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Document Title |
JP2540143B2 |
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved i...
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JPH08242884A |
To obtain penicillin and cephalosporin that are stable and can be readily purified in high yield by carrying out the reaction of 6-amino-penicillanic acid or 7-amino-cephalosporanic acid with an amide in the presence of an immobilized pe...
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JPH08208484A |
To obtain the formulation containing a specific amount of cefaclor as an active ingredient, further containing excipients and coadjuvants, and suitable for the direct compression manufacture of dispersible tablets for treating the infect...
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JPH08506814A |
Provided is a process for isolating cefaclor from an acylation reaction mixture by adding anthraquinone-1,5-disulfonic acid to the mixture. The acid highly selectively precipitates with cefaclor so that isolation and recovery is streamli...
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JPH0898686A |
PURPOSE: To obtain the subject new enzyme having a specific amino acid sequence as a form of a precursor before processing into α-subunit and β-subunit in a host cell and capable of decomposing cephalosporin C into 7- aminocephalospora...
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JPH0889281A |
PURPOSE: To obtain glutarylaminodeacetylcephalosporanic acid useful as a synthetic raw material for cephalosporin antibiotics or the like easily efficiently in high yield by making deacetylcephalosporin C contact with catalase and D-amin...
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JPH0829114B2 |
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JPH088877B2 |
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JPH08284A |
PURPOSE: To obtain a cephalosporanic acid derivative in high yield without generating waste liquor causing environmental pollution problem by reacting a specific cephalosporanic acid derivative with a chloroacetic acid lower alkyl ester ...
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JPH07250697A |
PURPOSE: To obtain in an industrially advantageous way the subject compound useful as an antibacterial agent, etc., by subjecting a diastereomer mixture of the 4-site ester of a specific 3-cephem-4-carboxylic acid derivative to an enzyme...
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JPH07507959A |
(57) [Summary] Since this publication is application data before electronic filing, summary data is not recorded.
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JPH07227296A |
PURPOSE: To acylate the subject compound useful as a raw material for antibiotics, etc., by reacting a specific cephalosporin compound with an acyl donor in the presence of a lipase or an esterase derived from Rodosporidium toruloides in...
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JPH0763356B2 |
The invention relates to a microbial process for the production of immunosuppressive cyclosporine antibiotic complex or of its components, cyclosporine A, cyclosporine B and cyclosporine C, by the aerobic fermentation of a filamentous fu...
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JPH0782274A |
PURPOSE: To provide a new cephalosporin compound having a specific structure, useful as a production raw material for various cephalosporin-type antibiotic substances and acting as an excellent substrate for cephalosporin C acylase. CONS...
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JPH07502168A |
PCT No. PCT/DK92/00388 Sec. 371 Date May 12, 1994 Sec. 102(e) Date May 12, 1994 PCT Filed Dec. 18, 1992 PCT Pub. No. WO93/12250 PCT Pub. Date Jun. 24, 1993.The present invention relates to an improved method for the preparation of certai...
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JPH0759591A |
PURPOSE: To obtain a deacetylcephalosporanic acid derivative useful as a production intermediate for a cephalosporanic acid-type antibiotic substance in high conversion by reacting a cephalosporanic acid derivative with a microorganism o...
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JPH07501207A |
Described is a method for the fermentative production of cephalosporin C, the fermentation solution being filtered during fermentation through a cross-flow filtration system. The filtrate obtained from the fermenter can be used again.
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JPH0699444B2 |
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JPH06315396A |
PURPOSE: To inactivate an esterase enzyme coexisting with D-amino acid oxidase in production of glutaryl-7-aminocephalosporanic acid by using D-hmino acid oxidase-containing substance derived from a microorganism capable of producing D-a...
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JPH06225794A |
PURPOSE: To efficiently obtain deacetylcephalosporin C useful as an intermediate, etc., for synthesizing β-lactam antibiotics by reacting an enzyme source derived from a microorganism which belongs to Pseudomonas and capable of deacetyl...
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JPH06189761A |
PURPOSE: To provide a process for inactivating an esterase existing together with a D-amino acid oxidase in an enzymatic conversion of cephalosporin C into glutaryl-7-aminocephalosporanic acid with the D-amino acid oxidase. CONSTITUTION:...
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JPH06172364A |
PURPOSE: To acylate 7-amino group of cephalosporanic ring. CONSTITUTION: A7-ACA amino thiazolyl protected adduct is prepared by acylating an amino group with aminothiazolyl acetic acid wherein amino group has been protected by a phenyl a...
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JPH06504947A |
The present invention relates to a process for separating, from each other, one non-dissolved catalyst from one or more other non-dissolved components present in a reaction mixture. The separation is obtained by using a catalyst having a...
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JPH06141857A |
PURPOSE: To obtain the subject new enzyme freed from dislocation activity, capable of producing 7-aminocephalosporanic acid by acting it on cephalosporin C. CONSTITUTION: The objective γ-glutamyltranspeptidase modified with a copolymer ...
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JPH06133770A |
PURPOSE: To provide a novel enzyme that hydrolyzes amino-methoxy-methyl- cephem-carboxylic ester to chemoselectively form amino-methoxymethyl-cephem- carboxylic acid in high yield. CONSTITUTION: This is an esterase that is suitable for t...
