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JPH03206884A |
PURPOSE: To obtain a hydroxylase purified to electrophoretic uniformity, by subjecting a crude cell-free extract of hydroxylase by sound treatment to a specific treatment including a chromatography stage and eluting a linked protein. CON...
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JPH03187398A |
NEW MATERIAL: A cephalosporin C amidase having 37-40°C optimal temperature, optimal pH 7-8 and substrate specificity in the order of acetylcephalosporin C > cephalosporin C > desacetoxycephalosporin C. USE: One step conversion of cephal...
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JPH0348792B2 |
An improved strain of Acremonium chrysogenum may be produced by submitting parent strains of Acremonium chrysogenum to protoplast fusion and nuclear fusion and selecting said improved strain from the progeny or from a mutant thereof. The...
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JPH03133384A |
PURPOSE: To obtain a DNA compound encoding isopenicillin N:acylCoa acyltransferase activity and giving a gene related to the production of penicillins. CONSTITUTION: This DNA compound contains an isolated DNA sequence encoding the isopen...
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JPH0251594B2 |
Deacetylcephalosporin C is prepared by contacting cephalosporin C with an acetylesterase produced by a strain belonging to the genus Auresbasideum or a mutant thereof. Deacetylcephalosporin C is known as a valuable intermediate in synthe...
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JPH0246198B2 |
The present invention relates to a method for concentrating a dilute aqueous solution of a β-lactam antibiotic which is readily susceptible to heat, by subjecting a dilute aqueous solution of a β-lactam antibiotic, said solution contai...
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JPH02242675A |
PURPOSE: To synthesize deacetoxycephalosporin C synthase, by treating a cell extract of a crude enzyme adjusted to pH 7.5-8.0 in the presence of a reducing agent with an anion exchange resin in the presence of a reducing agent and a buff...
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JPH0240669B2 |
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JPH025396B2 |
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JPH022396A |
PURPOSE: To obtain 7-aminocephalosporanic acid by an efficient single-stage enzymatic deacylation process at a low cost by treating cephalosporin C with a cephalosporin C amidase originated from a specific microorganism. CONSTITUTION: Ce...
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JPH0158952B2 |
PURPOSE:In preparing antibiotics by cultivating microorganisms, to improve the productivity of antibiotics, by carrying out the cultivation under irradiation of light rays containing no ultraviolet light with <=a specific wave length. CO...
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JPH01304896A |
PURPOSE: To convert a β-lactam compound to other compound by protecting the carboxy group at 2nd position as the corresponding phenylacetyloxymethylester form, enzymatically hydrolyzing the compound and removing a protecting group. CONS...
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JPH0154998B2 |
A process for greatly improving the yields of cephalosporin nucleus produced by fermentation is described. Cephalosporin C-producing microorganisms are fermented in the presence of an acetylesterase enzyme so that cephalosporin C formed ...
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JPH01503037A |
The extraction of water soluble antibiotics containing a phenolic or carboxylic group from an aqueous solution or fermentation broth using a N-C8-C14 alkyl pyrrolidone extractant and the process involving the extraction of said antibiotic.
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JPH0147158B2 |
Deacetylcephalosporin C is prepared by contacting cephalosporin C with an acetylesterase produced by a strain belonging to the genus Auresbasideum or a mutant thereof. Deacetylcephalosporin C is known as a valuable intermediate in synthe...
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JPH01218599A |
PURPOSE: To enhance enzymatic biosyntheses at a low cost by bringing a cytoclasis preparation of an organism capable of producing ≥1 species of penicillin, cephalosporin and cephamycin to act on an amino acid mixture. CONSTITUTION: Cep...
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JPH0123473B2 |
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JPH0121149B2 |
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JPS6425785A |
NEW MATERIAL:The compound of formula I [R1 is lower alkyl; R2 is (protected) amino] or its salt. EXAMPLE: N-phthaloyl-3-acetoacetoxymethyl oganomycin E of formula II. USE: An intermediate for the production of a cephamycin-type compound ...
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JPS63301790A |
The present invention relates to DNA compounds and expression vectors that encode deacetoxycephalosporin C synthetase (DAOCS) and deacetylcephalosporin C synthetase (DACS) activities. The compounds can be used to construct recombinant DN...
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JPS63276498A |
A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase der...
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JPS6354715B2 |
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JPS6350356B2 |
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JPS6348520B2 |
Disclosed are optically active acylated cephalosporin analogs which are useful as antibacterial agents and methods for preparing such compounds.
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JPS63181996A |
Using a gamma -glutamyltranspeptidase which can be prepared by fermentation, it is possible to hydrolyse adipinyl- or glutaryl-monoamino compounds, in particular alpha -keto-adipinyl- or glutaryl-7-aminocephalosporanic acid.
