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Matches 1 - 50 out of 126,294

Document Document Title
WO/2021/092588A1
Disclosed herein are methods for modulating hair growth and increasing hair follicle stem cell activation in an individual in need thereof. This includes administering an agent that modulates a Gas6-Tyro3-Axl-Mertk (TAM) interaction or p...  
WO/2021/090320A1
A method of treating or preventing a sickle cell disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subject a therapeuti...  
WO/2021/092047A1
Provided herein are methods of generating a population of enucleated erythroid cells.  
WO/2021/090031A1
The invention relates to in vitro methods for isolating, or producing selected populations of human epicardial cells derived from human pluripotent stem cells; defined mixtures of said cells, and therapeutic uses thereof. Said population...  
WO/2021/092564A1
Provided herein are methods for generating cultivated autologous limbal epithelial cell grafts for the treatment of various disorders caused by limbal stem cell deficiency. This invention relates to methods and compositions for treating ...  
WO/2021/091823A1
The disclosure provides compounds of Formula 1, and the pharmaceutically acceptable salts thereof. The variables in Formula 1, e.g. X1-X5, A1, A2, and R1-R4 are described herein. Such compounds are useful as prostaglandin transport (PGT)...  
WO/2021/092097A1
Provided are methods for determining or predicting attributes of therapeutic cell compositions in connection with cell therapy. The cells of the therapeutic cell composition express recombinant receptors such as chimeric receptors, e.g. ...  
WO/2021/088214A1
Provided is a short peptide EXP having an amino acid sequence as represented by SEQ ID NO. 1. Also provided are a drug delivery system, a targeted drug delivery system, an enhanced-type drug carrier, an enhanced-type drug during transpor...  
WO/2021/067664A3
Described herein are compositions, kits and methods for shredding the genomes of selected cell types, for example, the genomes of selected cancer cell types.  
WO/2021/092226A1
Described herein, in certain embodiments, are methods of determining an outcome of at least one embryo following transfer of the embryo to a recipient female, where the outcome is based on the expression of at least one gene in an endome...  
WO/2021/092193A1
The present disclosure relates to high-throughput screening methods for identifying one or more chromatography operational parameters (e.g., binding parameters) and/or reagents for purifying EVs (e.g., exosomes) from a sample using chrom...  
WO/2021/090877A1
This brain organoid, which has a phosphorylated 3-repeat tau protein and a phosphorylated 4-repeat tau protein, can be produced by a brain organoid production method including a step 1 for performing floating culture on human pluripotent...  
WO/2021/092252A1
Methods for preparing T cells or NK cells expressing a chimeric antigen receptor (CAR) is described. The methods entail: isolating a population of T cells, generating induced pluripotent stem cells (iPSCs) from the T cells, introducing a...  
WO/2021/087839A1
Provided are a tumor-specific polypeptide sequence and an application thereof. The polypeptide comprises at least any polypeptide in a first peptide group, and can optionally comprise at least any polypeptide in a second peptide group. T...  
WO/2021/092589A1
The disclosed subject matter provides for genetically modified cells, e.g, fungal cells, that autonomously generates and/or secretes one or more therapeutic molecules, e.g, therapeutic peptides, therapeutic proteins or small therapeutic ...  
WO/2021/090925A1
Provided are a polypeptide having excellent 4-aminobenzoic acid hydroxylation activity and a method for using the polypeptide. This polypeptide having 4-aminobenzoic acid hydroxylation activity comprises an amino acid sequence represen...  
WO/2021/090888A1
Provided is a method for producing a target protein using an animal cell as an expression host. A target protein is produced by culturing animal cells having the ability to produce the target protein under conditions of enhanced phosphor...  
WO/2021/091185A1
The present invention relates to a method for producing a paracrine factor, and a composition for cell culture, comprising the paracrine factor. The present invention provides: a method for producing a paracrine factor which is capable o...  
WO/2021/090321A1
A method of treating or preventing a T cell mediated autoimmune disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting immature hematopoietic cells into the subject; and (b) administering to the subje...  
WO/2021/092581A1
Provided herein are genetically engineered mammalian stem and progenitor cells that have increased potential to differentiate into regulatory T cells. Also provided are methods of making and use thereof.  
WO/2021/092358A1
The present inventive concept is related to a modified follicle-stimulating hormone (FSH), in particular, a hypo-glycosylated form of FSH, as well as compositions and formulations including, nucleic acids encoding, cell lines expressing,...  
WO/2021/088777A1
A monocytes derived signaling cells mixture is prepared by culturing buffy coats in a cell culture medium containing platelet-poor-plasma and collecting the cultured buffy coats and the cultured cell culture medium. The monocytes derived...  
WO/2021/092143A1
In various aspects and embodiments the invention provides compositions and methods useful in the treatment of disease. In one aspect the invention provides a composition comprising a polynucleotide comprising one or more of SEQ ID NOS: 1...  
WO/2021/091938A1
The disclosure provides polynucleotides containing outer hair cell-specific promoters, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in outer hair cells. The polynucleotides de...  
WO/2021/088119A1
Provided is a culture medium containing amphiregulin for culturing primary breast epithelial cells and a culture method involving using the medium. In the culture method, primary cells are cultured on a culture vessel coated with an extr...  
WO/2021/091183A1
The present invention relates to a method for preparing a paracrine factor and to a paracrine factor prepared thereby. The objective of the present invention is to provide a method for preparing a paracrine factor that can be performed b...  
