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WO/1991/015470A1 |
A process is disclosed for the isolation of an enantiomerically enriched alcohol from a first mixture of an enantiomerically enriched 1-arylsulfonate-2-hydroxy-3-butene and an enantiomerically enriched 1-arylsulfonate-2-acyloxy-3-butene....
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WO/1991/013066A2 |
Method for the preparation of beta-phenylglycidic-(2R,3R) acid optionally in the form of salt or ester by precipitation of the salt of the beta-phenylglycidic-(2R,3R) acid with (+)-alpha-methylbenzylamine-(R) in a solution of a mixture o...
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WO/1991/013163A1 |
2-Arylpropionic acids such as ketoprofen, ibuprofen and naproxen can be stereospecifically resolved from their esters by hydrolysis using liver enzymes and particularly liver acetone powders derived from specific animals such as dog, pig...
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WO/1991/012221A1 |
A process for separating enantiomeric substances with the aid of a separating medium is characterised in that the substances are contacted with the separating medium, which consists of at least a cellulase enzyme, a derivative or a fragm...
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WO/1991/011186A1 |
The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparation...
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WO/1991/007501A1 |
Process for the pancreatic lipase mediated transesterification method for the optical resolution of endo-norborneol; derived optically active 5-(3-(exo-bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl)-3,4,5
,6-tetrahydropyrimidin-2(1H)-ones;...
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WO/1991/005870A1 |
A method for synthesizing D-alpha-amino acids by contacting under reaction conditions an alpha-keto acid corresponding to the D-alpha-amino acid, and a source of an amino group comprising an L-alpha amino acid or a DL-alpha-amino acid mi...
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WO/1991/004337A1 |
The S(-) and R(+) esters of 4-hydroxy-cyclopentene-1-one and its 2',2'-dimethylpropane 1',3'-diol-ketal are produced by direct, enantioselective, enzymatic synthesis by reacting the corresponding 4-hydroxy compounds with an ester as acyl...
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WO/1991/004334A1 |
R- and S-1-Phenyl-1,3-propanediol, each of high optical purity, were prepared by a chemoenzymatic sequence starting with ethyl benzoylacetate. The first step was a catalytic hydrogenation of the beta-ketoester conducted at room temperatu...
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WO/1991/002808A1 |
D-malic acid is produced from D,L-malic acid by subjecting the racemate to the action of a microorganism or product thereof which assimilates L-malic acid but not D-malic acid, until the L-malic acid in the racemate is substantially cons...
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WO/1991/002081A1 |
A method of producing D-pantolactone from DL-pantolactone, which comprises asymmetrically hydrolyzing only the D-enantiomer of DL-pantolactone selectively with a microorganism as specified in the claim to give D-pantoic acid, and convert...
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WO/1991/000923A2 |
A novel process for preparing antibacterial intermediates, such as for preparing the antibacterial compound thiamphenicol, is disclosed which utilizes a gamma-glutamyl hydrolase to selectively hydrolyze a racemic mixture of D-threo and L...
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WO/1991/000922A1 |
In a process for obtaining lower alkyl esters of R-(+)-3-oxocycloalkane carboxylic acids, the corresponding racemate undergoes hydrolysis at a pH between 7 and 8 in order to hydrolyse the unwanted enantiomer. The ester of interest can th...
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WO/1991/000362A1 |
Described is an enzyme process for the racemic separation of 4-aryl-2-oxo-pyrrolidine-3-carboxylic acid esters of general formula (I), in which X is a carbon-carbon bond or an oxygen atom; R�1? is a hydrocarbon group with up to 16 carb...
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WO/1990/015146A1 |
A lipase or lipase isozyme from Candida rugosa is used to stereoselectively hydrolyze esters, esterify acids or transesterify esters in aqueous/organic systems. Esters of 2-substituted acids such as 2-(4-hydroxyphenoxy) propionic acid, w...
