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WO/1996/040867A1 |
The present invention relates to a recombinant viral nucleic acid selected from a (+) sense, single stranded RNA virus possessing a native subgenomic promoter encoding for a first viral subgenomic promoter, a nucleic acid sequence that c...
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WO/1996/040975A1 |
A process for resolving a racemic (C>>3) alkyl (R, S) chroman-2-carboxylate compound useful as intermediates in the synthesis of optically pure pharmaceutical compounds is disclosed. The process utilizes a microbial enzyme derived from S...
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WO/1996/035775A1 |
New micro-organisms are capable of using as single nitrogen source piperazine 'alpha'-carboxylic acid amides in the form of their racemate or optically active isomers having general formula (I) and of transforming piperazine (RS)-'alpha'...
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WO/1996/034975A1 |
The present invention relates to a process for converting a racemic mixture of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters into the corresponding S-acid using lipase derived from Pseudomonas sp. The process provides the targe...
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WO/1996/030320A1 |
The present invention relates to a novel process for preparing cis-4-O-protected-substituted-2-cyclopentenol derivatives comprising, (a) dissolving a 4-O-protected-2-cyclopentenone in a suitable organic solvent; and (b) treating the solu...
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WO/1996/029426A1 |
Optical resolution of amino acid racemates and preparation of optically active amino acids with the use of a catalytic antibody which hydrolyzes amino acid ester derivatives enantioselectively; a catalytic antibody used therefor; and a h...
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WO/1996/028437A1 |
This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.
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WO/1996/027022A1 |
A new process is disclosed for preparing (R)-amines having the formula (I), in which R1, R2 and n have the meanings given in the description. For that purpose, racemic N-acyl-amines having the formula (II), in which R1, R2, R3 and n have...
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WO/1996/023894A1 |
A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates is characterised in that (a) a racemic heteroatom-substituted amine is enantioselectively acylated in the prese...
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WO/1996/020910A1 |
There is disclosed a method for optical resolution of 1,2-phenylethanediol, comprising the reaction of a racemic mixture of (R,S)-1,2-phenylethanediol, represented by formula (I), with an acetyl donor in the presence of an enzyme, to pro...
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WO/1996/020285A1 |
There is disclosed a method of producing a substantially enantiometrically pure compound from a precursor compound which is present in at least two enantiomeric forms wherein a transition metal catalyst is used to maintain an equilibrium...
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WO/1996/017077A1 |
A compound of formula (II), either as a single enantiomer or in an enantiomerically enriched form, wherein Het1 is (a) or (b), and Het2 is (c) or (d), and is (e) or (f) (wherein N in the benzimidazole moiety of Het2 means that one of the...
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WO/1996/017075A1 |
A process for producing sulphoxide enriched in the (R) or the (S) enantiomer as required comprises contacting a racemic mixture of such sulphoxide with the enzyme DMSO reductase derived from a bacterium selected according to the enantiom...
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WO/1996/017076A1 |
A compound of formula (II) is prepared either as a single enantiomer or in an enantiomerically enriched form, wherein Het1 is (a) or (b) and Het2 is (c) or (d) and X is (e) or (f) wherein N in the benzimidazole moiety means that one of t...
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WO/1996/012818A1 |
A process is disclosed that hydrolyzes, by the action of an epoxide hydrolase of Diplodia gossipina ATTCC 16391 or ATCC 10936, the undesired enantiomer of racemic indene oxide, an epoxide of indan.
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WO/1996/012028A1 |
The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthezised in plants at high levels by biologically conta...
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WO/1996/012035A1 |
This invention provides a process for enrichment of enantiomers of 'alpha'-tertiary carboxylic acid esters from mixtures of corresponding esters using a biocatalyst comprising microbial cells, or partially or highly purified enzyme prepa...
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WO/1996/011282A1 |
A process for resolution of a mixture of dihydroxydihydroindene enantiomers comprising treating the mixture of enantiomers with a Pseudomonas putida species microorganism. Resolved dihydroxydihydroindenes are valuable intermediates for t...
