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WO/2004/026902A1 |
The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum, to vectors which comprise such a nucleic acid molecule, to Acremonium chrysogenum host cells which have been trans...
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WO/2004/020650A2 |
An enzymatic process under kinetical control for preparing b-lactams, by coupling the 7-amino group of a cephalosporin nucleus with the carboxylic function of an acetic acid derivative consisting of a residue with p-electrons, a short sp...
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WO/2004/020572A2 |
The present invention discloses a bioreactor apparatus with an expandable surface area which is useful for culturing cells. A method for culturing cells is also included in the invention. The method comprises providing a container and a ...
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WO/2004/020651A1 |
An enzymatic process under kinetical control for preparing β-lactams, by coupling the 7-amino group of a cephalosporin nucleus with the carboxylic function of an acetic acid derivative consisting of a residue with &pgr -electrons, a sho...
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WO/2004/020649A1 |
An enzymatic process under thermodynamical control for preparing b-lactams, by coupling the 7-amino group of a cephalosporin nucleus with the carboxylic function of an acetic acid derivative consisting of a residue with p-electrons, a sh...
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WO/2004/020652A2 |
An enzymatic process under kinetical control for preparing ß-lactams, by coupling the 7-amino group of 7-ACA with the carboxylic function of TZH activated as methyl- or ethylester. The process comprises using a penicillin amidase or a-a...
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WO/2003/076640A2 |
A process for the preparation of cephalosporin acid derivatives comprises the step of enzymatically converting cephalosporin C into 7 cephalosporin acid derivatives in the presence of two biocatalysts, wherein one biocatalyst comprises c...
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WO/2003/064613A2 |
This invention provides amidases, polynucleotides encoding the amidases, methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides enzymes having secondary amidase activity, e.g., having ac...
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WO/2003/062430A1 |
The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the ho...
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WO/2002/085914A2 |
A process for preparing cephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C compound of formula (III) into a 3-thiolated-$g(a)-ketoadipyl-7-aminocephalosporanic acid derivative o...
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WO/2002/086143A2 |
An enzymatic process for preparing 3-thiolated 7-aminocephalosporanic acid derivatives comprises the steps of enzymatically converting a 3-thiolated cephalosporin C of the formula (I), to form a 3-thiolated-glutaryl-7-ACA of the formula ...
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WO/2002/085913A1 |
A penicillin and cephalosporin compound having a phenylacetic acid or phenoxyacetic acid content of 100 ppm or lower; and a process for producing a penicillin and cephalosporin compound which comprises extracting two or more times phenyl...
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WO/2002/072806A2 |
Variants of glutaryl amidase are described and a process for the preparation of 7−aminocephalosporanic acid using the same.
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WO/2002/024879A2 |
The invention provides a glutaryl 7-ACA amidase from Pseudomonas diminuta strain BS-203, which catalyzes the hydrolysis of 7-$g(a)-(4-carboxylbutanamido)-cephalosporanic acid to 7-aminocephalosporanic acid and glutaric acid. The inventio...
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WO/2002/024865A2 |
Disclosed are methods for the modulation of secondary metabolite production by fungi through genetic manipulation of such fungi. Also disclosed are new commercial processes using ZBC proteins, or variants thereof, to significantly increa...
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WO/2002/020819A2 |
An enzymatic process for the preparation of a semi-synthetic $g(b)-lactam antibiotic compound by reacting an N-substituted $g(b)-lactam with two enzymes, namely a penicillin acylase and an $g(a)-amino acid ester hydrolase or microorganis...
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WO/2002/018618A2 |
The invention relates to a process for the preparation of an aqueous solution or suspension of a $g(b)-lactam nucleus and application thereof. The aqueous solution or suspension of the $g(b)-lactam nucleus is prepared by process wherein ...
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WO/2001/098518A2 |
The invention relates to a method for producing biologically active ingredients. Active ingredients comprising additional functional groups, a modified spectrum of activity and modified application properties can be obtained from medicam...
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WO/2001/085951A1 |
Penicillin expandases modified to improve the ring-expanding activity for a substrate which is other than the natural substrate of the unmodified expandase and in particular expandases such as penicillin N expandase having increased spec...
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WO/2001/066767A2 |
The present invention concerns the direct production of desacetylcephalosporin C by culturing a strain of Acremonium chrysogenum containing recombinant nucleic acid encoding Rhodosporidium toruloides caphalosporin esterase.
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WO/2001/032904A2 |
An method for enhancing the secretion of a $g(b)-lactam compound from a micro-organism is described, together with an isolated polynucleotide encoding the ABC transporter protein responsible for said enhanced secretion. Furthermore an is...
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WO/2001/029073A1 |
The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for...
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WO/2000/078989A1 |
The method is based on the utilization of desacetoxycephalosporin C (DAOC) directly produced by fermenting Acremonium chrysogenum (also called Cephalosporium acremonium) and catalyzing it by enzymatic activities D-amino acid oxydase (DAO...
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WO/2000/073490A1 |
The invention relates to a method for delaying the deactivation of glutaryl amidase during an enzyme catalysis. The enzyme catalyst is separated off by filtration after maximum reaction of the substrate and can be re-used in a subsequent...
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WO/2000/071547A1 |
A process for the preparation of Cefuroxime acid (I), which comprises the following steps: (1) Extraction of deacetyl 7-glutaryl ACA (II) aqueous solution at acid pH with organic solvents (for example according to the procedures disclose...
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WO/2000/066751A1 |
The present invention provides an expression cassette comprising a DNA sequence of a species encoding a protein which is combined with a DNA sequence encoding a secretion signal peptide of an A. faecalis species. The sequence of the spec...