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WO/1990/014434A1 |
A process for separating enantiomer esters in a racemic mixture of formulae (I) and (II) by hydrolyzing one of the enantiomer esters in the racemic mixture with an enzyme to its corresponding carboxylic acid. The enzyme is a protease der...
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WO/1990/013635A1 |
Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application...
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WO/1990/004643A1 |
This invention relates to a method for the production of (2R,3S)-3-(4-methoxyphenyl)glycidic acids and esters thereof, which are synthetic intermediate for the production of the calcium antagonist diltiazem. The method involves the stere...
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WO1990002192A1 |
A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate monoclonal antibody to the reactant under...
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WO/1990/000611A1 |
The present invention relates to the synthesis of a stereospecific enzyme by the non-chromosomal transformation of a host. The transformation is accomplished by a viral vector which is non-infective but which is self-replicating and whic...
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WO/1989/010410A1 |
An optically active 1,3-butanediol is prepared either by (1) treating a 1,3-butanediol enantiomer mixture with microorganisms capable of asymmetrically utilizing said mixture or a treated product thereof, or (2) treating 4-hydroxy-2-buta...
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WO/1989/009765A1 |
This invention relates to novel compositions of matter and their methods of preparation, which compositions are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters....
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WO/1989/002470A1 |
A process for synthesizing optically active compounds by asymmetric hydrolysis of a carbinol derivative having a fluorine atom or a fluoroalkyl group using an enzyme as a catalyst, which comprises immobilizing the enzyme on a honeycomb s...
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WO/1989/001525A1 |
Process for the racemization of an amino acid amide with general formula (I), the amino acid amide being brought into contact with an enzyme with amino acid amide racemase activity. In particular the invention relates to a process for en...
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WO/1988/009380A1 |
A phosphorous-containing analog-ligand having a stereoconfiguration that substantially corresponds to the stereoconfiguration of an amide- or ester-forming transition state is used to induce production of receptor molecules whose antibod...
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WO/1988/008838A1 |
New optically active compounds, namely optically active derivatives of 2-methyl-1,3-propanediol, have formula (I), where R is a C1-10 alkyl, in particular a C1-5 alkyl. A microbial process for their manufacture is also described. The com...
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WO/1988/008029A1 |
The method provides for the preparation of a compound having a controlled enantiomeric purity, respectively D-P or L-P, from a substrate S consisting of the oxidized form of the corresponding racemic D/L-P, or of said racemic D/L-P, or o...
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WO/1988/007582A1 |
This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel meth...
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WO/1988/006188A1 |
A process for preparing D-alanine, which comprises culturing a particular yeast belonging to any of the genera Candida, Saccharomycopsis, Pichia, Torulopsis, Cryptococcus, Hansenula or Trichosporon and capable of digesting L-alanine and ...
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WO/1988/003569A1 |
Process for producing optically active bicyclo[3.3.0]octandione carboxylic esters of formula (I), where R1 and R2 jointly represent an oxygen atom or the residue -O-X-O- with X having the notation of a straight or branched-chain alkylene...
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WO/1988/003570A1 |
Process for the manufacture of (-)-oxabicyclo[3.3.0]octanolones of formula (-)-I, where R is hydrogen or the residue (a), in which R1 has the notation of a hydrogen, alkyl with 1-7 C atoms, or phenyl. The process is characterized in that...
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WO/1988/003567A1 |
Process for the production of optically active (+)-bicyclo[3.3.0]octanol derivatives of formula (+)-I, in which R1 and R2 represent jointly an oxygen atom or the double-bond residue -O-X-O-, with X as a straight or branched-chain alkylen...
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WO/1988/003568A1 |
Process for the production of 3alpha-hydroxy-prostacyclin intermediates of formula (+)-I, where A is the residue -CH2- or >CH-COOR, B is oxygen or the double-bond residue -O-X-O- with X as a straight or branched-chain alkylene with 1-7 C...