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WO/1996/002664A1 |
A process for the asymmetric synthesis of a compound represented by general formula (II-R) easily at a low cost by using a lipase, and a process for producing a compound to be utilized in the above synthesis.
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WO/1996/000296A1 |
A process for producing a D-amino acid from a DL-5-substituted hydantoin in one step readily and efficiently by using a composite immobilized enzyme preparation at a pH in the vicinity of neutrality, which preparation is produced by immo...
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WO/1995/034668A2 |
One aspect of the invention is to provide novel genetic constructions for the expression of inhibitory RNA in the cytoplasm of eukaryotic cells. The inhibitory RNA may be an anti-sense RNA or a co-suppressor RNA. The genetic construction...
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WO/1995/034525A1 |
An optically active 'alpha'-substituted carboxylic acid derivative represented by general formula (I) wherein R1 represents hydroxy, -C(=CH2)-COOR3 or -CH(CH3)-COOR3; R2 represents methyl or chloro; R3 represents hydrogen or C1-C6 alkyl;...
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WO/1995/033845A1 |
A process for stereoselectively obtaining an optically active O-acylpropargyl alcohol compound represented by general formula (2) (wherein R1 and R2 represent each hydrogen or C1-C3 alkyl; R3 represents phenyl which may be substituted by...
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WO/1995/032947A1 |
Enantiomeric glutarimides such as aminoglutethimide and rogletimide are prepared by cyclisation of a corresponding ester-nitrile which is a good substrate for biotransformation with an enantiospecific esterase.
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WO/1995/030740A1 |
A plant peptide amidase from the flavedo of oranges is known; this can be obtained only in small quantities and is seasonal. The proposed new enzymes are microbial peptide amidases which can be obtained from micro-organisms recovered fro...
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WO/1995/028385A1 |
A method is described for synthesis of N-protected amino acids, especially N-Boc-L-propargylglycine, a key intermediate used in the preparation of high-potency, orally-active renin inhibitors. This method involves reaction of an organic ...
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WO/1995/028374A1 |
A novel glycerol derivative and a process for producing the same, and a process for producing a triazole derivative. Specifically the invention provides an optically active 2-arylglycerol derivative that is novel and useful as an interme...
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WO/1995/023869A1 |
(R)-2-Amino-1-phenylethanol or a halogenated derivative thereof is produced by treating threo-3-phenylserine or an enantiomeric mixture of halogenated derivatives thereof with a tyrosine decarboxylase or a microorganism of the genus Ente...
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WO/1995/022620A1 |
Provided are enzymatic methods for the selective hydrolytic resolution of certain enantiomers of a pharmaceutical compound, the pharmaceutical compound comprising a (U) mixture of a 'alpha'-substituted 2-methyl propionic acid derivative....
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WO/1995/019373A1 |
Antibodies against Ins(1,4,5)P3, were raised by immunizing rabbits with two types of IP3-BSA conjugates which were synthesized by covalently coupling Ins(1,4,5)P3 to the carrier protein via alkyl linkages. The anti-Ins(1,4,5)P3 antibodie...
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WO/1995/016786A1 |
Process for the preparation of a threo-phenylserine amide of general formula (2) in which glycine amide is contacted with the corresponding substituted benzaldehyde of formula (3) in an excess relative to the amount of glycine amide, thi...
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WO/1995/013386A2 |
The present invention relates to a nucleic acid sequence encoding a fusion enzyme comprising a nucleic acid sequence encoding for a tyrosinase and a nucleic acid sequence encoding for a tyrosinase activator protein. Activator proteins us...
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WO/1995/012573A1 |
A novel azlactone of formula (3), or the opposite enatiomer, wherein R1, R2, R3 and X are each a substituent, undergoes biotransformation, using suitable enzymatic activity, in the presence of a base YH to form an N-acyl-amino-acid of fo...
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WO/1995/010604A1 |
An enzyme having acylase activity capable of hydrolysing N-acetyl-(R,S)-pipecolic acid stereo-selectively, to give (S)-pipecolic acid, wherein said activity is greater than that on N-acetyl-S-proline, at pH 7.5, 25 �C, and substrate co...
