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WO/2004/005505A1 |
The present invention relates to a simple, efficient, and accelerated method for enzyme-catalyzed in vitro modification and synthesis of nucleic acid using uninterrupted and brief microwave irradiation at a frequency ranging between 2300...
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WO/2004/000415A2 |
The invention features improved methods of and apparatus for generating and administering treatment dosages of morphogens mobilized from extracellular matrices (ECM) for tissue reconstruction applications. In particular, the invention pr...
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WO/2003/104385A1 |
The present invention relates to a device for membrane passage, which comprises at least two magnetic fields generating means, each of which can generate an alternating magnetic field in a spatially limited area located in or in the imme...
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WO/2003/104448A1 |
Electro-poration device for the permeabilization of cells (C) contained in a substrate (12) comprising a signal generator (3) for generating a stimulating signal (S(t)) applied by means of electrodes (6, 7) to the substrate (12) wherein ...
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WO/2003/104262A2 |
The present invention provides peptides which are based on the HIV GP41 protein and have inhibitory activity against the fusion of HIV virus to its target cells. The invention also provides therapeutic methods based on the administration...
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WO/2003/101586A1 |
The present invention relates to apparatus for recovering selected particles having predetermined properties from a number of particles. The apparatus includes a stimulation system, a detection system, a retriever and a control system. I...
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WO/2003/102126A1 |
The present invention relates generally to the field of tissue engineering and more particularly to a method for generating tissue suitable for use in tissue replacement and/or tissue rejuvenation therapy and/or as a source of cell-deriv...
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WO/2003/102125A1 |
The present invention relates to a method and apparatus for fusing first and second cells. In particular, the method includes positioning the first and second cells between two electrodes (35) in a fluid filled container (40) using a pip...
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WO2003078362B1 |
The invention relates to novel methods for affecting, controlling and/or directing various reactions and/or reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern....
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WO2003078361B1 |
This invention relates to novel methods for affecting, controlling and/or directing various reactions and/or reaction pathways or systems by exposing one or more components in a holoreaction system to at least one spectral energy pattern...
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WO/2003/089581A2 |
A method of increasing the growth rate of procaryotic and eucaryotic cells in culture is provided. The method teaches the exposure of the cells in culture to ultrasound of a selected frequency and intensity during incubation to improve c...
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WO/2003/089692A2 |
This invention relates to novel methods for affecting, controlling and/or directing various crystal formation, structure formation or phase formation/phase change reaction pathways or systems by exposing one or more components in a holor...
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WO2003031643A9 |
The invention is based in part on the discovery that the expression of co-stimulatory molecules such as B7.1, B7.2 or CD40 can be regulated using reactive oxygen species (ROS). Thus, the invention relates to methods of regulating co-stim...
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WO/2003/071140A2 |
A method of determining information about cell viability and other characteristics relating to cell membrane permeability is disclosed. The method involves determining the effect of a cell on current flow and relating that effect to a kn...
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WO/2003/070933A2 |
The invention relates to the use of an electrical field applied to a mixture containing a first type of cell (C1), a second type of cell (C2), a bispecific ligand able to bind to C1 and&sol or to C2 and non−covalent complexes formed be...
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WO/2003/068953A1 |
A voltage generator circuit (20) for generating a voltage is provided. A voltage application circuit (30) which is composed of electrodes (11, 12) for generating, on receiving the voltage generated by the voltage generator circuit (20), ...
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WO/2003/066108A1 |
The present invention relates to methods and treatment systems for inactivation of microbes and/or nucleic acids in biological fluids, especially platelet compositions without completely damaging antigens, enzymes and membrane functions....
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WO/2003/063915A1 |
Methods and apparatuses are provided for inactivation of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood pro...
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WO/2003/064590A2 |
Microfluidic systems and methods are disclosed which are adapted to transport and lyse cellular components of a test sample for analysis. The disclosed microfluidic systems and methods (Figure 5A), which employ an electric field to ruptu...
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WO/2003/060114A2 |
The invention relates to a method for disruption of biological cell material for extraction of cellular contents or inclusion of active agents in biological cell by means of continuously alternating electric fields with abrupt field stre...
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WO/2003/055976A2 |
An apparatus (10) for disrupting cells or viruses comprises a container (18) having a chamber (40) for holding the cells or viruses. The chamber is defined by at least one wall (46, 86) having an external surface to which is coupled a tr...
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WO/2003/056321A1 |
An apparatus for stimulating an animal cell and recording its physiological signal and production and use methods thereof are provided. The apparatus can efficiently and conveniently and accurately stimulate an animal cell and record its...
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WO/2003/047684A2 |
The present invention is related to methods in which an electric field pulse is applied to cells and tissue. Several embodiments of the present invention relate to the application of electric field pulses to cells to regulate the physiol...
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WO/2003/048355A1 |
High frequency interfacing to biochemical membranes, such as supported bilayers and cell membranes, is carried out by supporting a biochemical membrane on a support surface while allowing access to the surface of the membrane through an ...
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WO/2003/046171A1 |
Disclosed is a method for sequential delivery of agents to and/or into a cell structure, wherein an electrolyte-filled tube is provided together with a counter electrode, said tube is connected to a voltage or current generator, at least...
