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JP4443636B2 |
A subject of the invention is a modified yeast strain in which the acetyl-CoA pregnenolone acetyltransferase (APAT) activity is eliminated by altering the gene coding for this activity with resultant stabilization of 3beta-hydroxysteroids.
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JP2010507375A |
The present invention relates to novel yeast. More specifically, a novel yeast that is enriched for Vitamin D. In one aspect, the invention comprises a yeast that retains its gassing power after UV irradiation and that can be used to pro...
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JP4417838B2 |
Disclosed is a new synthetic pathway for the production of precursors for the production of compounds having general formula (8,10,12). During said synthesis, compounds of general formal (4,B) are produced in a microbiological reaction. ...
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JP4404710B2 |
An object of the present invention is to provide a process according to which 5-ene-3-one or 3,6-dione derivatives of sterols can be synthesized with a better yield, as well as a process for production of lipid metabolism improvers, food...
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JP2009219379A |
To provide a DNA variant encoding a polypeptide concerned with hydroxylation of vitamins D, to provide a transformant holding the DNA variant, and to provide a method for producing a hydroxylated vitamin D derivative using the transforma...
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JP2009161485A |
To provide a terpenoid derivative having excellent lipolysis actions with weak adverse effects, and to provide a method for producing the derivative.The terpenoid derivative having the lipolysis actions has -1 to -800 mV oxidation-reduct...
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JP2009523434A |
The invention relates to the use of bacterial strains of the species Amycolatopsis mediterranei for the microbial transformation of 9ß,10a-steroids of general Formula (I) to their corresponding 11ß-hydroxyl analogues, as well as to spe...
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JP2009131171A |
To efficiently and readily provide a 4-campestenone-containing composition or a composition containing the 4-campestenone as an active ingredient, which have antiobesity activity.A method for producing the 4-campestenone-containing compo...
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JP4234799B2 |
1- or 6-hydroxylated steroids of formula (I) are new. Either R1 = H and R2 = OR6; or R1 = OR6 and R2 = H; R5, R6 = H or 1-12C acyl (optionally substituted by one or more halo); R3 = 1-12C alkyl; R4 = 1-4C alkyl; wavy lines indicate that ...
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JP4223668B2 |
To provide a relay transmission type optical transmission system which can both collectively and efficiently detect a cable disconnection and identify disconnected cable, thus eliminating the problem in the conventional optical transmiss...
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JP4216183B2 |
A protein which comprises a 638 (II), 633 (IV), or 618 (VI) residue amino acid sequence, given in the specification, a protein with not less than50 % homology with (II), (IV) or (VI), and saponin-digesting activity, and a protein based o...
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JP4210437B2 |
According to the present invention, there is provided a process for enzymatically producing dietary sterol fatty acid esters having physiological activities from phytosterols and fatty acids or oils and fats using lipase as a catalyst; t...
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JP2009000103A |
To obtain a P450scc (side chain cleavage cytochrome P450) enzyme highly active for the P450scc enzyme which is an important enzyme for catalyzing a first stage of biosynthesis of an industrially useful steroid hormone.A sterol side chain...
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JP4169977B2 |
An objective of the present invention is to provide a method of producing soyasapogenol B and to provide novel microorganisms. The present invention provides a method of producing soyasapogenol B comprising the steps of culturing microor...
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JP2008212137A |
To provide gisenoside Rd, Rg2 and Rh1 produced by liquid culture of mycelium of Phellinus linteus strain (Phellinus linteus, KCTC 0912BP) with excellent gisenoside biotransformation activity, and to provide a method for producing the sam...
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JP4146897B2 |
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group -CHR4-CHR5- or CR4-CR5- R3, R4 and R5 are ...
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JP4147038B2 |
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JP2008201718A |
To provide a method for preparing a lipid from a lipid precursor that is hydrophobic with an extremely high lipid yield.The method for preparing a lipid (A) from a lipid precursor (a) using a microorganism is characterized by comprising ...
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JP4096614B2 |
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JP2008100996A |
To synthesize epoxymexrenone and an epoxymexrenone-based compound.Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone compounds of the formula I, wherein: -A-A- re...
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JP4082469B2 |
A DNA or RNA sequence coding for a delta-5,7 sterol delta-7 reductase (DSDR) protein is new.
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JP4076098B2 |
Process for preparing the compound 11beta-21-dihydroxy-2'-methyl-5'betaH-pregna-1,4-dieno[17,16
-d]oxazoline-3,20-dione of formula (I):which comprises adsorbing said compound, contained into an aqueous solution resulting from fermentatio...
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JP4057765B2 |
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JP4038643B2 |
A novel process for the fermentation of phytosterol compositions to androstenedione (androst-4-ene-3,17-dione, AD) and/or androstadienedione (androsta-1,4-diene-3,17-dione, ADD) is disclosed. The process utilizes the micro-organism Mycob...
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JP4020642B2 |
The present invention provides a method for extracting lipids from microorganisms without using a nonpolar organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microo...
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JPWO2005033305A1 |
Methods for producing alkaloid biosynthetic intermediates and methods for producing alkaloid biosynthetic intermediates, including inhibiting the expression of enzymes using the desired alkaloid biosynthetic intermediate as a substrate u...
