb; DPNPb; or P...  
WO/2021/070920A1
A cyclic peptide that has a cyclic structure consisting of 4-30 amino acids or derivative(s) thereof, or a pharmaceutically acceptable salt thereof. In the cyclic structure, the cyclic peptide contains at least carboranylalanine(Cba) and...  
WO/2021/070083A1
Compositions for making native-like marine structures are provided. The compositions include materials, typically a limestone and/or ceramic composite, for 3D printing of marine structures. Environmentally-friendly 3D printing and coatin...  
WO/2021/072212A1
In some embodiments, the present disclosure provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt thereof. In some embodiments, the present disclosure provides a compound of Formula (II) as describ...  
WO/2021/070696A1
The present invention provides a cyclic peptide that has, in a ring, an amino acid sequence represented by formula (I): X1-His-Pro-X4-Leu-X6-X7-X8-Ser-X10-His-Phe (where X1, X4, X6, X7, X8, and X10 each independently represent an arbitra...  
WO/2021/064593A1
The present invention relates to novel linear ultrashort lipopeptides, pharmaceutical and cosmetic compositions comprising lipopeptides, and lipopeptides for use as drugs in treatment of bacterial infections.  
WO/2021/064361A1
The invention relates to the detection of EGYR peptide in a biological sample as a measure of the presence and/or amount of LARP1 protein in the sample. Suitably, the invention relates to methods for quantitative measurement of LARP1 and...  
WO/2021/067460A1
The disclosure provides cryptophycin intermediates, cryptophycin analogs, and cryptophycin chimeric molecules useful in treating cancer, as well as methods of producing these compounds and methods of treating cancer.  
WO/2021/064191A1
In vitro method for detecting, localising and/or quantifying multidrug resistant (MDR) proteins associated with cells, in a sample containing prokaryotic or eukaryotic cells expressing or capable of expressing MDR proteins. The method co...  
WO/2021/066649A1
The invention provides method of treatment comprising administering an AQGV peptide, or a functional analogue thereof, to a human subject, the human subject optionally having impaired kidney function, wherein the treatment of administeri...  
WO/2021/059267A1
Pharmaceutical compositions comprising specific tetrapeptides, for use in treating, preventing, minimizing, diminishing or reversing degenerative, age-related and trauma- induced disorders, particularly of the eye, are provided.  
WO/2021/059755A1
The present invention addresses the problem of providing a technique that enables sympathetic nerve activation. A composition for sympathetic nerve activation, said composition containing one or more peptides selected from the group cons...  
WO/2021/060441A1
To provide a high-molecular-weight degradable multi-arm polyethylene glycol derivative that does not cause cell vacuoles. This degradable polyethylene glycol derivative is represented by formula (1). (In the formula, n1 and n2 are each i...  
WO/2021/059266A1
Compositions comprising specific tetrapeptides, for use in treating, preventing, minimizing, diminishing or reversing various signs of aging of the skin are provided. The compositions are useful in improving the firmness or elasticity of...  
WO/2021/059840A1
[Problem] To provide: a dipeptide having an inhibitory activity against an angiotensin converting enzyme; and others. [Solution] The purpose can be achieved by an angiotensin converting enzyme (ACE) inhibitor comprising at least one dipe...  
WO/2021/060443A1
Provided is a high-molecular-weight branched, degradable polyethylene glycol derivative which does not cause cell vacuoles. The branched, degradable polyethylene glycol derivative represented by formula (1) includes an oligopeptide that ...  
WO/2021/060439A1
The present invention addresses the problem of providing: a heterobifunctional monodispersed polyethylene glycol having two adjacent monodispersed polyethylene glycol side chains which can sustainedly release a drug upon the decompositio...  
WO/2021/054927A2
The present invention describes compositions containing cholesterol-linker-glutathione conjugates for targeting the brain by overcoming barrier entry to the CNS through the blood brain barrier (BBB), including micelle and liposome forms ...  
WO/2021/047558A1
Provided is a flanking sequence pair for SspDnaE, SspDnaB, MxeGyrA, MjaTFIIB, PhoVMA, TvoVMA, Gp41-1, Gp41-8, IMPDH-1, or PhoRadA split intein. The flanking sequence pair comprises: flanking sequence a and flanking sequence b, the flanki...  
WO/2021/047524A1
The present invention belongs to the field of medical technology and relates to a class of functional small molecules targeting proteolysis pathways, a preparation and an application thereof. Specifically, the present invention relates t...  
WO/2021/047470A1
A method for preparing a peptide amide compound represented by formula (N) and an intermediate thereof; the method has mild reaction conditions, simple operations, high reaction yield, high product purity and convenient post-treatment, a...  
WO/2021/045166A1
The present disclosure relates to a composition: that contains a polymer compound; that is capable of promoting cell proliferation; that can be used for wound coverings; and that is for culturing or storing cells and tissues. The composi...  
WO/2020/249605A3
A number of anti-angiogenic strategies connected with the VEGF signalling pathway are used in current clinical treatment or trial phase, but they either cause adverse effects or are not specific. Various strategies were aimed at identify...  
WO/2020/218727A9
The present invention relates to peptides isolated from a protein hydrolysate of Tenebrio molitor mealworm and a composition comprising same as an active ingredient for prevention or treatment of liver injury. According to the present in...  
WO/2021/030743A2
The present invention provides a compound of formula (I): A-B-C (I), wherein A is a hydrophobic moiety; B is a peptide, wherein the peptide forms a beta-sheet; and C is a hydrophilic targeting ligand, wherein the hydrophilic targeting li...  