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WO/1995/008636A1 |
A process for producing optically active primary and secondary amines from the corresponding racemates is characterised in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid co...
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WO/1995/007359A1 |
A process for carrying out enzymatically catalyzed conversions of organic compounds comprises reacting an ester of an organic acid in a liquid organic phase with ammonia in the presence of a hydrolytic enzyme such as a lipase, esterase o...
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WO/1995/006746A1 |
A process for preparing acylated alcohols from alcohols is characterised in that the alcohol is reacted with a diketene in the presence of lipase. The process is particularly suitable for the enantioselective acetoacetylation of racemic ...
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WO/1995/006130A1 |
A process is disclosed for preparing (L)-2-chlorpropionic acid and its alkali, alkaline earth metal or ammonium salts. For that purpose, L-chlorpropionic acid isobutyl ester is hydrolysed at a pH value from 4 to 8 in the presence of a li...
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WO/1995/003421A1 |
The invention relates to a process for the preparation of optically active N-substituted-3-pyrrolidinol of general formula (1), wherein R represents a linear, cyclic or branched alkyl, alkenyl, aryl, alkaryl or aralkyl group, optionally ...
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WO/1994/025452A1 |
Disclosed is a process for preparing chiral compounds of formula (I) wherein: X1 and X2 are independently F or Cl; and E is -SO2R2, wherein R2 is C1-C6 alkyl, -C6H4CH3 or -CF3; its enantiomer and racemates thereof, useful in the synthesi...
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WO/1994/024305A1 |
Method of preparing an optically active compound of formula (I), wherein R and R1 are independently alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, aryl, aralkyl, a heterocyclic group or a C1-C4 alkyl-heterocycle, each being op...
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WO/1994/020634A1 |
An organism of the genus Ophiostoma or Ceratocystis, or a material having enzymatic activity derived therefrom, is used as a stereo-specific agent, in a biotransformation reaction, for the production of an enantiomeric acid or alcohol fr...
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WO/1994/020633A1 |
An organism of the genus Ophiostoma or Ceratocystis, or a material having enzymatic activity derived therefrom, is used as a stereo-specific agent, in a biotransformation reaction, for the production of (S_)-ketoprofen from a mixture of ...
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WO/1994/020635A1 |
A process for producing substantially pure R-ketoprofen by the enantioselective hydrolysis of racemic ketoprofen choline ester is disclosed. The process utilizes either intact Beauveria bassiana hyphae or an R-specific ester hydrolase is...
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WO/1994/019309A1 |
The invention relates to a method for the production of optically active glycerol derivatives having general formula (I), (IIa) or (IIb) where X represents an easily removable protecting group Y or a hydrogen atom, the protecting group Y...
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WO/1994/013828A1 |
Compounds having the formula: Ar-CHOR1-CHHal-COOR2 are useful as chiral synthons, for example in the synthesis of the anti-hypertensive agent diltiazem, and related calcium channel blocking agents. The synthons can be prepared in enantio...
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WO/1994/010334A1 |
A process for enantioselectively converting an aldehyde, a bisulfite adduct of an aldehyde or a glycidate to a chiral carboxylic acid is disclosed. The process utilizes a microorganism or an enzyme preparation from a microorganism and is...
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WO/1994/008030A1 |
A process for producing a D-alpha-amino acid represented by general formula (I), (wherein R represents phenyl, hydroxylated phenyl, substituted or unsubstituted alkyl, or thienyl) by treating an N-carbamyl-D-alpha-amino acid represented ...
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WO/1994/007887A1 |
The present invention relates primarily to the field of optically active lactones of formula (I) as defined below. The invention relates also to the utilisation of compounds of formula (I) so obtained as perfuming or flavoring ingredient...
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WO/1994/006930A1 |
Converting 2-alkyl nitriles of formula (1), wherein A and R1 are as defined in the text, to the corresponding 2-alkanoic acids; 2-alkyl nitriles to the corresponding amides; and 2-alkyl amides to the corresponding acids, all employing on...
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