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WO/2003/005962A2 |
In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a furth...
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WO/2003/000909A2 |
The invention provides biocatalytic methods for the manufacture of pure single enantiomer compounds. The invention provides methods of screening for enzymes which are highly enantioselective or enzymes that can provide any desired stereo...
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WO/2003/000840A2 |
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increa...
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WO/2002/101003A2 |
The invention concerns a method for producing a cyclic L-amino acid of formula (I), characterised in that it consists in reacting a L-diamino acid of formula (II) or an enantiomeric mixture comprising such a L-diamino acid and a correspo...
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WO/2002/086126A2 |
The invention relates to an enzymatic method for the enantioselective reduction of organic keto compounds to the corresponding chiral hydroxy compounds, an alcohol dehydrogenase from Lactobacillus minor and a method for the enantioselect...
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WO/2002/085519A2 |
Compositions are provided herein comprising a base material having engrafted polymer brusches. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, whic...
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WO/2002/081626A2 |
The present invention relates to a novel D-hydantoinase from Ochrobactrum anthropi that enantio-selectively hydrolyzes D-hydantoins to their corresponding D-N-carbamoyl-amino acids; nucleic acids that encode for the enzyme; expression ve...
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WO/2002/077250A2 |
The present invention describes a process for the production of enantiomer-enriched $g(a)-substituted carboxylic acids with the assistance of the hydantoinase/carbamoylase enzyme system. The compounds to be used comprise substances of th...
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WO/2002/077212A2 |
The present invention relates to a new D-carbamoylase and the gene sequences which code for this from the organism Arthrobacter crystallopoietes DSM 20117. Plasmids, vectors, microorganisms, particular primers and specific possible uses ...
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WO/2002/072841A1 |
A process for efficiently producing an optically active amino acid from a 5-substituted hydantoin which comprises, from a bacterium belonging to the genus Microbacterium capable of converting the 5-substituted hydantoin into the opticall...
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WO/2002/070726A1 |
Treatment of a racemic lactate derivative with an enzyme having an ability to hydrolyze an ester asymmetrically causes specific hydrolysis of the ester moiety of one of the optical isomers constituting the racemic lactate derivative, and...
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WO/2002/070512A1 |
An optically active 2-azetidinone derivative which has a novel structure represented by the formula (II) is produced with ease, at a low cost and on a large scale, by a method comprising allowing an enzyme having the capability of the as...
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WO/2002/063028A1 |
A process for producing a compound represented by the following general formula (IV): (IV) wherein R represents hydrogen, alkyl or aryl; characterized by reducing a compound selected from the group consisting of compounds represented by ...
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WO/2002/061107A2 |
Process for the preparation of a chiral amino acid enriched in the D-enantiomer, in which a mixture of the enantiomers of the corresponding N-carbamoylamino acid is brought into contact with a D-carbamoylase with ammonia being liberated,...
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WO/2002/061077A1 |
A novel D-aminoacylase which is obtained by cloning a DNA encoding the novel D-aminoacylase from Methylobacteruim mesophilicum MT10894, etc. and which shows a sufficiently high activity at an industrially available substrate concentratio...
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WO/2002/059342A1 |
A method of producing (S)-3-[2-{(methylsulfonyl)oxy}ethoxy]-4-(triphenylmethoxy)-1
-butanol methane sulfonate using 1,3-butadiene and a ketoethanal to form an intermediate racemic mixture. The racemic mixture is resolved to remove one is...
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WO/2002/057411A2 |
The invention relates to hydrolases and to polynucleotides encoding the hydrolases. In addition, the invention relates to the use of these hydrolase enzymes in kinetic resolution.
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WO/2002/057475A1 |
This invention relates to a Chemoenzymatic process for the stereoselective preparation of both (R) and (S) enantiomers of 3-hydroxy-3-phenylpropanenitrile, useful as a key intermediate for synthesis of (S)-fluoxetine, (R)-tomoxetine and ...
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WO/2002/055724A1 |
A process for the preparation of 1-(3-trifluoromethylphenyl)-propan-2-ol enantiomersthrough enzymatic resolution by a lipase.
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WO/2002/053724A2 |
Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC?*¿(R)H-(CH¿2?)¿n?-O-C(&equals O)- where the substituents are as described below, the method comprising: contacting the protected hydroxide...
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WO/2002/050125A2 |
Glicosaminoglycans derived from K5 polysaccharide having high antithrombin activity and useful for the control of coagulation and as antithrombotic agents are obtained starting from an optionally purified K5 polysaccharide by a process c...
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WO/2002/048383A1 |
A novel process for producing an optically active (4R)-1,3-thiazolidine-4-carboxylic acid which comprises treating a mixture of (4R)- and (4S)-1,3-thiazolidine-4-carboxylic acid amides with optionally treated microbial cells having an ac...
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WO/2002/048322A2 |
The invention relates to biotechnologically expressible, enzymatically active recombinant porcine liver esterases, to a biotechnological method for the production thereof, and to their use in organic synthesis. The monomeric subunits of ...
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WO/2002/040438A1 |
The present invention relates to a process for the preparation of compounds of formula (1), wherein R¿1? is unsubstituted or substituted C¿1?-C¿8?alkyl or a radical of formula -COOR¿3?, wherein R¿3? is hydrogen or unsubstituted or s...
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WO/2002/036795A2 |
A process of separating a desired (-) stereoisomer which is selected from (-) menthol or an equivalent (-) compound where the isopropyl group is replaced with an isopropanol or an isopropylene group, from a starting material comprising: ...