WO/2021/020421A1
A cell death inhibitor that has as an effective component thereof ascorbic acid, a derivative thereof, a salt thereof, or a solvate thereof and inhibits cell death induced by transient protein expression in plants. The cell death inhibit...  
WO/2021/020585A1
To provide a novel heterocyclic compound which has an effect of inducing the degradation of IRAK-M protein and which is expected to be useful for preventing or treating cancer, fibrosis, infectious diseases, etc., and a medicine comprisi...  
WO/2021/018862A1
The present invention relates to SS-31 or composition comprising SS-31 for use in the treatment and/or prevention of aneurysm.  
WO/2021/013086A1
A compound as represented by general formula (I) or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutically acceptable salt, or a co-crystal thereof, a composition thereof, a preparation method therefor, and an application...  
WO/2021/014229A1
The present invention relates to a compound of formula (I) or an enantiomer, to a pharmaceutically acceptable salt or solvate of this compound, or to a mixture thereof, wherein the core A, the substituents Z, Y and R1i are as defined in ...  
WO/2021/013085A1
A compound represented by general formula (I) or stereoisomers thereof, a preparation method therefor, and use thereof in medicine, general formula (I) being shown below, and the definition of each substituent being consistent with that ...  
WO/2021/015041A1
A retardant for the progression of aging that comprises a peptide Gly-Pro and/or a peptide Glu-Hyp-Gly, a salt thereof or a chemically modified product of the same.  
WO/2021/013684A1
The invention relates to detergents or cleaning agents comprising (i) at least one protease which comprises an amino acid sequence which has at least 70% sequence identity to the amino acid sequence given in SEQ ID No. 1 over its entire ...  
WO/2021/013155A1
Disclosed are a new glycosyl donor, a preparation method therefor, and an application thereof. Specifically, a glycosyl donor represented by formula (I), a preparation method therefor, and a use of the glycosyl donor represented by formu...  
WO/2021/016182A1
Ligand-drug conjugates for targeted melanoma therapies are disclosed herein. A ligand is conjugated to a cytotoxic cancer drug through a cleavage linker. The ligand can bind to an overexpressed receptor on a cancer cell, resulting in sel...  
WO/2021/010482A1
The present invention provides a peptide that disrupts the self-aggregation of an AtaA polypeptide or separates a bond between the AtaA polypeptide and another subject. A peptide found by the present inventors has the properties of disru...  
WO/2020/247933A3
Provide for herein are cyclic or linear peptides that bind HIV-1 capsid protein and inhibit HIV-1 capsid from assembling and/or disassembling. Further provided are methods of making said peptides and pharmaceutical compositions and metho...  
WO/2021/004463A1
A method for preparing an antioxidative peptide from a peanut meal by employing a high pressure-assisted enzymatic hydrolysis method, comprising the extraction of heat denatured protein in the peanut meal, high-pressure preprocessing, en...  
WO/2021/003399A1
Provided herein are antibodies that specifically bind to human tissue factor (TF), anti-TF antibody-drug conjugates (ADCs), and compositions comprising the antibodies or ADCs. Also provided herein are methods of making and using the anti...  
WO/2021/001244A1
The present invention relates to a compound for stabilizing enzymes, the use of said compound for stabilizing an enzyme, a composition comprising said compound, a method of preparing the composition comprising said compound, a detergent ...  
WO/2021/003171A2
The present disclosure is directed to peptoids and peptoid multimers that inhibit IL-15 and their use in treating autoimmune/infiammatory diseases.  
WO/2021/002408A1
The present invention provides a peptide having a fluoroalkyl group as a side chain. The present invention is a method for manufacturing a fluoroalkyl-group-containing peptide in which a compound represented by general formula (6-2) or (...  
WO/2020/264187A1
The present invention generally relates to compounds that are useful for inhibiting one or more trypsin-like S1 serine proteases, HGFA, matriptase, hepsin, KLK5 and/or TMPRSS2 as well as cysteine proteases including trypsin-like cysteine...  
WO/2020/259726A1
The present invention relates to cyclen based compounds of general formula (I), wherein X is nitrogen and Y, Z are –CH-, or X, Z are –CH- and Y is nitrogen, or X, Y are –CH- and Z is nitrogen; R1 is independently selected from H; C...  
WO/2020/260309A1
The invention provides a compound characterized by formula (1): X1-Thr-Thr-Ala-Arg-X2, wherein cleavage of the compound into a fragment 1 comprising X1 and a fragment 2 comprising X2 generates a detectable signal. The invention further p...  
WO/2020/218727A3
The present invention relates to peptides isolated from a protein hydrolysate of Tenebrio molitor mealworm and a composition comprising same as an active ingredient for prevention or treatment of liver injury. According to the present in...  
WO/2020/257745A1
Compounds, compositions, and methods are provided that are useful in treating brain diseases by effecting delivery across the blood brain barrier of molecules that otherwise do not (or insignificantly) pass across the blood brain barrier...  
WO/2020/249745A1
The present invention relates to cationic micelles, and in particular the compounds capable of forming such cationic micelles for use in cell tracking.  
WO/2020/244224A1
Disclosed are a tripeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor and an application thereof. The structure of the tripeptide ethylene oxide derivative is as represented by...  
WO/2020/245772A1
The present invention relates to bioactive peptides and to the cosmeceutical compositions comprising them, useful for the prevention and treatment of the signs of skin aging, such as wrinkles, fine lines and loss of firmness and elastici...  

Matches 1 - 50 out of 17,770