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WO/2005/063797A1 |
The present invention provides novel nonnatural C-linked carbo-β-peptides with robust secondary structures, which comprises the synthesis of a new class of β-peptides called C-linked carbo-β-peptides, most of which are favorably dispo...
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WO/2005/056572A2 |
The present invention provides novel clustered multi-antigenic; constructs having the structure (I) and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, prefe...
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WO/2005/051982A1 |
It is intended to provide temperature-responsive amphiphilic glycopeptides and temperature-responsive micelles. Namely, a glycopeptide which would not occur in nature and is represented by the following general formula (1) and a temperat...
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WO/2005/044841A1 |
The present invention provides a method for preparing polyfunctionalized peptides and/or proteins at non-adjacent designated sites via native chemical ligation. In certain embodiments, the inventive method is a method for preparing a pol...
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WO/2005/044197A2 |
The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
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WO/2005/042568A2 |
Disclosed are hydrochloride salts of telavancin having a chloride ion content of from about 2.4 wt. % to about 4.8 wt. %. The disclosed salts have improved stability during storage at ambient temperatures compared to other hydrochloride ...
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WO/2005/035588A1 |
Provided are synthetic polysaccharide antigens (SPAs) with anti-inflammatory or inflammatory immunomodulatory properties, depending on their structure. Also provided are compositions comprising these SPAs, and methods of using these SPAs...
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WO/2005/034856A2 |
The invention provides a prodrug platform technology for improving the therapeutic value of a variety of parent drug compounds by altering and improving drug characteristics such as aqueous solubility, hydrolytic stability, therapeutic i...
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WO/2005/023871A1 |
The invention relates to an agent for selective suppression of disease associated B-lymphocytes, more precisely of disease-associated DNA-specific B-cells in systemiclupus erythematosus. The agent is a bispecific chimeric monoclonal anti...
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WO/2005/016248A2 |
A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the com...
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WO/2005/016851A1 |
The invention relates to novel molecules and libraries thereof as well as methods for their production. Methods of producing the novel molecules include a. cleaving one or more of starting molecules into molecular subunits ; and b. assem...
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WO/2005/005436A2 |
This invention provides cross-linked glycopeptide - cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds...
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WO/2005/000873A1 |
A method for the preparation of a glycosylated amino acid, protein or peptide, the method comprising reacting an unprotected carbohydrate compound containing a carbon-carbon double bond with an amino acid, a protein or a peptide containi...
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WO/2004/113350A1 |
This invention provides cross-linked glycopeptide - cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds...
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WO/2004/111192A2 |
The present invention relates to new agents and methods useful for preventing, treating and diagnosing diseases such as cancer. For example, the invention relates to prodrug agents useful for targeting and delivering cytotoxic drugs to c...
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WO/2004/099231A2 |
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.
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WO/2004/099135A2 |
The present invention provides new prodrugs which are conjugates of a therapeutic compound and a peptide wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptida...
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WO/2004/098644A1 |
The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjug...
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WO/2004/096836A1 |
A glycopeptide or peptide having taste improving activity, especially having rich taste imparting activity. In particular, such a glycopeptide or peptide per se; a method of imparting rich taste to food or seasonings with the use of the ...
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WO/2004/094590A2 |
A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The e...
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WO/2004/091552A2 |
The present invention includes apoptosis modulating glucosamine-muramyl-peptides, obtained by specific endopeptidase digestion of gram positive bacteria, methods of preparation of thereof and medical food compositions for management and ...
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WO/2004/090154A2 |
The present invention provides tagged acyl phosphate probes ('TAPPs'), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, am...
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WO/2004/087730A2 |
Described are aminoacyl tRNA analogues which comprise a tRNA, and an amino acid which acts as an acceptor and donor substrate for ribosome-directed translation, thus, incorporating unusual monomers into non-standard polymers by the actio...
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WO/2004/086039A2 |
A method for modulating Nod1 activity wherein said method comprises the steps of providing cells expressing a functional Nod1; and bringing said cells into contact with a molecule related to compositions comprising a molecule related to ...
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WO/2004/083807A2 |
Methods to evaluate and rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a f...
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WO/2004/078781A1 |
The invention relates to low-molecular doxorubicin peptide derivatives containing MMP-2 or MMP-9 divisible peptide sequences and a protein-binding group.