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JP2007295848A |
To find out a yeast accumulating a steryl glucoside at a high concentration from yeasts safe even when ingested by humans. The yeast belonging to the genus Kluyveromyces and characterized as comprising ≥1 mg/g of the steryl glucoside b...
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JP4008263B2 |
To realize an oxidation activity for the degradation of cholesterol and a new function related with the synthesis of a useful substance and associated with the degradation of the cholesterol. A function-modified cholesterol oxidase in wh...
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JP2007531516A |
The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, phosphatidic acid phosphatases (PAP)) and/or lipid acyl hydrolase (LAH) activity, nucleic a...
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JP4005325B2 |
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JP2007181432A |
To provide a new enzyme for phosphorylating 22 position of ecdysteroid and its gene and to provide a method or the like for simply and inexpensively producing a phosphoric acid conjugate of the ecdysteroid by using the enzyme.The invento...
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JPWO2005063227A1 |
In the present invention, callus derived from banaba, biwa, perilla or guava is cultured with indol acetic acid and other plant hormones, and from the cultured callus, corosolic acid, tolmentic acid, 2α, 19α-dihydroxy- Provided is a me...
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JP2007515932A |
The present invention relates to a two part microbial process for the preparation of 7-oxo-5-androstene steroids of Formula III.
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JP3917069B2 |
To provide a method for efficiently producing in high purity 7α-hydroxy-pregna-4-en-3-one-20-carbaldehyde useful as an intermediate for synthesizing pharmaceuticals including squalamine. This method for producing 7α-hydroxy-pregna-4-en...
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JP3917021B2 |
To provide a method for producing 7α-hydroxy-pregna-4-en-3-one-20- carbaldehyde, by which the 7α-hydroxy-pregna-4-en-3-one-20-carbaldehyde useful as a raw material for synthesizing medicines such as squalamine can efficiently be produc...
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JP2007507219A |
The present invention relates to a microbial method for the simultaneous dehydrogenation and oxidation of 4-an-drosten-3,17-dione to produce 17a-oxo-D-homo-1,4-andrustadiene-3,17-dione in high yield and high substrate concentrations, by ...
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JP2007044040A |
To provide a lanosterol synthesis enzyme originated from a plant, and to provide a method for using the enzyme.A gene encoding a protein comprising one of the following amino acid sequences. (1) A specific amino acid sequence; (2) an ami...
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JP3862277B2 |
Bacillus sp. TTUR 302 which belongs to the genus Bacillus and is capable of converting bile acids having a 7 alpha -hydroxyl group or a 7-keto group into bile acids having a 7 beta -hydroxyl group ; and a process for producing bile acids...
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JP2006340718A |
To provide a method for the enzymatic synthesis of 12-ketokenodeoxycholic acid with an NAD-dependent enzyme.An oxidation reaction is brought about by adding a catalytic amount of NAD+ and NAD-dependent 12α-hydroxysteroid dehydrogenase (...
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JP2006314248A |
To provide a new method for producing a triterpene derivative expressed by formula (II) and usable as a synthetic intermediate for medicines by a biological conversion method.A triterpene derivative used as a starting material is incubat...
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JP3839994B2 |
To obtain sterol-fatty acid esters and specific vitamins without practically applying an organic solvent by making an esterase act on a mixture comprising specific vitamins, sterols, fatty acids or the like to selectively form the sterol...
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JP2006520349A |
The disclosed invention relates to sterol and/or stanol esters of ethercarboxylic acids corresponding to general formula (I):R(OAlk)nOCH2COOH, in which R is a C1-50 alkyl, alkenyl and/or alkylphenyl group derived from an alcohol, OAlk st...
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JP2006520204A |
The present invention relates to a method for the production of ergosta-5,7-dienol and/or its biosynthetic intermediates and/or metabolites by culturing genetically modified organisms, and to the genetically modified organisms, in partic...
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JP3814284B2 |
This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I,
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JP2006515518A |
A process to produce 19-nor-10beta-carboxylic acids by fungal oxidation of 6-substituted-Delta6-pregnanes is disclosed.
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JP2006131595A |
To obtain a safer and more effective carcinogenesis preventing agent particularly containing a cycloartane-type triterpene compound.The carcinogenesis preventing agent contains at least one cycloartane-type triterpene compound selected f...
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JP2006129836A |
To provide an efficient method for constructing a library containing various kinds of compounds by using a biocombinatorial technique.The method for constructing the compound library uses a plurality of enzyme molecular species. As a res...
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JP3768226B2 |
To provide a method for producing 1α-hydroxyvitamin D by directly converting only one H atom on the 1α-position to a hydroxy group in vitamin Ds bearing H atoms on the 1α- and 25- positions. A vitamin D is treated in a solution contai...
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JP2006508660A |
This invention relates to lactic fermenting products of ginseng obtained by fermentation of ginseng using lactic acid bacteria, yoghurt containing said lactic fermenting products of ginseng, and lactic acid bacteria used in the preparati...
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JP3756538B2 |
PURPOSE: To obtain a new ergosterol analog, having suppressing actions on the seed formation of plants and useful as a suppressant, etc., for the seed formation of the plants useful as a nontoxic herbicide by extracting the analog from a...
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