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WO/2022/145588A1 |
The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concent...
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WO/2022/143761A1 |
Provided is a method for introducing a point mutation into a BBD29_04920 gene coding sequence in Corynebacterium or improving the expression thereof. According to the point mutation, the base at position 1560 of the BBD29_04920 gene sequ...
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WO/2022/145586A1 |
The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concent...
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WO/2022/143639A1 |
Disclosed in the present invention are a recombinant strain for producing L-glutamic acid by means of modifying gene BBD29_11265, and a construction method and the use thereof. The recombinant strain is a bacterium that generates L-gluta...
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WO/2022/144195A1 |
The present invention relates to a co-culture system comprising two different strains of the bacterium Cupriavidus necator (Ralstonia eutropha) and its use for production of biomass and value-added compounds.
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WO/2022/143762A1 |
Provided are a recombinant strain of modifying gene BBD29_14900, and a construction method and the use thereof. The specific use thereof is for producing L-glutamic acid. Further provided is a method for introducing point mutation into a...
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WO/2022/139523A1 |
Provided are a novel protein having histidine exporting activity, an L-histidine producing microorganism modified to express the protein, and a L-histidine producing method using the microorganism.
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WO/2022/136300A1 |
The present invention relates to the field of chemical manufacture. In particular, it relates to a method for manufacturing racemic methylglycinediacetic acid (MGDA) comprising the steps of contacting a solution comprising or being enric...
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WO/2022/138969A1 |
The present invention addresses the problem of providing: a mutant L-pipecolic acid hydroxylase for producing cis-5-hydroxy-L-pipecolic acid in a highly productive and highly selective manner by hydrating L-pipecolic acid; and a novel me...
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WO/2022/133917A1 |
A modified Phosphoenolpyruvate carboxylase. Compared to an amino acid sequence of a wild-type Phosphoenolpyruvate carboxylase, amino acids at bit 771 and/or bit 931 and/or bit 943 of an amino acid sequence of the modified Phosphoenolpyru...
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WO/2022/140749A1 |
The present disclosure relates to methods and systems for decarboxylation of amino acids. In particular, such methods and systems can employ an organocatalyst to provide favorable reaction conditions.
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WO/2022/127887A1 |
The present application relates to a method for preparing L-glufosinate using biological multi-enzyme coupling, comprising: in the presence of (R)-transaminase, (S)-transaminase, an amino acceptor, and an amino donor, converting D,L-gluf...
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WO/2022/131323A1 |
One or more embodiments of the present invention provide a microbial strain having an improved ability to produce γ-glutamylcysteine, bis-γ-glutamylcystine, γ-glutamylcystine, reduced glutathione, and/or oxidized glutathione. The pr...
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WO/2022/127886A1 |
The present application relates to a method for preparing L-phosphinothricin by using a biological multienzyme coupling method. The method comprises: a) subjecting D,L-phosphinothricin to a transamination reaction in the presence of (R)-...
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WO/2022/124670A1 |
Provided are a foreign protein-expressing microorganism and an L-amino acid production method using same. The foreign protein-expressing microorganism may have improved L-amino acid excretion and/or production capacity, compared to a wil...
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WO/2022/124639A1 |
Provided are: a saccharomyces cerevisiae mutant strain for producing sphingosine; a saccharomyces cerevisiae mutant strain for producing sphingosine-1-phosphate; methods for producing same; and a method for producing sphingosine or sphin...
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WO/2022/124786A1 |
The present application relates to: a γ-aminobutyrate permease variant that reduces the generation of byproducts upon the production of L-isoleucine; a polynucleotide encoding the variant; a vector carrying the polynucleotide; a microor...
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WO/2022/124511A1 |
The present application relates to a method for producing an L-branched-chain amino acid using a ClpC variant or a Corynebacterium sp. microorganism having weakened mutant ATP-dependent protease activity compared with a non-mutant microo...
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WO/2022/124302A1 |
The present invention addresses the problem of providing: a method for establishing a metabolically engineered microorganism strain capable of high-throughput production of a useful compound; and a metabolically engineered microorganism ...
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WO/2022/124986A1 |
The present invention relates to methods of bioproduction of enantiomerically pure or enantiomerically enriched 2- phenylglycinol or a derivative thereof by multiple enzyme-catalyzed chemical transformations in a one-pot reaction system....
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WO/2022/124671A1 |
Provided are a foreign protein-expressing microorganism and an L-amino acid producing method using same. The foreign protein-expressing microorganism may have improved L-amino acid excretion and/or production capacity, compared to the wi...
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WO/2022/124708A1 |
The present application relates to: a novel branched-chain amino acid aminotransferase mutant for reducing a by-product that is generated when producing L-isoleucine; a polynucleotide for coding the mutant; a vector comprising the polynu...
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WO/2022/108383A1 |
The present application relates to a microorganism having enhanced L-glutamine producing ability, and an L-glutamine producing method using same.
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WO/2022/100568A1 |
Provided is Tricholoma Matsutake, wherein the deposit number thereof is CCTCC No: M 2020587. Also provided are a method and a fermentation broth for the production of ergothioneine by means of Tricholoma Matsutake alone or in combination...
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WO/2022/095591A1 |
A compound enzyme, comprising L-histidine methylase, halogen methyltransferase and trimethylhistidine sulfurylase. L-histidine is catalyzed by L-histidine methylase and halogen methyltransferase to obtain trimethylhistidine, and then is ...
