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WO/2019/147865A1 |
Methods for catalyzing C-H insertion reactions using heme enzymes are described. The present disclosure provides a method for producing a C-H insertion product comprising providing an substrate having an sp3-hybridized C-H bond, a carben...
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WO/2019/140682A1 |
Provided are a ketoreductase mutant and an application thereof. The amino acid sequence of the ketoreductase mutant is an amino acid sequence obtained by mutating the amino acid sequence shown in SEQ ID NO: 1, and the mutation comprises ...
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WO/2018/027324A9 |
This disclosure relates to the production of opium poppy plants having high levels of thebaine. More particularly, the disclosure relates to the production of opium poppies having high levels of thebaine by simultaneously reducing the ex...
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WO/2019/128387A1 |
The present invention provides a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and a derivative thereof by using enzymatic resolution, the method comprising the step of: using racemic 1,2,3,4-tetrahydroisoquin...
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WO/2019/130681A1 |
The present invention addresses the problem of providing a method for removing the hydroxyl group at the 8-position of a urolithin to produce a different urolithin. The present invention solves this problem by means of a method for produ...
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WO/2019/128006A1 |
Provided are mold OMK-25 for producing delta-lactone and an application thereof. Mold OMK-25 was deposited in China Center for Type Culture Collection on June 14, 2017 under a collection number of CCTCC M 2017339. Provided is a route for...
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WO/2019/130448A1 |
The present invention addresses the problem of providing a method for removing the hydroxyl group at the 8-position of a urolithin to produce a different urolithin. The present invention solves this problem by means of a method for produ...
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WO/2019/122421A1 |
The present application relates to processes for stereo- and regioselective reduction of cyclohexanones using a ketoreductase enzyme. Compounds prepared according to the disclosed processes are useful in the preparation of compounds for ...
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WO/2019/120132A1 |
A biosynthetic gene cluster-dis427 of Disorazole Z, the nucleotide sequence thereof is as shown in SEQ ID No. 1. An engineered strain DK1622::Km-Ptet-dis427 for heterologous expression of Disorazole Z is constructed by utilizing the gene...
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WO/2019/117612A1 |
The present invention relates to a microorganism variome which is capable of extracellular heme generation, and more specifically, to a metabolically engineered microorganism variome which is capable of extracellular heme generation and ...
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WO/2019/109170A1 |
Disclosed are methods for converting a first morphinan alkaloid compound into a second morphinan alkaloid compound in the presence of a neopinone isomerase enzyme under reaction conditions permitting the conversion of the first alkaloid ...
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WO/2019/013573A9 |
The present invention suggests: a newly shown biosynthesis pathway using the production of homoserine as an intermediate stage for the preparation of 2-hydroxy gamma butyrol acetone (HGBL) and a precursor thereof, 2,4-dihydroxybutanoic a...
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WO/2019/076021A1 |
Provided is a preparation method for hesperetin, comprising: suspending hesperidin or neohesperidin in water, and adding a sodium hydroxide solution until the hesperidin or neohesperidin is completely dissolved to obtain a substrate prep...
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WO/2019/071000A1 |
Disclosed herein are microorganism and methods that can be used for the synthesis of cannabigerolic acid (CBGA) and cannabinoids. The methods disclosed can be used to produce CBGA, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic ac...
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WO/2019/070992A1 |
Metastable state spore incubation mixing systems are described. An example system includes a spore container to store spores, a nutrient container, an arrangement of valves and tubes, a reciprocating pump, a mixing tube, and a holding ta...
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WO/2019/056467A1 |
A Burkholderia strain, specifically Burkholderia glathei ECU 0712, the deposit number thereof being CGMCC No. 14464. The strain or an extract thereof serving as a biocatalyst is applicable in catalyzing the asymmetric oxidation of a thio...
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WO/2019/051046A1 |
[00018] Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids ("BIAs") such as thebaine and morphine and their derivatives. The methods disclosed can be used to produce thebaine, oripavine, codei...