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WO/2004/075843A2 |
It is taught here that enkephalin peptides which are glycosylated with a disaccharide will be transported across the blood brain barrier and deliver analgesic effects superior to morphine when introduced into the bloodstream. Glycosylate...
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WO/2004/076476A1 |
A novel substance usable as a proteoglycan initiator; and a method of efficiently synthesizing such a substance usable as a proteoglycan initiator. In particular, a glycopeptide or product of modification thereof, the glycopeptide having...
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WO/2004/069873A2 |
The present invention is directed to ligand/receptor and antigen/antibody specificity exchangers comprising a saccharide or glycoconjugate. Methods of making these specificity exchangers and methods of using said specificity exchangers t...
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WO/2004/064784A2 |
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.
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WO/2004/044224A2 |
Methods of preparing branched polymer vancomycin conjugates are disclosed. In preferred aspects, the branched polymers contain several equivalents of a vancomycin selectively attached to the sugar amino group of the vancomycin. Multi-loa...
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WO/2004/044222A2 |
Methods of preparing vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are preferably releasable, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related ...
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WO2004016274B1 |
The present invention relates to novel amphipathic peptide-conjugated oligomeric compounds and to methods of making and using such compounds. The invention further relates to methods of enhancing the cellular uptake of oligomeric compoun...
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WO/2004/044223A2 |
Vancomycin-polymer conjugates are disclosed. In preferred aspects, polymer residues which are hydrolysis resistant in vitro, are selectively attached to the sugar amino and/or N-methyl amino groups of vancomycin and related compounds. Va...
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WO/2004/041203A2 |
The present invention provides gemcitabine prodrugs, methods of making gemcitabine prodrugs, pharmaceutical compositions of gemcitabine prodrugs and methods of using gemcitabine prodrugs and pharmaceutical compositions thereof to treat o...
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WO/2004/041194A2 |
Compositions for the inhibition of HIV-1 comprising the use of polyamide nucleic acids (PNAs) that bind to either the transactivation response element or primer binding sequence of the HIV virus are taught. The PNAs may be bound to a mem...
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WO2002043771A9 |
A conjugate of formula A-L-P, in which: A represents a glycosylated/galactosylated peptide that binds to a cell-surface receptor, L represents a bifunctional linker, which does not comprise a naturally occurring amino acid and is covalen...
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WO/2004/035605A2 |
Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method...
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WO/2004/026894A2 |
The invention relates to a method for preparing a grafted homodetic cyclopeptde forming a frame defining two surfaces, one surface being known as the upper surface and the other surface being known as the lower surface, both surfaces bei...
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WO/2004/022578A2 |
This invention pertains to the field of PNA dimer and PNA oligomer synthesis.
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WO/2004/019970A2 |
Novel glycopeptide antibiotic derivatives, processes for their preparation, their use as a medicine, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections are provided...
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WO/2004/011479A1 |
The invention herein provides novel viral DNA polymerase compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with viral DNA polymerase...
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WO/2004/011476A1 |
The present invention provides novel glycosides and glycoconjugates, glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis t...
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WO/2004/005330A1 |
A process for producing a peptide having at least one asparagine sugar chain, characterized by esterifying a hydroxy group of a hydroxylated resin with the carboxy group of an amino acid in which the amino nitrogen has been protected by ...
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WO/2004/000802A2 |
Disclosed are scaffolded maleimide clusters, methods of making said clusters and use of said clusters as templates for multivalent peptide assembly. Multiple maleimide functionalities were introduced onto a scaffold molecule by the react...
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WO/2003/099862A1 |
The invention includes a method for harvesting a polypeptide produced by a host cell, wherein the polypeptide has not undergone intra-cellular post-translational modification, such as dehydration of a serine or a threonine, and/or thioet...
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WO/2003/099858A1 |
This invention provides cross-linked glycopeptide - cephalosporin compounds of formula I and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing s...
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WO/2003/086475A1 |
Disclosed are conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof, e.g. for imaging cancer cells and tumors in vivo.
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WO2001079267A9 |
The stereospecific synthesis of a glycopeptide using a triply orthogonal protection scheme is described, in particular, the synthesis of N-acetylglucosaminyl- beta -(1,4)-N-acetylmuramylmonopeptide and derivatives thereof. The glycopepti...
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WO/2003/084983A1 |
A process for producing a peptide or a protein containing an amino acid residue having a modified side chain characterized by comprising chemically producing a peptide fragment containing an amino acid residue having a modified side chai...
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