WO/2021/092333A1
Provided herein are methods of expanding CD161+ T cells. Also provided are methods and compositions for generating modified CD161+ T cells comprising a chimeric antigen receptor (CAR). In particular aspects, CAR-expressing T cells are pr...  
WO/2021/090333A1
The present disclosure discloses an in-vitro protocol for differentiating human induced pluripotent stem cells (hiPSCs) or human embryonic stem cells (hESC) to give rise to a definitive endoderm, followed by progression into anteriorized...  
WO/2021/091095A1
The present invention relates to an apparatus and method for co-culturing cells. The present invention comprises: a first block including a first port hole and a second port hole, each of which vertically extends therethrough, the first ...  
WO/2021/092245A1
This invention generally relates to compositions comprising thaumatin-like proteins (TLP) and chitinases for use as laboratory reagents or biofungicides. The invention further relates to methods of detecting and inducing pathogen resista...  
WO/2020/180101A3
Provided are an apparatus and method for crystallizing a culture solution using a PCA process. The method for crystallizing a culture solution using a PCA process comprises the steps of: supplying, to a container, a culture solution incl...  
WO/2021/092452A1
Protein-based nanoparticles and methods of forming such protein-based nanoparticles via electrohydrodynamic jetting methods are provided. The nanoparticle may comprise a water- soluble protein having an average molecular weight of ≥ ab...  
WO/2021/091899A1
The present disclosure provides an antibody that binds human Adhesion G Protein-Coupled Receptor B1 (BAI1) protein, compositions comprising the same, and use thereof in methods of detection, methods of diagnosis, and methods of treatment...  
WO/2021/092199A1
Methods for improved handling of isolated canine umbilical cord mesenchymal stromal cells (UC-MSCs), including methods for expansion of canine UC-MSCs, cryopreservation and improved post-thaw viability using adherent plates, as well as s...  
WO/2021/090594A1
A purpose of the present invention is to produce neutrophil-like cells in numbers that can be used in granulocyte transfusion therapy. It became possible to vastly improve proliferation by further forcibly expressing at least one gene be...  
WO/2021/087613A1
A three-dimensional (3D) cell culture system comprising: a solid porous polymeric support, preferably comprising a biocompatible polymer; a first type of cells bound to the solid porous polymeric support; and a biocompatible hydrogel com...  
WO/2021/090945A1
The purpose of the present invention is to provide a cell culture for treating a peripheral arterial disease, a method for manufacturing the cell culture, a method for treating a peripheral arterial disease that uses the cell culture, an...  
WO/2021/092151A1
The present invention relates to bispecific compounds, compositions, and methods for treating diseases or conditions mediated by aberrant histone deacety lase 6 (HDAC6) activity.  
WO/2021/092052A1
Provided herein are methods of generating a population of enucleated erythroid cells.  
WO/2021/088902A1
A composite membrane for ex vivo expansion of circulating tumor cells and a preparation method for the composite membrane, a kit and method for ex vivo expansion of circulating tumor cells, a medication effect test method, and a cryopres...  
WO/2021/089472A1
The invention concerns novel methods and materials for preparing extracellular matrix (ECM) powder pre-gel and gel solutions, for example for use in organoid culture. The ECM gels demonstrate excellent physiological and mechanical proper...  
WO/2021/088847A1
Provided are a method for culturing gynaecological tumour primary cells and a matching reagent, the core of the technique being: using a gentle cell disassociation reagent to treat gynaecological solid tumour tissue to ensure the viabili...  
WO/2021/092173A1
The field is related to plant breeding and methods of identifying and selecting plants with resistance to southern corn rust. Provided are methods to identify novel genes that encode proteins providing plant resistance to southern corn r...  
WO/2021/087840A1
Provided are a tumor immunotherapy polypeptide and an application thereof. The polypeptide comprises at least any polypeptide in a first peptide group, and can optionally comprise at least any polypeptide in a second peptide group; the f...  
WO/2021/067611A3
The present disclosure features methods and compositions for treating Alzheimer's disease. The disclosed methods comprise administering to a subject having or suspected of having Alzheimer's a hematopoietic stem progenitor cell expressin...  
WO/2020/132115A8
This invention provides a variety of novel adeno-associated virus (AAV) vectors for gene therapy applications in the treatment of glycogen storage disease type la (GSD-Ia). Disclosed herein are a number of recombinant nucleic acid molecu...  
WO/2021/090787A1
The purpose of the present invention is to provide a polypeptide which has adhesiveness to endothelial cells but the adhesiveness of which to platelets is suppressed at a low level. A polypeptide that contains an elastin-like block pep...  
WO/2021/092555A2
In certain example embodiments, the invention contemplates a method of screening therapeutic agents for treating cancer comprising co-culturing immune cells and tumor cells isolated from a subject under conditions that allow the immune c...  
WO/2021/088293A1
Provided are a composition for expanding hematopoietic stem cells, an expansion method, pharmaceutical compositions and uses. The composition is composed of JNK-IN-8, rapamycin and Y27632.  
WO/2021/092485A1
The present invention features compositions and methods useful in inhibiting the expression of NFIX within a cell and thereby treating patients suffering from a hemoglobinopathy such as sickle cell disease or β-thalassemia. The present ...  

Matches 1 - 50 out of 126,294