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Matches 151 - 200 out of 1,219

Document Document Title
WO/2010/049611A1
The invention relates to a new type of polysaccharide-block-polypeptide diblock copolymer which is bioresorbable or biodegradable and biocompatible, to a method for preparing same, to the micellar vesicles constituted of this copolymer, ...  
WO/2010/006343A2
Glycopeptide conjugates, and methods of making and using such conjugates are disclosed. Certain glycopeptide conjugates comprise tumor associated carbohydrate antigens and peptide epitopes. Certain glycopeptide conjugates comprise cyclic...  
WO/2009/120022A2
The present invention relates to an immunopeptide and to a composition for the prophylaxis or treatment of HPV-related medical conditions comprising the same. More specifically, it relates to an E7 immunopeptide derived from the E7 prote...  
WO/2009/115782A2
The invention provides a compound (which can act as an adjuvant) of Formula I or Formula (Il), wherein R1 R4 R5 R6 and R7 are each independently selected from hydrogen, acetyl, hydrocarbyl, a lipid moiety and a lipid acyl moiety; R2 is a...  
WO/2009/108807A1
In one embodiment, the invention provides glycopeptides (or carbohydrate-peptide conjugates) comprising TACAs that direct against (e.g., bind specifically to) cytotoxic T lymphocytes (CTLs) or helper T cells for, e.g., CTL- or T-helper-b...  
WO/2009/088949A1
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-...  
WO/2009/081958A1
Disclosed is a novel glycopeptide antibiotic derivative. The glycopeptide antibiotic derivative is characterized by having a sugar residue (I) represented by formula (I) [wherein n represents an integer of 1 to 5; Sug's independently rep...  
WO/2009/046618A1
A deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for...  
WO/2009/039185A1
This invention provides method of making and using of a porous 3 dimensional cyclic RGD peptide-modified alginate scaffold that can be loaded with different cell types and/or growth factors for implantation at sites of tissue damage to p...  
WO/2009/037592A2
Aminoglycoside-amino acid and -peptide conjugates comprising a triazolyl linker are provided along with efficient methods of their preparation. The aminoglycoside may be an aminoglycoside antibiotic. Conjugates comprising an aminoglycosi...  
WO/2009/017154A1
It is intended to provide a method for producing a peptide characterized by, in a peptide containing an amino acid residue having an -SH group, converting the -SH group into an -OH group, and including the following steps (a) to (c): (a)...  
WO/2009/006620A1
Provided are methods of producing, and compositions comprising, isolated alpha (2→8) or (2→9) oligosialic acid derivatives bearing a non-reducing end enriched for one or more de-N-acetyl residues and resistant to degradation by exone...  
WO/2008/140973A1
Semi- synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described hereins are made by subjecting the a glycopeptide (Compound A, Compound B, COMPOUND H or Compound C) in ...  
WO/2008/108505A1
Disclosed is a peptide comprising amino acid sequences RI, FI and RIGC and is composed of 25 or less amino acid residues, which can transport a functional molecule into the inside of a cell as well as into the inside of a nucleus more ef...  
WO/2008/100966A1
Compositions that include peptides derived from glial-derived neurotrophic factor (GDNF) (e.g., substantially pure polypeptides comprising a fragment of a GDNF precursor protein) and biologically active variants thereof are provided. The...  
WO/2008/093165A2
Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA compri...  
WO2008076483A9
The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomy...  
WO/2008/077241A1
The present invention is directed to antimicrobial compounds which have an affinity for binding bones. More particularly, the invention is directed to phosphonated derivatives of glycopeptide or lipoglycopeptide antibiotics. These compou...  
WO/2008/055059A2
Novel bifunctional peptides useful in the treatment and/or diagnosis of EAE or MS. The peptides have a first peptide portion derived from an epitope of myelin proteolipid protein, myelin oligodendrocyte glycoprotein, or oligodendrocyte-s...  
WO/2008/042421A2
Peptides derived from the C2 regions of εPKC and methods of use, thereof, are described. These peptides modulate the activity of εPKC in an animal model of acute ischemic heart disease.  
WO/2008/034575A1
The iminosugar conjugates having the structural formula (I) with integer n≥0; R1, R2, being chosen from H, OH, NHAc, OGlycosyl, O(CH2)mCH3, or O(CF2)mCF3; R3, R4, R5, and R6 being chosen from H, OH, OGlycosyl, O(CH2)mCH3, or O(CF2)mCF3...  
WO/2008/028050A2
The present invention relates to methods of use of glycosyltransferases and related novel compounds. The invention exploits the reversibility of glycosyltransferases to generate new sugars, unnatural biomolecules and numerous one-pot rea...  
WO/2008/019051A2
Devices, bandages, kits and methods are described that can control or regulate the mechanical environment of a wound to ameliorate scar and/or keloid formation. The mechanical environment of a wound includes stress, strain, and any combi...  
WO/2008/011168A2
A compositions of matter and pharmaceutical compositions are disclosed, which in various embodiments, comprise biologically active glycosylated peptides that can be used therapeutically or prophylactically against diseases or conditions ...  
WO/2007/138999A1
It is intended to provide a novel glycopeptide antibiotic derivative. A compound represented by the formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. In the formula (I), RA represents -X1-Ar1-X2-Y-X3-Ar2 (X1, ...  