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WO/2022/092018A1 |
Provided is a method of producing an L-amino acid such as L-glutamic acid. According to this method, an L-amino acid is produced by culturing a coryneform bacterium capable of producing the L-amino acid, said coryneform bacterium having ...
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WO/2022/090363A1 |
The present invention relates to a recombinant bacterium genetically modified to produce anthranilic acid and being able to grow in a culture medium lacking tryptophan. It also relates to a method for producing anthranilic acid using sai...
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WO/2022/094445A1 |
The present invention in various aspects and embodiments provides engineered bacterial strains having a modified genome that provides advantages in maintenance and biosynthetic processes when cultured at large scale. The present inventio...
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WO/2022/078127A1 |
Provided are a polypeptide with aspartate kinase activity and the use thereof in the production of an amino acid. Specifically, provided are a novel polypeptide with aspartate kinase activity, a recombinant polypeptide, a polynucleotide,...
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WO/2022/071638A1 |
The present invention relates to a corynebacterium glutamicum variant having enhanced L-citrulline production capacity, and a method for producing L-citrulline using same, the corynebacterium glutamicum variant allowing high-yield produc...
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WO/2022/072490A1 |
The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypepti...
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WO/2022/055203A1 |
Provided are a fatty acid glyceride compound containing sulfate and an amine group, a strain for producing same, a method for producing same, and uses of same. The fatty acid glyceride compound has antibacterial activity, particularly ag...
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WO/2022/055192A1 |
The present application relates to a novel O-phosphoserine export protein and methods for producing O-phosphoserine, cysteine, and a cysteine derivative using the O-phosphoserine export protein.
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WO/2022/054568A1 |
Provided are a polypeptide having excellent 4-aminobenzoic acid hydroxylation activity and a method for using the polypeptide. In the amino acid sequence represented by SEQ ID NO: 2 or an amino acid sequence having at least 90% identity ...
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WO/2022/055094A1 |
The present application pertains to: a recombinant microorganism for producing L-glutamic acid, the recombinant microorganism comprising SbtA protein or a polynucleotide that codes SbtA protein; and an L-glutamic acid production method u...
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WO/2022/049116A1 |
The present invention relates to a microorganism genetically modified for improved production of alanine, wherein the microorganism expresses a heterologous alaD gene coding an alanine dehydrogenase and has reduced Lrp transcription fact...
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WO/2022/050524A1 |
The present invention relates to a Corynebacterium glutamicum variant having an improved L-lysine production ability and a method for producing L-lysine using same. The Corynebacterium glutamicum variant decreases or mitigates the expres...
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WO/2022/050671A1 |
The present application relates to L-valine-producing microorganisms and a L-valine-producing method using the microorganisms. When microorganisms comprising a combination of activity-enhanced or activity-reduced enzymes are cultured, L-...
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WO/2022/050527A1 |
The present invention relates to a Corynebacterium glutamicum variant having an improved L-lysine production ability and a method for producing L-lysine using same. The Corynebacterium glutamicum variant decreases or mitigates the expres...
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WO/2022/040457A1 |
The present disclosure describes the engineering of microbial cells for fermentative production of 4-APEA and related products and provides novel engineered microbial cells and cultures, as well as related 4-APEA production methods.
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WO/2022/037338A1 |
Provided are a polynucleotide having promoter activity and an application of the polynucleotide in producing an amino acid. Also disclosed are a transcription expression cassette, a recombinant expression vector, and a recombinant host c...
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WO/2022/037675A1 |
A preparation method for sulforaphane and a use thereof, which relates to the technical field of biology, the method comprising: taking broccoli seeds or broccoli sprouts, freeze-drying same and then grinding to obtain a first component;...
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WO/2022/036551A1 |
The present invention relates to a Bacillus altitudinis strain and the use of an active substance compound liquid and a microbial inoculant thereof in the prevention and treatment of root-knot nematode diseases. Bacillus altitudinis AMCC...
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WO/2022/039250A1 |
This method of culturing human induced pluripotent stem cells comprises a step for inoculating human induced pluripotent stem cells in a medium at an inoculation density of 1.0×104-1.0×106 cells/cm2 in a culture vessel and two-dimensio...
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WO/2022/032980A1 |
Disclosed are a fresh-cut flower fresh-keeping material and a preparation method therefor. The preparation method for the fresh-cut flower fresh-keeping material comprises: reacting polyglutamic acid and a cross-linking agent in an aqueo...
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WO/2022/035011A1 |
The present invention relates to a microorganism for producing putrescine and a process for producing putrescine by using same.
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WO/2021/184883A9 |
Provided is a method for preparing L-glufosinate-ammonium by deracemization using a bio-enzyme, a mutant of glufosinate-ammonium dehydrogenase, and an application thereof. The method for preparing L-glufosinate-ammonium by deracemization...
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WO/2022/027924A1 |
Corynebacterium glutamicum YP97158 is used as a starting bacterium, and a site-specific mutagenesis and/or enhanced expression are introduced into the NCgl1089 gene coding region, the NCgl0761 gene coding region, and/or the ptsS gene cod...
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WO/2022/018352A1 |
The present invention relates to a method for synthesising functionalised mercaptans, essentially in the absence of oxygen, as well as a composition particularly for implementing said method. The functionalised mercaptans have the follow...
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WO/2022/017221A1 |
Provided are a mutant of a Corynebacterium glutamicum glutamate dehydrogenase gene promoter and an application thereof. The mutant has improved promoter activity compared to a wild-type promoter. Hence, same can be used to enhance the ex...
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