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JPS63129995A |
6 beta -(3-Carboxyphenylacetylamino)-2 alpha -substituted-2 beta -methylpenam-3-carboxylic acids and 6 beta -adipoylamino-2 alpha -substituted-2 beta -methylpenam-3-carboxylic acids, wherein the alpha -substituent is C1-C3 alkyl, C1-C3 a...
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JPS6371174A |
Deacetoxycephalosporin C synthetase is provided in purified form via chromatography of crude cell-free extracts over a weak anion exchange resin followed by gel filtration and hydroxylapatite chromatography, all carried out in the presen...
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JPS6363393A |
N-(3-Carboxyphenylacetyl)-L-cysteinyl-D-valine and N-(3--carboxyphenylacetyl)-L-cysteinyl-D-modified-valine dipeptides are substrates for isopenicillin N synthetase conversion to penams e.g. 2-vinyl-2-methylpenam, 2-allenylpenam and 2-me...
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JPS6310708B2 |
A chemotherapeutic, antibacterial agent, 7 beta -[(2D-2-amino-2-carboxy)ethylthioacetamido]-7 alpha -methoxy-3-[(1-methyl-1H-tetrazole-5-yl)thiomethyl]-3-cephem
-4-carboxylic acid is produced economically and efficiently starting from ce...
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JPS6260079B2 |
This invention relates to certain novel alpha -amino- or alpha -formyl- alpha -(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.
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JPS6258716B2 |
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JPS6251117B2 |
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JPS6247519B2 |
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JPS6247516B2 |
Acrylonitrile polymer containing amino groups and having a porous structure containing micro-pores with an average size of from 50 to 2000 ANGSTROM and pore volume of not less than 0.2 cm3/g is prepared by reducing an acrylonitrile polym...
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JPS62224292A |
PURPOSE: To obtain cephamycin C in large production, by cultivating a bacterium belonging to the genus Streptomyces, containing specific genetric recombinant DNA in a medium. CONSTITUTION: Chromosome DNA of a bacterium such as Streptomyc...
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JPS6243679B2 |
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JPS62158492A |
PURPOSE: To obtain oganomycin E in high yield, by treating a cephamycin compound with yeast of Torulopsis genus or esterase originated from said yeast, etc. CONSTITUTION: A microbial strain belonging to Streptomyces genus and capable of ...
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JPS62501677A |
A Trigonopsis variabilis D-amino acid oxidase in substantially pure form and active against cephalosporin C. This D-amino acid oxidase is isolated from Trigonopsis variabilis by a method which is performed in three steps, namely: (a) aci...
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JPS6225358B2 |
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JPS62107798A |
PURPOSE: To obtain the titled compound useful as an intermediate for producing a cephalosporin antibiotic substance having antibacterial activity, etc., economically on an industrial scale, by reacting a specific cephalosporin compound w...
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JPS6219160B2 |
This invention relates to certain novel alpha -amino- or alpha -formyl- alpha -(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.
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JPS6230789A |
NEW MATERIAL:A compound expressed by formula I (R1 is carboxy or aminocarboxymethyl expressed by formula II; R2 is H or protecting group of carboxy group; R3 is 5- or 6-membered heterocyclic ring which may have a substituent group). EXAM...
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JPS61289889A |
PURPOSE: To produce a valuable substance using an enzyme, economically, preventing the deterioration of filtration membrane without lowering the rate of filtration, by filtering an enzymatic reaction liquid with an ultrafiltration membra...
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JPS6159318B2 |
PURPOSE:An SF-1623 substance derivative and its salt of formula I (R1 is H, SR3; R2 is amino, protected amino; R3 is aromatic group, heterocyclic group, acyl, group of formula II).
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JPS61268174A |
PURPOSE: To provide a microbial strain belonging to Streptomyces organonensis, deficient of sulfokinase and capable of economically producing organomycin B and cephamycin B useful as antibacterial agents. CONSTITUTION: A microbial strain...
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JPS6150955B2 |
This invention relates to certain novel alpha -amino- or alpha -formyl- alpha -(p-acyloxyphenyl)acetamidocephalosporanic acids which are useful as antibacterial agents.
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JPS61247382A |
A D-aminoacid transaminase which converts CPC with DELTA -keto acids into DELTA -ketoadipinyl-7-ACA can be isolated from Bacillus Licheniformis ATCC 9945. This transamination can be applied to other D-amino acids and can also be used for...
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JPS6149317B2 |
The interseparation of desacetyl-cephalosporin C, desacetoxy-cephalosporin C and cephalosporin C can be accomplished by adsorbing these available cephalosporins on activated carbon and effecting a fractional elution thereof with water co...
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JPS61158781A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS61137891A |
NEW MATERIAL:Cephem antibiotics, TAN-684A, B, C, D, E, F or their salts having following physical and chemical properties: molecular formula: A, C31H50 N8O13S; B, C34H55N9O15S; C, C37H60O16S; D, C41H69N11O16S; E, C44H74N12O17S and F, C47...
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