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WO/1988/001298A2 |
The present invention overcomes problems of precipitating an intermediary complex and/or rapidly deactivating enzymes associated with known methods. It provides a membrane method for the enzymatic synthesis of peptides accomplished by sh...
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WO/1987/006266A1 |
Process for resolving racemic 1,2-dihydro-3H-pyrrolo[1,2a]pyrrole-1-carboxylic acid esters by enantiospecific hydrolysis utilizing extracellular lipases of microbial origin (EC 3.1.1.3) or extracellular microbial proteases.
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WO/1987/006269A1 |
A process for preparing optically active cyclopropanecarboxylic acids represented by formula (I), (wherein X represents a chlorine atom, a bromine atom, a methyl group or a trifluoromethyl group, and R' represents a hydrogen atom or a me...
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WO/1987/005328A1 |
A process for resolving racemic 3-acylthio-2-methylpropionic acid esters by enantiospecific hydrolysis utilizing extracellular lipases of microbial origin (EC 3.1.1.3). The desired chiral products can be readily converted to captopril.
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WO/1987/005329A1 |
Process for separating carbamate-racemates from aminoacids or norephedrin.
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WO/1986/007386A1 |
Optically active amino acids or amino acid amides can be prepared by converting an amino nitrile using an enantioselective nitrilase.
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WO/1985/004900A1 |
Process for resolving DL-carnitine by contacting a racemic mixture of DL-carnitine with a microorganism which preferentially metabolizes D-carnitine and permits accumulation of L-carnitine in the reaction medium and to a novel strain of ...
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WO/1985/003307A1 |
Processes for preparing optically-active 4-amino-3-hydroxybutyric acid by asymetrically cleaving one of the enantiotopic ester groupings of 3-hydroxyglutaric diester by the action of microbial enzymes to obtain a chiral monoacid which is...
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WO/1985/002414A1 |
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the for...
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WO/1984/004543A1 |
Process for preparing optically active alpha-cyanobenzyl alcohol compounds represented by formula (I), rich in an (S)-enantiomer useful as intermediates for synthesizing insecticidal pyrethroids, which comprises asymmetrically hydrolyzin...
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WO/1984/003714A1 |
A process for biochemical optical resolution of 4-hydroxy-3-methyl-2-(2'-propynyl)-2-cyclopentenone, which comprises allowing esterase produced by microorganism or esterase of animal pancreas to act on an organic saturated or unsaturated...
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WO/1980/002421A1 |
A racemic mixture of N-acetyl-D,L-phenylalanine methyl ester is provided and subjected to the action in an aqueous system of microbially derived serine proteinase. The N-acetyl-L-phenylalanine methyl ester is selectively converted to N-a...
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WO/1980/001571A1 |
This process for preparing L (Alpha)-amino-acid is characterized in that the corresponding racemic (Alpha)-amino-amid is hydrolysed in liquid phase in a free form or in the form of a salt, by an agent containing an L-stereospecific amida...
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JP2024038497A |
The present invention provides a method for epimerizing (S)-1-benzylisoquinoline alkaloid to (R)-1-benzylisoquinoline alkaloid. The method includes contacting a (S)-1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (...
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JP2024506887A |
Transaminase mutants and their applications are provided. The transaminase mutant is one obtained by generating one or more amino acid mutations in SEQ ID NO: 2, or by referring to SEQ ID NO: 1 of the wild-type CvTA transaminase and gene...
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JP2024503380A |
The present invention relates to methods for preparing linkers that are useful in the conjugation of therapeutic molecules (eg, cytotoxic agents) and targeting moieties (eg, proteins, peptides, antibodies, nanoparticles, nucleic acids). ...
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JP7401116B2 |
The present invention can produce an L-amino acid oxidase at a low cost and in a large quantity through a high expression of a recombinant protein, and the like, and provides a novel L-amino acid oxidase (ArtLAAO) having a wide substrate...
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