Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 4,060

Document Document Title
WO/2021/047566A1
Disclosed are a preparation method for a compound as shown in formula (I) and levo-praziquantel. A racemate of ester of the compound of formula (I) is used as a substrate, and reaction is performed under the catalysis of immobilized lipa...  
WO/2020/255164A1
The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherei...  
WO/2020/224232A1
Provided are an Acinetobacter and the use thereof in the production of chiral 3-cyclohexene-1-formic acid. The taxonomic name of the Acinetobacter is Acinetobacter sp., and the Acinetobacter was deposited in the China General Microbiolog...  
WO/2020/216295A1
Provided is a method for resolving an optical isomer from a raceme by using supercritical fluid extraction technology. The method is mainly applied to the separation of a product obtained after enzymatic resolution. Taking a preparation ...  
WO/2020/218624A1
The present invention addresses the problem of providing a method for more easily and highly efficiently industrially producing high-purity L-cyclic amino acids from cyclic amino acids that have a double bond at the 1 position. According...  
WO/2020/214631A1
Methods for preparing crystalline L-glufosinate ammonium monohydrate are disclosed. The methods include forming a mixture comprising water, a water-miscible organic solvent, ammonium hydroxide, and a glufosinate starting material contain...  
WO/2020/208635A1
Systems and methods for processing organic waste, particularly mixed food waste, using a D-lactate oxidase are provided. The D-lactate oxidase eliminates D-lactic acid that is present in the organic waste. The processed organic waste can...  
WO/2020/196619A1
The present invention can produce an L-amino acid oxidase at a low cost and in a large quantity through a high expression of a recombinant protein, and the like, and provides a novel L-amino acid oxidase (ArtLAAO) having a wide substrate...  
WO/2020/183376A1
The present invention relates to an economical, enzyme catalyzed and commercially viable greener process for manufacturing Pregabalin of formula (I) in high yield with highchemical and chiral purity.  
WO/2020/173453A1
Disclosed is a method for resolving an optical isomer from a racemate by means of electrodialysis. Specifically, an electrodialysis technique is used in an enzymatic resolution process, mainly in the separation of products after enzymati...  
WO/2020/136236A1
The invention relates to a method and a device device for converting at least one reactant(5) into a reaction product and separating the at least one reactant from the reaction product, wherein the device comprises a vessel (10) with a v...  
WO/2020/119280A1
The present invention relates to the technical field of bioengineering and food, and relates to a method for enzymatic resolution of a chiral substance, comprising the following steps: (1) preparing an enzyme solution having a lipase con...  
WO/2020/107781A1
Disclosed is a novel method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-3-formic acid by enzymatic resolution. Said method comprises: using racemic 1,2,3,4-tetrahydroisoquinoline-3-formic acid or a salt thereof as a substrate, using...  
WO/2020/107780A1
Disclosed is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid by means of a chemoenzymatic method, comprising: using a racemic 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid as a substrate, stereoselectively ...  
WO/2020/089934A1
This invention relates to methods for racemization of dextro-rotatory ephedrine via enzymatic kinetic conversion, and is particularly useful for conversion of dextro- rotatory ephedrine (d- ephedrine) to racemic mixture of dextro-rotator...  
WO/2020/034660A1
Disclosed in the present invention is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-formic acid and derivatives thereof, comprising: using a raceme of a compound represented by formula (I) or a raceme of a salt of the compo...  
WO/2019/202038A3
Isosorbide-5-methacrylate was obtained by enzymatic catalysis with Lipozyme RM IM in a highly regioselective manner in up to 87% yield. The process uses readily available acyl donors (methacrylic anydride or vinyl methacrylate), is easil...  
WO/2019/225267A1
The purpose of the present invention is to provide a method whereby an optically active cis-aminopiperidine having a high purity can be produced without a need for protecting both of the two amino groups of aminopiperidine. The method ac...  
WO/2019/202038A2
Isosorbide-5-methacrylate was obtained by enzymatic catalysis with Lipozyme RM IM in a highly regioselective manner in up to 87% yield. The process uses readily available acyl donors (methacrylic anydride or vinyl methacrylate), is easil...  
WO/2019/197571A1
The present invention is directed to a process for the enantioselective biocatalytic preparation of 4-substituted 1-aminoindanes of general formula (S)-I: (l) and a process for the preparation of Ozanimod, preferably involving the enanti...  
WO/2019/184936A1
Disclosed in the present invention is a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and a derivative thereof. The method comprises: by using racemic 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (1) or ra...  
WO/2019/189724A1
Provided are: a novel hydrolase by which a (1S,2S)-1-alkoxycarbonyl-2-vinylcyclopropane carboxylic acid having a high optical purity can be highly efficiently produced at a low cost on an industrial scale; and a production method wherein...  
WO/2019/158558A1
A method for increasing the proportion of an enantiomer of undecavertol in an enantiomeric mixture of undecavertol, a method for stereoselectively synthesising undecavertol, and the products thereof.  
WO/2019/148494A1
Provided are a transaminase mutant and an application thereof. The amino acid sequence of the transaminase mutant is formed after mutation of the amino acid sequence as shown in SEQ ID NO: 1, and mutated amino acid sites comprise a T7C+S...  
