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WO/2024/059517A1 |
Described herein are CB5 polypeptides for the biosynthesis of oxygenated hydrocarbons in modified host cells.
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WO/2024/025465A1 |
Disclosed herein are methods of obtaining ferulic acid. In one aspect, the present disclosure refers to a method of hydrolysing oryzanol to obtain ferulic acid, wherein the method comprises: i. hydrolysing an oryzanol-comprising material...
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WO/2024/003514A1 |
The present invention relates to a biosynthetic route to precursors of the QS-7 molecule, as well as routes to make the QS-7 molecule, enzymes involved, the products produced and uses of the product.
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WO/2024/003012A1 |
This invention relates to methods of producing triterpenoids using one or more of (i) Saponaria officinalis β-amyrin synthase (SobAS) (ii) S. officinalis C28 oxidase (SoC28) (iii) S. officinalis C28C16 oxidase (SoC28C16) (iv) S. officin...
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WO/2023/173565A1 |
Provided is a method for simultaneously enhancing and inhibiting multiple key genes during synthesis of 7-dehydrocholesterol in Saccharomyces cerevisiae by means of a dCpf1-VP activation system and a dCas9-RD inhibition system. In order ...
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WO/2023/140608A1 |
The present invention relates to the preparation of a recombinant strain to which a gene coding for a recombinant photosynthetic enzyme into which squalene epoxidase and cytochrome P450 reductase are translationally fused, a gene coding ...
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WO/2023/122801A2 |
The present invention relates inter alia to methods of biosynthetic production of QS-21, precursors and variants thereof, and to related aspects.
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WO/2023/103365A1 |
Provided are four engineering yeasts, which are respectively engineering yeast CE-P1 capable of synthesizing calenduloside E, with a deposit number of CGMCC No. 23731, engineering yeast IVA-P1 capable of synthesizing chikusetsusaponin IV...
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WO/2023/089317A1 |
The present invention relates to genetically-modified oleaginous yeasts for producing non-native sterols at commercially useful levels, especially for example in providing sterols individually or as a mixture in an artificial dietary com...
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WO/2023/083359A1 |
Provided are a glycosyltransferase OsUGT91C1 mutant and the use thereof. An amino acid sequence as shown in SEQ ID NO:. 1 is obtained by means of mutating an amino acid at position 208 from Phe to Met on the basis of the amino acid seque...
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WO/2023/075295A1 |
The present invention relates to a variant of (Ruminococcus gnavus strain-derived 7 beta-hydroxysteroid (7-beta-HSDH), improving a conversion rate from 7-keto lithocholic acid (7-keto-LCA) to ursodeoxycholic acid (UDCA), and a method for...
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WO/2023/065558A1 |
A method for preparing a ginsenoside preparation by using bioengineering technology, the method comprising: (1) selecting a composite biological enzyme preparation, which is prepared by means of fermentation via the combined bacteria of ...
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WO/2023/066002A1 |
A method for preparing a ginsenoside preparation by adopting a bioengineering technology. The ginsenoside preparation comprises at least one of a saponin-rich preparation and saponin-rich syrup. A composite bio-enzyme preparation prepare...
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WO/2023/060761A1 |
The present invention relates to the technical field of genetic engineering, in particular to an engineering strain of nannochloropsis oculata, and a preparation method therefor and the use thereof. The engineering strain is nannochlorop...
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WO/2023/035469A1 |
The present invention relates to the field of biotechnology, in particular to a saringosterol synthetase, and a preparation method therefor and the use thereof. The saringosterol synthetase of the present invention can be used to efficie...
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WO/2023/039518A1 |
The disclosure provides compositions and methods related to engineered microbial cells, enzymes, and methods for producing dammarenediol, as well as compounds derived from dammarenediol. Microbial host cells are engineered to express a h...
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WO/2023/006109A1 |
Provided in the present invention are a highly specific glycosyltransferase for rhamnose, and the use thereof. A specific glycosyltransferase is disclosed in the present invention for the first time, which glycosyltransferase can catalyz...
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WO/2023/278976A2 |
Provided herein include methods of making mogroside compounds, e.g., siamenoside I 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and composi...
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WO/2022/212917A1 |
Described in this application are proteins and host cells involved in methods of producing isoprenoid precursors and/or isoprenoids.
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WO/2022/212924A1 |
Described in this application are proteins and host cells involved in methods of producing mogrol precursors, mogrol, and/or mogrosides.
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WO/2022/166648A1 |
The present invention relates to a method for using compartmentalization to increase the yield of 7-dehydrocholesterol in yeast. In the present invention, yeast is used as a starting strain, and heterologous sterol â–³24-reductase and â–...
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WO/2022/115710A1 |
7β-hydroxylation systems are provided, as well as methods for producing ?P-hydroxy derivatives of lithocholic acid and 3-keto-lithocholic acid from such systems. Also provided are recombinant organisms useful for the production of such ...
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WO/2022/101282A1 |
The present invention relates to methods using recombinant Thauera aromatica cells to produce oxygen-independent molybdenum-hydroxylases in order to convert vitamin D3, 7-dehydrocholesterol and related alkylated compounds into 25-hydroxy...
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WO/2022/060057A1 |
The present invention relates to a novel Aspergillus niger AG1 strain and, more specifically, to: a method for preparing β-glycosidase, comprising a step of culturing the strain; a method for preparing compound K, comprising a step in w...
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WO/2022/049074A1 |
The present invention refers to a method to produce methane or at least one other synthesis product by methanogenic microorganisms in a microbial electrolysis cell (MEC), while applying a separated nutrient feeding supply in a discrete o...