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WO/2000/061767A1 |
The invention relates to an extracellular protease from $i(Acremonium chrysogenum) with CPC-acetyl hydrolase activity and its utilization in the synthesis of deacetylated derivatives of cephalosporin C and the inactivation of the gene fo...
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WO/2000/037671A2 |
The present invention discloses a process for the production of 7-amino cephalosporanic acid (7-ACA) or a derivative thereof comprising the steps of fermenting a $i(P. chrysogenum) strain being transformed with an expression construct co...
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WO/1999/060102A2 |
The invention provides DNA, heterologous host cells capable of transcribing, translating or expressing said DNA and methods employing such host cells and cultures thereof for an improved $i(in vivo) production of acylated cephalosporins ...
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WO/1999/055881A1 |
An isolated cephalosporin deacetylase derived from a strain of $i(Bacillu sp.) which (i) has an optimum pH between 8.0 and 9.0; (ii) has an optimum temperature of about 40 °C; and (iii) has an isoelectric point of about 4.3, and a DNA s...
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WO/1999/054476A1 |
The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular, the invention defines reaction conditions...
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WO/1999/050271A1 |
A method for the recovery of an N-substituted cephalosporanic acid compound of general formula (I), wherein R¿2? is selected from the group consisting of adipyl (1,4-dicarboxybutane), succinyl, glutaryl, adipyl, pimelyl, suberyl, 2-(car...
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WO/1999/038982A1 |
The present invention relates to a nucleic acid molecule which codes for the cephalosporin acetylesterase from Bacillus subtilis ATCC 6633 (DSM 11909), vectors and host cells which comprise such a nucleic acid molecule, a process for the...
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WO/1999/034774A1 |
The present invention discloses a method for topical application of an enzyme, wherein the enzyme becomes incorporated in a peelable film, for instance a polyvinyl alcohol film, after its application. In this way, the release of enzyme-c...
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WO/1999/033994A1 |
Three-dimensional crystal structure(s) of deacetoxycephalosporin C synthase (DAOCS) are described. The X-ray co-ordinates provide precise 3-dimensional information of amino acids within the structure of DAOCS. Some of these are in comple...
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WO/1999/032113A1 |
The present invention provides a method for targeting toxic antimetabolites to gram negative infections. It provides a means of taking advantage of a key disease resistance mechanism to activate these drugs locally, and to overcome the r...
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WO/1999/031109A1 |
The invention relates to complexes of cephradine and cefaclor and 1-naphthol. It has been found that 1-naphthol shows better complexing behaviour then for example 2-naphthol. The invention also relates to a process for the preparation of...
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WO/1999/020786A1 |
Process for the preparation of a $g(b)-lactam antibiotic in which a $g(b)-lactam nucleus is subjected to an enzymatic acylation reaction with the aid of an acylation agent at a molar ratio of acylation agent/$g(b)-lactam nucleus of less ...
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WO/1999/015532A1 |
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between 3 and 8 at a temperature between -5 and 20 °C and ...
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WO/1999/015531A1 |
Process for recovery of a $g(b)-lactam antibiotic from a mixture containing $g(b)-lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between (3) and (8) at a concentration such that FG remains...
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WO/1999/015632A1 |
Enzymatic process for the preparation of cephalosporanic 7$g(b)-(4-carboxybutanamide) acid by using the modified enzyme D-aminoacid oxidase of $i(Trigonopsis variabilis) produced in $i(Escherichia coli). The process for the expression of...
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WO/1999/013098A1 |
Lactams, for example 6-aminopenicillanic acid (6-APA), may be prepared by enzymatic conversion of a first compound, for example penicillin-G, in a solvent mixture comprising water and a non-aqueous organic solvent, especially 1,1,1,2-tet...
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WO/1999/013058A2 |
A process for decreasing esterase activity present in the presence of D-amino acid oxidase activity or in the presence of glutarylacylase activity in a mixture having esterase activity and D-amino acid oxidase activity and/or having este...
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WO/1999/001566A1 |
An improved method has been provided for the enzymatic bioconversion of $g(b)-lactam compounds by the application of a preparation of an enzyme or enzymes with a low level of $g(b)-lactam degrading activity. Especially the application of...
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WO/1999/001561A1 |
The present invention discloses an enzyme obtainable from $i(P. chrysogenum) which is an O-acetyl-L-serine sulfhydrylase (OAS sulfhydrylase). It is shown for the first time that $i(P. chrysogenum) contains an enzyme activity associated w...
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WO/1998/056944A1 |
Disclosed is a method to improve the quality of enzymatic hydrolysis or synthesis of the substituted $g(b)-lactam compounds with respect to enzyme productivity, product quality and process streamlining (prevention of the formation deposi...
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WO/1998/056945A1 |
The invention relates to a process for enzymatically preparing a $g(b)-lactam antibiotic from a $g(b)-lactam nucleus or a salt thereof and a precursor for a side chain, wherein a large amount of enzyme is used, which amount is at least t...
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WO/1998/048038A1 |
The invention relates to a method for preparing a $g(b)-lactam antibiotic, wherein an $i(N)-substituted $g(b)-lactam, having general formula (I), wherein R�0? is hydrogen or C�1-3? alkoxy; Y is CH�2?, oxygen, sulfur, or an oxidized...
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WO/1998/048036A1 |
The present invention relates to a novel process for the preparation of cephalosporins having been deacylated at the 7-amino group, by fermentation of a cephalosporin producing microorganism in the presence of a side chain precursor, ext...
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WO/1998/047594A2 |
According to a first liquid purification method, the liquids to be purified are brought into contact with the aerogels from a liquid phase acting as adsorption agents during a time period which is long enough to enable adsorption of impu...
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