WO/2007/112348A2
A prodrug composition is provided which includes a pharmaceutical species and an amino acid having a covalent bond to the pharmaceutical species. A particular pharmaceutical species is adenosine arabinoside, also known as Ara A and by th...  
WO/2007/111952A2
A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coupled with a C-terminal peptide portion bearing a carbohydrate moiety...  
WO/2007/096517A1
The present invention relates to a solid support bound to at least one molecular frame which makes it possible to bind, in a multivalent manner, at least one recognition motif or which presents at least one recognition motif in a multiva...  
WO/2007/068644A1
The present invention concerns a process for the purification of macrolide antibiotics. More specifically it concerns a process for the purification of macrolide antibiotics that result in a white powder. The powder remains white also af...  
WO/2007/064759A2
The present invention relates to new compositions and methods useful for preventing, treating and diagnosing metastatic and/or invasive cancer and undesirable angiogenesis. For example, the invention relates to inhibitors of proteases th...  
WO/2007/054717A2
The present invention relates to the use of STAUROSPORINES DERIVATIVES for the preparation of a drug for the treatment of diseases involving SPTBN1-FLT3 translocation- modulated signalling pathways and / or SPTBN 1-FLT3 translocation gen...  
WO/2007/010995A1
A convenient method of stabilizing peptides contained in a biosample, and a relevant stabilizing reagent; a convenient method of preserving a biosample containing peptides, and a relevant preserving reagent; and an accurate method of mea...  
WO/2007/001335A2
Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial ag...  
WO2006059227B1
The invention concerns a gem-difluorinated C-glycopeptide compound of formula (I) in which N is an integer between 1 and 5, R4= H, AA1, AA1-AA2 and R5= OH, AA1, AA1.AA2, with AA1, and AA2 are independents and representing amino acids wit...  
WO/2006/092313A1
The present invention relates to lipopeptides having pharmaceutical activity, to methods of their isolation and production, to pharmaceutical composition and uses thereof and to cyano-bacteria from which the compounds may be isolated.  
WO/2006/061101A2
Disclosed is a peptide comprising the sequence: H2N-Gly-Phe-D-Thr-Gly-Phe-Leu-Ser-CONH2, wherein the serine residue may be functionalised with sugar residues; other aminoacids can replace the first two aminoacids of the N-terminal portio...  
WO/2006/061166A1
The new pure vancomycin hydrochloride substantially free of impurities known in commercially available products is described. The term 'substantially free of impurities' designates a purity of vancomycin hydrochloride between about 97% a...  
WO/2006/052129A2
The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable o...  
WO/2006/045627A1
A novel and improved method for purification of glycopeptides, especially glycopeptide antibiotics. The method comprises contacting a solution of the glycopeptide to an ion exchange chromatography material. The product of this method has...  
WO/2006/017180A2
This invention provides compounds represented by the formula: (A-X---)n wherein each A- is independently a carbohydrate represented by the general structure: wherein each of B, C, D, E, F, G, H, I, and J independently represents a sugar ...  
WO/2006/004238A1
Provided is a method of purifying a vancomycin from a fermentation broth of a microorganism containing vancomycin, including passing the fermentation broth of a microorganism containing vancomycin through a strong acid cation exchange re...  
WO/2005/118625A1
The invention concerns staff a analogues of glycoamino acids and glycopeptides in which the non-sugar acetal heteroatom is replaced by a triazole moiety e.g. compounds of formula (I) or (I') wherein A represents a carbohydrate which is c...  
WO/2005/116059A1
Disclosed is a method of producing highly pure teicoplanin. The method includes a roughly purification step of separating teicoplanin from a porous adsorption resin under a selective elution condition after a culture broth, obtained by c...  
WO/2005/108417A1
A novel compound useful as a primer for the production of a sugar peptide; and a process for producing a sugar peptide with the primer. The compound is (1) a compound represented by the formula X-C(=O)-A1-A2 (I) (wherein X represents hyd...  
WO/2005/097158A1
Glycopeptides which are amphipathic and capable of crossing the blood-brain-barrier are provided. The glycopeptides are useful for treating a variety of neurological an behavioral disorders.  
WO/2005/095331A1
An agent for binding a sugar chain to a peptide which comprises a compound represented by the general formula (I): X-Y-Z (I) wherein X is H2Z- or HS-; Y is -A1-, -A1-O-A2-, -(CH2CH2O)n-A1-, -(CH2CH2O)n-A1-O-A2-, -A1-NH-C(=O)-A2-, -A1-C(=...  
WO/2005/090382A1
The present invention relates compounds of the formula (A) oligosaccharide-spacer-GpIIb/IIIa antagonist (A), wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising four to twenty five monosaccharide units,...  
WO/2005/085294A1
A hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases. The hyaluronic acid/methotrexate compound useful as a therapeutic agent for joint diseases comprises hyaluronic acid and methotrexate bonded to a c...  
WO/2005/079747A1
An pharmaceutical preparation in the form of an aqueous solution comprising: (a) a nonsteroidal anti-inflammatory drug (NSAID) also having analgesic activity; (b) a biologically compatible buffering organic amine provided with a free or ...  
WO/2005/070138A2
The present invention provides polypeptides that include an O-linked glycosylation site that is not present in the wild-type peptide. The polypeptides of the invention include glycoconjugates in which a species such as a water-soluble po...  

Matches 151 - 200 out of 1,219