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WO/2002/036803A1 |
A process for producing D-serine characterized by comprising bringing cells of a microorganism, which has been modified so as to exhibit an L-serine deaminase activity higher than the L-serine deaminase activity of Escherichia coli DH5a ...
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WO/2002/033110A2 |
An economical and expedient method is disclosed for the preparation of $g(a)-hydroxy-carboxylic acids or salts thereof in very high enantiomeric purity which comprises oxidizing a corresponding $g(a)-amino-carboxylic acid or salt thereof...
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WO/2002/028824A1 |
The present invention relates to compounds named Citrullimycines which are obtainable by cultivation of Streptomyces sp. ST 101396(DSM 13309), and to their pharmaceutically acceptable salts. The present invention further relates to a pro...
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WO/2002/029079A2 |
Enantioselective or enantiospecific nitrilases and nitrile hydratases are used to produce R or S enantiomers of amides, and carboxylic acids. R-amino acids and S-amino acids are produced using such enantioselective enzymes. In addition, ...
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WO/2002/022849A2 |
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer, (I), wherein Ar is C¿6? or C¿10? aromatic group that can be substituted with H, C¿1? to C¿6? alkyl, trifluoromethyl or hal...
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WO/2002/022844A1 |
(R)-N-(aminocarbonyl)fluorophenylalanine; and a process for producing (R)-N-(aminocarbonyl)fluorophenylalanine, characterized by treating 5-(fluorobenzyl)hydantoin with either an enzyme having the ability to selectively hydrolyze the (R)...
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WO/2002/020821A2 |
Process for the preparation of an enantiomerically enriched acylated amine, wherein an enantiomerically enriched, substituted or unsubstituted phenylglycine amide is contacted with a mixture of enantiomers of the corresponding amine H¿2...
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WO/2002/020820A1 |
Method for the preparation of an enantiomerically enriched acylated amine wherein a phenylacetic acid derivative is brought into contact with a mixture of enantiomers of an amine H¿2?NCR¿1?R¿2?R¿3?, in which R¿1?, R¿2?,...
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WO/2002/018560A2 |
The invention relates to novel proteins exhibiting esterase activity, in particular butinol I esterase activity, obtained from Pseudomonas glumae and to nucleic acid sequences that code therefor, expression cassettes, vectors and recombi...
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WO/2002/012472A1 |
An esterase isolated from Aspergillus oryzae is capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC 3.1.1.73). The esterase has only a limited homology...
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WO/2002/010422A1 |
The invention relates to a method for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of general formula (R)-II or (S)-II, where R = C¿1-4? alkyl, from 8-chloro-6-oxo-octanoic acid alkyl esters of general form...
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WO/2002/010399A1 |
Novel polypeptides capable of forming (S)-N-benzyl-3-pyrrolidinol, DNA encoding the same and a method of using the same. A polypeptide having the following physicochemical properties (1) to (5): (1) function: asymmetrically reducing N-be...
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WO/2002/008404A2 |
The invention relates to the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequences of human or animal lyso...
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WO/2002/008439A1 |
A process for the preparation of 2-amino acids of the general formula [II]: RCH(NH¿2?)COOH (wherein R is hydrogen, optionally substituted C¿1-6? alkyl, or the like), characterized by hydrolyzing a 2-aminonitrile of the general formula ...
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WO/2002/004384A2 |
A process of separating a single desired stereoisomer from a racemic mixture of eight stereoisomers of a compound of formula (III), wherein R¿1? represents an isopropanol group, an isopropyl group or an isopropylene group, includes the ...
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WO2001057232B1 |
The invention relates to a method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives.
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WO/2002/002753A2 |
The invention relates to a nucleotide sequence that encodes a benzaldehyde lyase and to the use thereof in a method for the stereoselective production of compounds that contain 2-hydroxyketone groups.
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WO/2002/000585A1 |
A process for efficiently producing an optically active chloropropanediol derivative, especially (S)-1-benzyloxy-3-chloro-2-propanol, which has a high optical purity and is useful as an intermediate for medicines. The process comprises t...
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WO/2001/092553A1 |
Disclosed is a method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid (alpha-HCCA) by taking advantage of enantioselectivity of enzymes. alpha-HCCA is reacted with alcohol to give a racemic alpha-HCCA est...
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WO/2001/092554A1 |
Disclosed is a method for preparing an R- or S-forms of alpha-substituted heterocyclic carboxylic acid (alpha-HCCA) and a counter enantiomeric form of alpha-substituted heterocyclic carboxylic acid ester thereto by use of an enzyme. A ra...
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WO/2001/090397A1 |
The invention relates to a process for converting an epoxide to an alcohol. The process according to the invention is enzymatically catalyzed and highly enantioselective and regiospecific.
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WO/2001/090130A1 |
The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (SS, RS)-S-adenosyl-L-methionine and allows to obtain the salified (RS)-(+)-S-adenosyl-L-methionine diastereoisomer in amounts lower t...
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WO/2001/090396A1 |
Method for the preparation of an enantiomerically enriched ester, in which a mixture of the enantiomers of the corresponding secondary alcohol is subjected, in the presence of an acyl donor, to an enantioselective conversion in the prese...
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WO/2001/083807A1 |
Stereoisomers of carbocyclic amine compounds such as amino tetralins are separated by subjecting a mixture of the stereoisomers to reaction with an acylating agent in the presence of the enzyme Pseudomonas capacia lipase which effect sel...
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WO/2001/073100A1 |
A process for the production of optically active $g(b)-amino alcohols of the general formula (II) which comprises treating an enantiomeric mixture of an $g(a)-aminoketone of the general formula (I) or a salt thereof with at least one mic...
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