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WO/2002/092830A1 |
The present invention relates to a method for preparation of androst-4-ene-3,17-dione (AD) and androsta-1,4-diene-3,17-dione (ADD). More particularly, the present invention relates to a method for preparing AD/ADD, comprising the steps o...
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WO/2002/086142A1 |
It is intended to provide a novel process for producing soyasapogenol B which is useful as a drug or a material for producing drugs. Sophoradiol employed as a starting material is treated with a hydroxylase originating in a plant to ther...
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WO/2002/072758A2 |
The invention features isolated cytochrome P450 polypeptides and nucleic acid molecules, as well as expression vectors and transgenic plants containing these molecules. In addition, the invention features uses of such molecules in method...
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WO/2002/061109A2 |
The invention concerns genetically modified yeast strains autonomously producing steroids from a simple carbon source. The invention also concerns a method for producing steroids from said yeast strains.
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WO/2002/053722A1 |
The present invention relates to ginsenoside glycosidase which hydrolyzes high content saponin glycosyl in ginseng for preparing rare saponin with high physiological activity, where the said ginsenoside glycosidase is derived from microb...
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WO/2002/046386A2 |
The present invention relates to a novel cytochrome P450-like enzyme ($i(Aspergillus ochraceus)) isolated from cDNA library generated from the mRNA of $i(Aspergillus ochraceus) spores. When the cDNA encoding the 11 alpha hydroxylase was ...
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WO/2002/027013A1 |
It is intended to provide synthetic reaction conditions for producing edible sterol fatty acid esters having physiological activities from plant-origin sterols and fatty acids or fats and oils by using lipase as a catalyst, and edible st...
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WO/2002/020727A2 |
The present invention provides a solid state fermentation (SSF) method which is effective for both small- and large-scale fungal cultivation. The present invention also provides SSF media for fungal cultivation. Although the SSF method p...
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WO/2002/012536A1 |
The invention concerns novel yeast strains, methods and genetic constructs for preparing them, and their use for synthesising or modifying steroid compounds. More particularly, the invention concerns strains having reduced 20$g(a)-HSD ac...
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WO/2001/081612A1 |
A process for producing soyasapogenol B which comprises culturing a microorganism belonging to the genus Neocosmospora or Eupenicillium in a medium containing a glycoside having soyasapogenol B as the aglycon and then collecting soyasapo...
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WO/2001/075083A1 |
The invention relates to a process for the selective alcoholysis of a free sterol, by contacting said free sterol with a fat-based product, optionally with the addition of carboxylic fatty acid(s) and/or ester derivative(s) thereof that ...
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WO/2001/066773A2 |
This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, ...
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WO/2001/053512A1 |
The present invention provides a method for extracting lipids from microorganisms without using a nonpolar organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microo...
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WO/2001/053511A1 |
Candida antarctica lipase A is effective for esterifying sterols with carboxylic acids, whereas C. antarctica lipase B and several other lipases are inactive. The invention provides a process for preparing a carboxylic acid ester compris...
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WO/2001/031050A1 |
A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein multiple genes involved in steroid nucleus degradation are inactivated, such as steroid dehydrogenase genes. Examples for such g...
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WO/2001/025469A2 |
The invention concerns a method for producing hydroxylated and/or acetylated steroid comprising steps which consist in: culturing yeasts on a medium comprising at least a precursor of such hydroxylated and/or acetylated steroids; then is...
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WO/2001/004342A1 |
The present invention is an enzymatic $g(D)?1¿-dehydrogenation of 6-methyleneandrost-4-ene-3,17-dione (II) to produce 6-methyleneandrosta-1,4-diene-3,17-dione (III) which is a useful pharmaceutical agent.
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WO/2000/073483A2 |
A process for the preparation of desglucodesrhamnoruscin which comprises the enzymatic hydrolysis of Ruscus aculeatus steroid glycosides (ruscosaponins) by means of crude hydrolases from Aspergillus niger.
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WO/2000/073489A1 |
A process for the preparation of desglucodesrhamnoruscin which comprises the hydrolysis of Ruscus aculeatus steroid glycosides (ruscosaponins) through fermentation of a substrate containing said glycosides by means of fungi of the Asperg...
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WO/2000/050621A2 |
A process for producing aldehydes, and/or carboxylic acids is described, in which a primary alcohol, especially a carbohydrate, is oxidised using a catalytic amount of a nitrosonium compound obtained by oxidising a nitroxyl compound in t...
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WO/2000/050388A1 |
A process for producing nitrosonium ions is described, in which a nitroxyl compound such as TEMPO is oxidised using an oxidising agent in the presence of a complex of a transition metal such as Mn, Fe, Cu, and a complexing agent such as ...
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WO/2000/036132A1 |
Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or no...
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WO/2000/015831A1 |
A process for producing an ursodeoxycholate at a high yield which comprises adhering and immobilizing an anaerobic enteric bacterium capable of $g(b)-hydroxylating the keto-group at the 7-position of bile acid (i.e., capable of producing...
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WO/1999/049075A1 |
A novel process for the fermentation of phytosterol compositions to androstenedione (androst-4-ene-3, 17-dione, AD) and/or androstadienedione (androsta-1, 4-diene-3, 17-dione, ADD) is disclosed. The process utilizes the micro-organism $i...
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WO/1999/040203A1 |
The invention concerns a modified yeast strain wherein the acetyl-CoA pregnenolone acetyl-transferase activity (APAT) is eliminated by alteration of the gene coding for said activity and which results in stabilisation of the 3$g(b)-hydro...
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WO1998020151A9 |
Disclosed is a method for the production of an adrenocorticoid steroid represented by general formula (I), wherein R1 and R3 may be H, alkyl, substituted alkyl, silyl, acyl, acyloxy or carbamoyl (and wherein R1 need not be the same as R3...