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WO/2019/046954A1 |
A method for decontaminating a biological material contaminated with a trichothecene mycotoxin bearing a 3-hydroxy group, such as deoxynivalenol or vomitoxin, involves oxidation or epimerization of the 3-hydroxy group to convert the myco...
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WO/2019/050990A1 |
This present invention provides for a genetically modified host cell, or a cell-free system reactions, and related methods and materials for the biocatalytic production of an alkyl lactones from a hydroxy fatty acid, or natural alkyl lac...
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WO/2019/046941A1 |
Provided herein are methods and compositions for producing terpenoids in a host cell. In some cases, the terpenoids are cannabinoids.
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WO/2019/046183A1 |
The subject invention provides microbe-based products and efficient methods of producing them. In specific embodiments, methods are provided for symbiotic cultivation of Acinetobacter venetianus RAG1 and Bacillus subtilis B1, as well as ...
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WO/2019/044941A1 |
The purpose of the present invention is to provide a novel compound that has antibacterial activity against Mycobacterium avium and Mycobacterium intracellulare, which are pathogens implicated in MAC infection, and has a backbone structu...
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WO/2019/040585A1 |
Provided herein are improved methods of producing a derivative of PF1022A, for example a compound of Formula I: Formula I wherein R1 and R2 are each independently hydrogen or nitro, and at least one of R1 and R2 is nitro. In some embodim...
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WO/2019/034461A1 |
Described is a process of separating 2,5-diformylfuran from an aqueous mixture comprising dissolved 5-(hydroxymethyl)furfural, dissolved 2,5-diformylfuran and a buffer substance, comprising the step of (a) cooling down the mixture so tha...
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WO/2019/034717A1 |
Described is a process of biocatalytic oxidation of 5-(hydroxymethyl)furfural to 2,5-diformylfuran. The invention furthermore relates to the use of a specific compound as a constituent of a two phase system for biocatalytic oxidation of ...
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WO/2018/229306A9 |
The invention relates to recombinant host cells that expresses one or more genes encoding a cytochrome P450 enzyme capable of N-demethylating and/ O-demethylating reticuline and/or derivatives thereof, and also methods of producing a N-d...
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WO/2019/029408A1 |
Provided are a streptovaricin derivative, a preparation method therefor, and an application thereof, pertaining to the field of bio-pharmaceuticals. The novel streptovaricin derivative 1-4 is obtained by using Streptomyces spectabilis XW...
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WO/2019/028671A1 |
Provides is a method for preparing levetiracetam. The method comprises producing (R/S)-α-ethyl-2-oxo-1-pyrrolidine acetate under the action of an alkaline reagent using 2-bromobutyrate and 2-pyrrolidinone as raw materials, performing re...
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WO/2019/028390A1 |
The present disclosure provides systems and methods for increasing production of an alkaloid product through the epimerization of a (S)-1-benzylisoquinoline alkaloid to a (R)-1-benyzlisoquinoline alkaloid via an engineered epimerase in a...
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WO/2019/019529A1 |
Provided are a Comamonas testosteroni strain and the use of same in the synthesis of 5-hydroxymethyl furoic acid. The strain is Comamonas testosteroni SC1588, deposited at the China Centre for Type Culture Collection, CCTCC for short, on...
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WO/2019/012058A1 |
The invention provides a genetically modified bacterial cell capable of improved iron-sulfur cluster delivery, characterized by a modified gene encoding a mutant Iron Sulfur Cluster Regulator (IscR) as well as one or more transgenes enco...
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WO/2019/011947A1 |
The present invention relates to the field of bio-production of ectoine. There is a need in the art for ectoine production methods allowing its highly efficient synthesis and secretion. The solution proposed in the present invention is t...
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WO/2019/011192A1 |
Provided by the present invention are an aminopeptidase for catalyzed synthesis of dipeptide and a preparation method and application therefor. Said aminopeptidase is an amino acid sequence shown in SEQ ID NO: 2; For the preparation of t...
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WO/2019/014490A1 |
The present disclosure relates to the production of cannabinoids in yeast. In one aspect there is provided a genetically modified yeast comprising: one or more GPP producing genes and optionally, one or more GPP pathway genes; two or mor...