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WO/2003/046170A1 |
Disclosed is a method for parallel delivery of agents to and/or into a cell structure, wherein at least two electrolyte-filled tubes are provided together with a counter electrode, the tubes being connected to a voltage or current genera...
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WO/2003/046511A2 |
The present invention relates in general to molecular and cellular biomagnetic assays and, in particular, to molecular and cellular biomagnetic assays conducted on magneto−optical bio−discs. The invention further relates to magnetoâˆ...
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WO/2003/026769A2 |
Methods are disclosed for sterilizing preparations of glycosidases to reduce the level therein of one or more active biological contaminants or pathogens, such as viruses, bacteria (including inter- and intracellular bacteria, such as my...
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WO/2003/027224A1 |
Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the pro...
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WO/2003/025136A2 |
A method is disclosed for increasing the production of an enzyme by a microorganism. The method comprises placing a microorganism that produces an enzyme into a medium that supports growth of the microorganism, and applying an electrical...
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WO/2003/020324A2 |
Methods are disclosed for sterilizing preparations of digestive enzymes to reduce the level of one or more active biological contaminants or pathogens therein, such as viruses, bacteria (including inter- and intracellular bacteria, such ...
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WO/2003/020915A2 |
An object of the invention is to provide a method of treating biological cells prior to subjecting the biological cells to cell fusion pulses which includes the step of treating the biological cells with pre-fusion electric field wavefor...
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WO/2003/018783A1 |
A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the blastocyst stage embryo by laser ablation, ...
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WO/2003/013647A2 |
An object of the invention is to provide a method for delivery of macromolecules into biologicale cel ls in the tissues of a patient and includes the steps of: (a) providing electrodes (16) in an electrode assembly (12), whrein the elect...
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WO/2003/012396A2 |
A process for the preparation of active receptor and receptor complex fractions from cell lines expressing cell surface receptors which comprises applying ultrasonication to provide said expression to the cells in an aqueous (detergent f...
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WO/2003/012029A2 |
A method for enhancement of cell growth, the method including the steps of: (a) providing a system including: (i) an ultrasound transducer; (ii) an interface medium for promoting ultrasound transmission, and (iii) at least a first type o...
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WO/2003/008572A1 |
The present invention relates to methods of creating genetic diversity .The invention also relates to methods of making nucleic acid libraries and their uses to screen for biological activities. The invention can be used to create, impro...
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WO/2003/000838A1 |
A device and a method for cultivation capable of culturing liquid substances such as cells and plasma without variation by making uniform a current density, the device comprising a container (14) of a specified volume having a lower elec...
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WO/2002/092806A1 |
The invention features apparatuses and methods for inactivating viruses, bacteria, and other pathogens in protein-containing fluids. The apparatuses include a radiation transparent housing at least of a portion of which is radiation tran...
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WO2001097868A9 |
The present invention provides a method for inactivating nucleic acid strands using broad-spectrum pulsed light. The nucleic acid strands to be inactivated may be in biologically derived compositions, reagents and devices, waste products...
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WO/2002/075022A1 |
Disclosed are methods using neutral red to mediate the interconversion of chemical and elctrical energy. Electrically reduced neutral red has been found to promote cell growth and formation of reduced products by reversibly increasing th...
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WO/2002/072813A1 |
Methods, systems and apparatus for photo-processing of fluids, particularly complex fluids, such as blood products, pharmaceuticals, injectables and vaccines, are provided. The disclosed methods and systems employ non-laser light source(...
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WO/2002/072631A2 |
Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, inc...
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WO2002000870A9 |
Described is a method for transfecting a cell comprising bringing a complex comprising vector(s) and magnetic particle(s) in contact with a cell by applying a magnetic field and methods of treatment using said method. Furthermore, descri...
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WO/2002/070682A2 |
Compositions comprising one or more pluralities of yeast cells, wherein said pluralities of yeast cells characterized by a substantial increase in their capability to (1) to degrade polymeric compounds such as polysaccharides and plastic...
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WO/2002/064173A1 |
In order to inactivate bacteria and viruses from human or animal blood plasmas, serums or aqueous solutions, said serums are irradiated with low frequency ultrasound under the cover of a protective gas. Carbon dioxide, which is a particu...
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WO/2002/063980A1 |
Methods are provided for readily and efficiently determining resonant frequencies that can be used therapeutically, for stimulation and/or debilitation of specific types of DNA and/or RNA, genes and gene sections, atoms and molecules, an...
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WO/2002/062983A1 |
The present invention relatives to a method for activating ordinary yeast recessive genes by employing simulated life electromagnetic wave information to make the ordinary yeast into specific yeast, wherein the specific proteins (enzymes...
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WO/2002/062985A1 |
The present invention relatives to a method for activating ordinary yeast recessive genes by employing simulated life electromagnetic wave information to make the ordinary yeast into specific yeast, wherein the specific proteins (enzymes...
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WO/2002/062981A1 |
The present invention relatives to a method for activating ordinary yeast recessive genes by employing simulated life electromagnetic wave information to make the ordinary yeast into specific yeast, wherein the specific proteins (enzymes...
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