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WO/2022/023155A1 |
The present invention refers to a microbiological process for the preparation of ursocholic acid, which includes the biotransformation of β-sitosterol in the presence of specific microorganisms.
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WO/2021/252411A2 |
Provided are biosynthetic processes for producing sterol derivatives, and to non-naturally occurring organisms capable of producing sterol derivatives. More specifically, genetically modified non-naturally occurring organisms for produci...
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WO/2021/237950A1 |
Provided by the present invention is a process for manufacturing an artificial bear bile powder; by means using a transformation solution containing cellular active substances, the invention solves the technical problems of complex and c...
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WO/2021/231728A1 |
Described in this application are UDP-glycosyltransferases (UGT) enzymes, host cells expressing the UGTs, and methods of producing mogrol precursors, mogrol, and/or mogrosides using such host cells.
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WO/2021/176066A1 |
The present invention relates to a process for preparing a steroid, comprising the step of reacting a 7-desoxysteroid with a Cytochrome P450 enzyme or a functional variant thereof in the presence of at least one redox partner system and ...
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WO/2021/176068A1 |
The present invention relates to an enzyme and a process for hydroxylating a 7-desoxysteroid of the general formula (I) in position 7 to a steroid of the general formula (II).
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WO/2021/139395A1 |
Disclosed is a high-efficiency low-toxicity anti-cancer compound synthesized by autocatalysis in cells and living bodies. The anti-cancer compound is prepared by means of chemical synthesis of a metal complex precursor and an organic act...
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WO/2021/110101A1 |
Provided is a method for preparing deapioplatycodin D, which is characterized in that two or more strains are used for simultaneous preparation, comprising a pichia kudriavzevii strain and a bacillus velezensis strain, so as to prepare t...
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WO/2021/098506A1 |
A steroid 5β reductase variant and an application therefor. The steroid 5β reductase variant has steroid 5β reductase activity, and the amino acid sequence of the variant includes R63K and R64H mutations. The variant can use NADH as a...
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WO/2021/085997A1 |
The present invention pertains to: a composition for producing ursodeoxycholic acid (UDCA), the composition containing a deep eutectic solvent, a 7 alpha-hydroxy steroid dehydrogenase (7αHSDH), and a 7 beta-hydroxy steroid dehydrogenase...
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WO/2021/081327A1 |
The disclosure relates to enzymes, such as cucurbitadienol synthase (CDS), UDP- glycosyltransferase (UGT), Cll hydroxylase, epoxide hydrolase (EPH), squalene epoxidase (SQE), and/or cytochrome P450 reductase enzymes, recombinant host cel...
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WO/2020/222717A1 |
The invention is related to an AG-08 coded novel structured molecule having cytotoxic features against cancer cells. The aim of the invention is to primarily synthesize the astragenol (AG) molecule from cycloastragenol (CA) and then from...
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WO/2020/215265A1 |
A method for preparing a mixture of rare ginsenosides Rh3 and Rk2 and a mixture thereof. In the method, Rg3 is used as a raw material, β-glucosidase is used for enzymatic preparation, an acidification reaction is performed after an enzy...
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WO/2020/161317A1 |
The present invention concerns a genetically modified bacterium and to its industrial application, in particular in the 1,2-dehydrogenation of steroids.
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WO/2020/155058A1 |
A method for preparing a radix codonopsis extract from a radix codonopsis leftover material, comprising: first adding water, cellulose, and β-glucosidase in the radix codonopsis leftover material; uniformly mixing and carrying out enzym...
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WO/2020/137706A1 |
[Problem] The purpose of the present invention is to provide a new method for producing a cycloastragenol analog from astragaloside IV. {Solution] A method for producing a cycloastragenol analog that includes a contact step that brings a...
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WO/2020/108327A1 |
A method of preparing tauroursodeoxycholic acid by biotransformation and an application thereof, comprising genetic codon optimization, engineered bacteria construction, engineered bacteria cultivation, substrate transformation, and prod...
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WO/2020/096905A1 |
Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions...
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WO/2020/097588A1 |
Described in this application are enzymes (e.g., cucurbitadienol synthases (CDS), UDP- glycosyltransferases (UGT), C11 hydroxylases, epoxide hydrolases (EPH), squalene epoxidases, and/or cytochrome P450 reductases), host cells expressing...
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WO/2020/096907A1 |
Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example, host cells) for making mogroside compounds, and the mogroside compounds made by the methods and compositions disclosed herein, co...
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WO/2020/076819A1 |
Genetically-modified cell capable of producing UDCA, cholic acid, and/or another UDCA precursor comprising at least one heterologous polynucleotide encoding an enzyme involved in a metabolic pathway that converts sugar to UDCA, cholic ac...
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WO/2020/072908A1 |
Aspects of the invention provide methods for producing one or more secondary metabolites from microbial culture. In various embodiments, the method comprises culturing a microbial cell producing a secondary metabolite for recovery from a...
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WO/2020/030799A1 |
A genetically-modified bacterium, for example of the class Actinobacteria, and the use of such a bacterium in the bioconversion of a steroidal substrate into a steroidal product of interest. A method of converting a steroidal substrate i...
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WO/2020/027456A1 |
The present invention relates to a novel Ceriporia lacerata-K1 strain (accession number KACC 83018BP, a culturing method therefor, and a composition comprising a culture thereof as an effective ingredient for prevention or treatment of d...
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WO/2020/022847A1 |
The present invention relates to a recombinant yeast strain having sterol productivity, a preparation method therefor and a use thereof and, more specifically, to: a recombinant yeast strain capable of producing cholesterol and cholester...
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