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WO/1999/016886A1 |
The invention relates to a method for producing ergosterol and intermediate products thereof by means of recombinant yeasts and plasmids for transforming yeasts.
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WO/1998/045457A1 |
Plant phytosterol compositions are modulated in transgenic plants to confer resistance to insects, nematodes, fungi, and/or other environmental stresses, and/or to improve the nutritional value of the plants. Recombinant DNA molecules of...
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WO/1998/025948A2 |
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of formula (I) wherein: -A-A- represents the group -CHR?4�-CHR?5�- or -CR?4�=CR?5�-...
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WO/1998/026055A1 |
The invention relates to immobilized proteins from crude extracts and their use for fermentation in bioreactors.
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WO/1998/020150A1 |
A process for preparing a practical cholesterol-lowering compound by converting the cholesterol contained in a food or feed to coprostanol having very low intestinal absorption by utilizing an enzymatic action. The content of cholesterol...
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WO/1998/017789A1 |
The invention relates to isolated DNA fragments or recombinant DNA constructs containing at least part of a sterol glycosyl transferase coding sequence. Substances used as sterols are either sterols in the strictest sense (cholesterol, e...
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WO/1998/004676A2 |
A fortified enzyme preparation of the gorgonian $i(Pseudopterogorgia americana) or $i(Pseudopterogorgia elisabethae) has been developed which efficiently transforms a variety of precursor molecules, e.g., sterols, to their corresponding ...
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WO/1997/049829A1 |
A biological process for preparing 25-hydroxylated steroids which comprises adding a steroid (except cholesterol) to microbial cells of an amycolata or sphingomonas capable of hydroxylating steroids at the 25-position or a culture thereo...
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WO/1997/038005A1 |
An antifungal and antilipemic agent comprising substance MK6059 of the following general formula (I) which is prepared by culturing a MK6059 strain belonging to the genus Ellisiodothis in a conventional nutrient medium for microbes, and ...
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WO/1997/037664A2 |
Use is provided for a 7'alpha'-hydroxy or 7-oxo substituted 3'beta'-hydroxy-steroid possessing the carbon skeleton of cholesterol, androsterone, pregnenolone or estradiol, or an analogue thereof substituted independently at one or both o...
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WO/1997/036997A1 |
A microorganism having a capability of introducing a 7'beta'-hydroxyl group into a 7-unsubstituted bile acid, and a process for preparing a bile acid having a 7'beta'-hydroxyl group characterized by bringing the above microorganism into ...
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WO/1997/027314A1 |
A process for producing oleanolic acid analogs which comprises inducing and culturing hairy roots originating in a plant capable of forming oleanolic acid analogs (such as myricerol, 27-hydroxy-caffeoylmyricerol, myricerone or 27-hydroxy...
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WO/1997/021720A2 |
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of formula (I), wherein: -A-A- represents the group -CHR4-CHR5- or -CR4=CR5-; R3, R4 and R5...
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WO/1997/021830A1 |
The invention relates to a microbial method of in vitro transformation of a steroid into its corresponding 11'alpha'-hydroxy analogue using oxygen and a microorganism selected from Aspergillus ochraceus, Aspergillus niger, Rhizopus stolo...
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WO/1997/008336A1 |
A process for producing at least one hydroxycholesterol selected from the group consisting of 25-hydroxycholesterol, 17,25-dihydroxycholesterol and 25,26-dihydroxycholesterol via the biological hydroxylation of cholesterol; and the dihyd...
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WO/1996/025512A1 |
A Chrysosporium strain No. CBS 123.95, mutants and derivatives thereof, and a method for preparing non-peptide compounds using said strain, are disclosed. Novel compounds of general formula (I), pharmaceutical compositions containing sam...
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WO/1996/015253A1 |
The invention relates to a process for producing 1-hydroxymethyl-1.4-androstadiene-3.17-dione of formula (I), in which 1-methyl-1.4-androstadiene-3.17-dione of formula (II) is fermented with a living culture of a microorganism of the gen...
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WO/1996/012034A1 |
The present invention relates to a microbiological process for the transformation of 17'beta'-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5'alpha'-reductase.
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WO/1995/030009A2 |
Polypeptides with saponin glycosyl hydrolase activity, including avenacinase and tomatinase, have been purified and encoding nucleic acid therefor cloned and manipulated. The nucleic acid is useful in production of the polypeptides, for ...
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WO/1995/018142A1 |
The invention relates to new compounds, WF15604 substances or salts thereof, having antifungal activity and inhibitory activity on cholesterol biosynthesis, to a process for the preparation thereof and to a pharmaceutical composition com...
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WO/1994/029453A2 |
Disclosed is a new gene which codes for a NADPH cytochrome P450 oxidoreductase from filamentous fungi. Also disclosed are a recombinant DNA molecule which comprises at least a part of that gene, an RNA molecule derived therefrom and a ne...
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WO/1994/029434A1 |
Fusion enzymes having multiple segments of different biological activity including one segment having P450scc activity and at least one segment having electron-transfer activity for transferring electrons to P450scc are described along w...
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WO/1993/025702A1 |
A process for producing a substance which lowers the cholesterol level in a cholesterol-containing substance by converting the cholesterol into epicholesterol; novel cholesterol oxidase and novel epicholesterol dehydrogenase; a process f...
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WO/1993/021205A1 |
A method is provided for isolating 5,7-diene-containing steroids, particularly 3 beta-ols and esters of 3 beta-ols, from a sterol mixture. The method involves (1) treating the mixture with a dienophile or with an oxidizable dienophile pr...
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