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JPH06125785A |
PURPOSE: To convert a deacetylcephalosporanic acid derivative into a cephalosporanic acid derivative by action of an enzyme. CONSTITUTION: A deacetylcephalosporanic acid derivative is treated with an enzyme (e.g. a fungus belonging to th...
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JPH06105682A |
PURPOSE: To provide a method for enhancing the production of a fermentable β-lactam antibiotic and to obtain a composition therefor. CONSTITUTION: This DNA sequence contains a reading frame encoding δ-(L-α- aminoadipyl)-cysteinyl-D-va...
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JPH0698795A |
PURPOSE: To convert a cephalosporanic acid lactone derivative into a 3- hydroxymethylcephalosporanic acid derivative by action of a microorganism. CONSTITUTION: A bacterium belonging to the genus Pseudomonas or Methylobacillus or its pre...
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JPH0612997B2 |
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JPH0646835A |
PURPOSE: To obtain a malonyl-7-aminocephalosporanic acid derivative and a 7-aminocephalosporanic acid derivative by using a microorganism. CONSTITUTION: A cephalosporin C derivative of formula I or its soluble salt is used as a raw mater...
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JPH0649075A |
PURPOSE: To efficiently obtain a 3-hydroxymethylcephalosporanic acid derivative useful as an intermediate, etc., for cephalosporin-based antibiotic substances in high yield under mild conditions by reacting a specific cephalosporanic aci...
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JPH0646862A |
PURPOSE: To obtain a gene useful for producing cephalosporin C. CONSTITUTION: A gene (cefG) encoding acetyl CoA: deacetylcephalosporin C acetyltransferase(DAC-ATF) of Cephalosporium acremonium has, for example, a nucleotide of the formul...
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JPH069517B2 |
Production of undesired desacetylcephalosporin C during fermentation of cephalosporin C-producing microorganisms is substantially reduced by addition of certain phosphorous compounds to the culture medium.
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JPH0614777A |
PURPOSE: To provide the novel enzyme useful for hydrolyzing cephalosporin C to produce aminocephalosporanic acid, and having a high enzymatic activity and a high processing effect. CONSTITUTION: An enzyme of the formula [A1-268 is an ami...
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JPH069649A |
PURPOSE: To obtain the subject compd. in high yield which is useful as an antibiotic by enzymatically condensing a reaction deriv. of an α-substd.-α-aminoacid and a cephalosphorin matrix. CONSTITUTION: A compd. expressed by formula I (...
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JPH05292961A |
PURPOSE: To obtain a new PNB esterase obtainable from a recombinant host cell, etc., in a purified form having extremely high specific activity from an extract of a bacterium of the genus Bacillus. CONSTITUTION: This PNB esterase in a su...
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JPH05276958A |
PURPOSE: To obtain a new DNA compound useful for producing a large amount of PNB esterase in a recombinant host cell. CONSTITUTION: This isolated DNA compound comprises a DNA sequence encoding PNB esterase activity of Bacillus subtilis a...
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JPH05199897A |
PURPOSE: To modulate the number and/or size of organelles by the treatment such an altering the expression of proteins existing in the organelles, thereby modulate the production of secondary metabolites such as of penicillin or cephalos...
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JPH0527395B2 |
A process for preparing a 7-aminocephalosporanic acid compound which comprises treating a cephalosporin C compound with an enzyme-producing microorganism belonging to the genus Pseudomonas or a material obtained by subjecting the microor...
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JPH0526461B2 |
PURPOSE:To improve the productivity of an antibiotic substance, by cultivating a miroorganism capable of producing the antibiotic substance under irradiation with light within a specific wavelength region. CONSTITUTION:A microorganism ca...
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JPH05501651A |
A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of beta -lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido...
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JPH0568551A |
PURPOSE: To obtain the subject enzyme having specific characteristics by isolating GL-7ACA acylase from Pseudomonas strain A14 followed by cloning and by transforming host cells with a vector containing a DNA coding the clone, and then c...
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JPH04365484A |
PURPOSE: To obtain the subject immobilized enzyme useful for producing a medicine as a catalyst for oxidative deamination, by incubating a solution of D-amino acid oxidase with porous beads comprising a vinyl acylate and/or vinyl alcohol...
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JPH0477754B2 |
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JPH0468919B2 |
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JPH04504362A |
An enzymatic process for the production of 7-amino cephalosporanic acid from cephalosporine C is disclosed. The process is a two-stage enzymatic reaction which can be performed in a single reactor. The invention further includes a mutant...
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JPH045438B2 |
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JPH044896A |
PURPOSE: To industrially and efficiently obtain the title cephalexin useful as an antibiotic in a biological method by adding penicillin acylase produced by the Xanthomonas to a reaction system. CONSTITUTION: When 7-aminodesacetoxycephal...
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JPH0378119B2 |
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JPH03254684A |
NEW MATERIAL:The cDNA compound coding a deacetylcephalosporin C acetyltransferase precursor originated from Acremonium chrysogenum. EXAMPLE: The cDNA compound coding the protein having the amino acid sequence of formula. USE: For example...
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