WO/2019/141154A1
Disclosed is a production method of microbial biomass, comprising inoculating microorganisms in a controllable substrate liquid culture medium, performing pretreatment, and expanding and culturing the microorganisms under process conditi...  
WO/2019/128387A1
The present invention provides a method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid and a derivative thereof by using enzymatic resolution, the method comprising the step of: using racemic 1,2,3,4-tetrahydroisoquin...  
WO/2019/122421A1
The present application relates to processes for stereo- and regioselective reduction of cyclohexanones using a ketoreductase enzyme. Compounds prepared according to the disclosed processes are useful in the preparation of compounds for ...  
WO/2019/120000A1
Disclosed is a method for preparing a β-amino acid derivative rich in enantiomers, particularly a method for preparing sitagliptin. Blaise acid-base reaction, and an enzymatic reaction and a condensation reaction in any order are includ...  
WO/2019/063463A3
What is described herein relates to a method of selectively hydrolyzing an enantiomer of an alpha haloalkanoic acid according to formula I employing a polypeptide having dehalogenase activity comprising an amino acid sequence as set fort...  
WO/2019/063463A2
What is described herein relates to a method of selectively hydrolyzing an enantiomer of an alpha haloalkanoic acid according to formula I employing a polypeptide having dehalogenase activity comprising an amino acid sequence as set fort...  
WO/2019/028671A1
Provides is a method for preparing levetiracetam. The method comprises producing (R/S)-α-ethyl-2-oxo-1-pyrrolidine acetate under the action of an alkaline reagent using 2-bromobutyrate and 2-pyrrolidinone as raw materials, performing re...  
WO/2019/026800A1
Provided is a method that asymmetrically synthesizes a chiral carboxylic acid, through an enzymatic hydrolysis reaction mediated by at least one acylCoA esterase selected from the group consisting of ACOT7 and ACOT13, from the racemate o...  
WO/2018/220730A1
The present invention provides an industrially desirable novel cyclopentenone derivative, and a production method therefor. The novel compounds (the compounds represented by formula (i) and formula (I), and stereoisomers thereof) provide...  
WO/2018/219107A1
Provided are engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed are developed through directed evolution based on ...  
WO/2018/134710A1
The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method...  
WO/2018/103409A1
Disclosed are a methylocystis and the use thereof in the selective resolution and preparation of (S)-α-ethyl-2-oxo-1-pyrrolidine acetates. After cell immobilization of the enzyme-producing methylocystis, the methylocystis is applied to ...  
WO/2018/085906A1
The present invention relates to a method for obtaining a recombinant epoxide-hydrolase enzyme with a gene taken from the total genome of Streptomyces sp. bacteria B1 and subsequently expressed in E. coli genetically modified by the pGTE...  
WO/2018/088434A1
The purpose of the present invention is to provide a novel method for producing an N-succinyl-hydroxy-D-amino acid and/or a hydroxy-D-amino acid. A method for producing an N-succinyl-hydroxy-D-amino acid, said method comprising step (A) ...  
WO/2017/162667A1
The invention provides a new enzimatic process for the preparation of chiral carboxylic acids, their salts and acid derivatives of the general formula (I) by enzymatic hydrolysis of racemic carboxylic acid ester of the general formula (I...  
WO/2017/155025A1
Provided is a method for producing compound (1) or (6) by optical resolution using a specific hydrolase. (In the formula, R represents a protecting group of a carboxy group, R1 and R2 each independently represent a hydrogen atom or a pro...  
WO/2017/151573A1
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) are provided. The methods comprise a two-step process. The first step involves the oxidative deaminat...  
WO/2017/119514A1
[Problem] To provide a novel method for producing (2S, 3R, 4S)-4-hydroxyisoleucine. [Abstract] The present invention uses 4-hydroxyisoleucine dehydrogenase having one of the following substitutions in SEQ ID NO: 1: Arg is substituted wit...  
WO/2017/092197A1
Provided in the present invention is a method for the enzymatic resolution of an isavuconazole intermediate. Enantiomeric impurities in (2R,3S)-isavuconazole intermediate I are hydrolyzed to (2S,3S)-carboxylic acid by-product by nitrilas...  
WO/2017/038107A1
Provided are: a HasA-redoxin complex (a heme iron active-type HasA) which can asymmetrically oxidize only one of enantiomers of a secondary alcohol without the need of adding a coenzyme and has an asymmetric oxidization activity in an aq...  
WO/2017/033134A1
The present invention provides a process for the preparation of enantiomerically pure (R)- 1-(1-naphthyl)ethylamine of formula (IIa) by treating 1-acetylnaphthalene of formula (I) with R-selective transaminase enzyme in presence of amino...  
WO/2017/003721A1
The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product...  
WO/2017/001907A1
A process for preparing Vilanterol includes a biocatalytic conversion of a ketone substrate to its corresponding alcohol, and then converting the obtained alcohol into Vilanterol. Polypeptides may be used for the biocatalytic conversion ...  
WO/2016/208709A1
A method for producing a 1-(acyloxy)alkyl carbamate derivative (III) using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formulae: R1 represents a C1-...  
WO/2016/192694A1
The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-...  
WO/2016/130412A1
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzy...  

Matches 1 - 50 out of 4,060