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WO/2024/078646A1 |
A method for preparing (R)-tebuconazole by means of an enzyme chemical process, comprising: firstly, by taking the whole cell of recombinant bacterium E. coli/Rpeh expressing an epoxide hydrolase as a catalyst, resolving a racemic tebuco...
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WO/2024/041961A2 |
Described is a process for producing nearly enantiomerically pure (1R,2S)-2,6-dimethyl-1-indanamine, said process being characterized by the reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylating o...
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WO/2024/041629A1 |
The present invention provides a preparation method for R-type ketorolac and use thereof, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: step 1, preparing ketorolac; and ste...
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WO/2024/041962A1 |
Described is a process for producing nearly enantiomerically pure (1R,2S)-2,6-dimethyl-1-indanamine, said process being characterized by the reaction of a mixture of the four stereoisomers of 2,6-dimethyl-1-indanamine with an acylating o...
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WO/2024/013383A1 |
The present invention relates to a mutant ketoreductase, a nucleic acid encoding the mutant ketoreductase, a vector comprising the nucleic acid, a method for the enzymatic reduction of a prochiral ketone and the formation of a chiral alc...
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WO/2024/001593A1 |
Provided is an engineered ketoreductase polypeptide capable of preparing chiral alcohols, especially for catalyzing the reduction of ethyl 4-chloroacetoacetate to produce ethyl (R) -4-chloro-3-hydroxybutyrate. The polypeptides has high c...
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WO/2023/232225A1 |
The present invention relates to a method for the production of an L-glufosinate P-ester from the corresponding L-glufosinate P-ester carbamoylate, which is enzymatically catalyzed by a carbamoylase. The L-glufosinate P-ester and the L-g...
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WO/2023/198697A1 |
The present invention relates to a method for preparing α-branched β'-hydroxy carbonyl compounds through enzymatic-catalyzed reductive aldol reaction by reacting α,β-unsaturated carbonyl donors with carbonyl acceptors in the presence...
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WO/2023/197017A1 |
A method for preparing chiral amines useful as pharmaceutical intermediates is provided. The method comprises contacting an ester of formula I in which R1 is a methyl or an ethyl group; R2 is a linear or branched C1 – C4 alkyl group; a...
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WO/2023/185184A1 |
Provided are monoamine oxidase and an application thereof in a biocatalytic method.
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WO/2023/184791A1 |
Disclosed is a method for enzymatic synthesis of a brivaracetam chiral intermediate, i.e., a method for synthesizing a brivaracetam chiral intermediate (R)-3-cyanohexanoic acid by catalyzing the hydrolysis of 3-cyanohexanitrile using an ...
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WO/2023/088098A1 |
Provided are a dehydrogenase mutant L283V/L286V and a preparation method therefor and an application thereof. The amino acid sequence of the mutant L283V/L286V is as shown in SEQ ID NO: 1; or leucine at position 283 and position 286 of d...
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WO/2023/042081A1 |
The invention relates to a process to produce a (1r,4r)-4-substituted cyclohexane-1-amine [further referred as trans-4-substituted cyclohexane-1-amine] of formula (T), starting from a diastereomeric mixture of 4-substituted cyclohexane-1...
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WO/2023/029310A1 |
Provided is a synthesis method for L-glufosinate-ammonium, in the technical field of pesticide production. The synthesis method for L-glufosinate-ammonium comprises: using a hydantoin derivative as a raw material and water as a solvent, ...
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WO/2023/012819A1 |
The present invention provides recombinant transaminase polypeptides, fusion protein comprising the same and process of designing the same. Further, the present invention provides a process of preparing chiral amines catalyzed by the rec...
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WO/2023/278240A1 |
A process for producing optically active (R)-3-hydroxybutyrate and (R)-3-hydroxyvalerate mixtures, where the ratio between them is defined by the composition of PHB-co-HV, used as raw material for the production process, formulations con...
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WO/2022/259458A1 |
The present invention provides a method for producing an (S)-3-halogeno-2-methyl-1,2-propanediol by which the (S)-3-halogeno-2-methyl-1,2-propanediol having a high optical purity can be efficiently produced. The present invention perta...
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WO/2022/228506A1 |
Disclosed are a Glu/Leu/Phe/Val dehydrogenase mutant and an application thereof in the preparation of L-phosphinothricin. When the Glu/Leu/Phe/Val dehydrogenase mutant is aligned with the amino acid sequence of Glu/Leu/Phe/Val dehydrogen...