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WO/2019/014395A1 |
The present invention includes systems, methods and compositions for the generation of water- soluble cannabinoids in yeast, and other plant cell suspension cultures as well as novel water- soluble cannabinoid compounds. The present inve...
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WO/2019/007146A1 |
Provided are an aminotransferase, a mutant, and applications of the aminotransferase and the mutant in preparation of sitagliptin. According to the applications, bacteriophages obtained by performing fermentation culture on recombinant e...
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WO/2019/001548A1 |
Provided is a method for preparing fucoxanthin by fermental cultivation of Nitzschia laevis, comprising the following process steps: step A: preparation of a seed solution; step B: fermental cultivation: transferring the seed solution to...
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WO/2018/229305A1 |
The invention relates to norcoclaurine synthases and substrate binding sites having one or more site-specific mutation which increase the activity, when compared to the wild type synthase, of the condensation of 4-HPAA and dopamine to (S...
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WO/2018/229322A1 |
The present invention relates to an enzymatic composition and the development of an enzymatic cascade for the production of 2,5-furanodicarboxylic acid (FDCA) from 5-methoxymethylfurfural (MMF). The cascade is triggered by oxidation of M...
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WO/2018/218903A1 |
A method for preparing troxerutin ester using whole cell catalysis, which falls within the fields of biological catalysis and pharmaceutical chemistry. The method specifically comprises the following steps: evenly mixing troxerutin and a...
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WO/2018/217855A1 |
The present disclosure includes genetically engineered, non-pathogenic Streptomyces bacterium with exogenous, non-native Thaxtomin A (ThxA) biosynthetic gene clusters conferring the genetically engineered, non-pathogenic Streptomyces bac...
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WO/2018/212626A1 |
The present invention relates to a recombinant microorganism having an enhanced ability to produce heme, coproporphyrin III (Copro III), and uroporphyrin III (Uro III), and a method for producing heme, coproporphyrin III, and uroporphyri...
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WO/2018/212624A1 |
The present invention relates to a 11-lipoxygenase consisting of the amino acid sequence represented by SEQ ID NO: 1; or a composition for producing 11-hydroxyfatty acid, hepoxilin D3, or trioxilin D3, comprising the 11-lipoxygenase and ...
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WO/2018/207930A1 |
A recombinant microorganism is provided which has a gene encoding pyridoxine oxidase and a gene encoding pyridoxamine synthetase having enzymatic activity for synthesizing pyridoxamine from pyridoxal, wherein the gene encoding pyridoxine...
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WO/2018/207931A1 |
A recombinant microorganism is provided which has a gene encoding pyridoxine dehydrogenase, a gene encoding pyridoxamine synthetase having enzymatic activity for synthesizing pyridoxamine from pyridoxal, and a gene encoding an amino acid...
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WO/2018/207888A1 |
The present invention provides a method for simply and efficiently producing ramelteon, which is a sleep-inducing agent. According to the present invention, ramelteon can be produced through a few steps including a step in which (E)-2-[1...
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WO/2018/205563A1 |
A method for producing tetrahydropyrimidine by fermenting recombinant Corynebacterium glutamicum. The recombinant Corynebacterium glutamicum is obtained by overexpressing, in Corynebacterium glutamicum, an aspartokinase gene lysC of whic...
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WO/2018/206590A1 |
The invention provides a novel class of natural azaphilone pigments, called atrorosins, and methods for their production. The methods for the production of atrorosins include production by fermentation using a fungal species belonging to...
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WO/2018/205846A1 |
A method for extracting highly-effective natural plant anthocyanidin, which relates to the technical field of bioengineering. The method comprises the steps of: hydrolyzing anthocyanin; by using sodium bicarbonate or potassium bicarbonat...
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WO/2018/204859A1 |
In an aspect, the disclosure provides methods for making neurotransmitters in a host organism. The neurotransmitters can be cannabinoids and derivatives of cannabinoids. The host cells can be microalgae, fungi or other host cells. In a r...
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