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WO/2022/226065A2 |
The present disclosure relates, at least in part, to the production of delta-lactones from fatty acid substrates via a batch fermentation method in an engineered microbe using a recombinant cytochrome P450 monooxygenase.
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WO/2022/226071A1 |
The present disclosure relates, at least in part, to the production of delta-lactones and gamma-lactones from fatty acid substrates (e.g., fatty acid substrates of C16-C25) via a batch fermentation method in an engineered microbe using a...
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WO/2022/207753A1 |
Methods for the production of L-glufosinate (also known as phosphinothricin or (S)-2- amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid) ammonium salt are provided. The methods comprise a refined multi-step process. The first step involv...
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WO/2022/171652A2 |
The present invention relates to a method of hydrolysing bicyclic monoterpenes with an α/β-hydrolase-fold esterase being a carboxyl esterase comprising or consisting of an amino acid sequence with at least 80% identity to SEQ ID No. 1 ...
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WO/2022/157768A1 |
A process for the formation of high-purity magnesium L-lactate crystals from homogenous and heterogenous decomposed organic waste is provided. The process provides magnesium L-lactate crystals with improved enantiomeric purity and overal...
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WO/2022/150596A1 |
The present invention relates to processes for preparing linkers that are useful in the conjugation of therapeutic molecules (e.g., cytotoxic agents) with targeting moieties (e.g., proteins, peptides, antibodies, nanoparticles, nucleic a...
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WO/2022/089572A1 |
The present disclosure relates to synthesis of enantiomerically rich key drug intermediates as a means for manufacturing of thiocarbamate derivatives as A2A adenosine receptor (A2AR) inhibitors. More particularly, the present disclosure ...
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WO/2022/079137A1 |
The present invention relates to formation of highly enriched (R)-pantolactone from conversion of keto-pantolactone in a bio-catalytic process using NADPH- dependent enzymes in the presence of NADH as co-factor.
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WO/2021/184883A9 |
Provided is a method for preparing L-glufosinate-ammonium by deracemization using a bio-enzyme, a mutant of glufosinate-ammonium dehydrogenase, and an application thereof. The method for preparing L-glufosinate-ammonium by deracemization...
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WO/2022/016597A1 |
A cyclohexanecarboxylate hydrolase, and a mutant, a coding gene, an expression vector, a recombinant bacterium, and an application thereof. The cyclohexanecarboxylate hydrolase AcEst1 and the mutant thereof have the function of preparing...
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WO/2021/254235A1 |
Disclosed is a method of preparing (S)-2-aminobutanamide by an enzymatic method, comprising using (R/S)-2-aminobutyrate as raw material, resolving same under the action of an ester hydrolase to obtain (S)-2-aminobutyrate, and further per...
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WO/2021/214278A2 |
The present invention relates to regioselective chemical and electrochemical processes for the preparation of an oxidized heterocyclic alpha-amino amide compounds. By applying specific catalysts or catalyst systems during chemical oxidat...
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WO/2021/214283A1 |
The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as furt...
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WO/2021/184557A1 |
Disclosed in the present invention is a method for preparing L-glufosinate-ammonium by means of asymmetric oxidization-reduction with a biological multienzyme coupling method. The method comprises: taking D,L-glufosinate-ammonium as a ra...
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WO/2021/182611A1 |
Provided is a technique that can further improve substrate specificity to an L-form during L-menthol and/or L-menthol ester production. A polypeptide that: has A120G, Q88A, Q88G, Q88D, Q88M, Q88L variants of a polypeptide comprising the ...
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WO/2021/165964A1 |
Industrial fermentation for the production of lactic acid from organic waste combined with chemical recycling of polylactic acid are provided, to obtain lactic acid at high yields.
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WO/2021/120134A1 |
Disclosed in the present invention is a fluoroacetate dehalogenase mutant, a sequence of the fluoroacetate dehalogenase mutant comprising a mutated sequence having an amino acid residue H at position 155 and/or an amino acid residue W at...
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WO/2021/115256A1 |
The present invention relates to a modified D-amino acid oxidase (DAAO). Specifically, the modified DAAO has activity of catalyzing glufosinate D to be oxidized to PPO. In addition, the modified DAAO has improved activity of catalyzing t...
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WO/2021/105742A1 |
The present invention relates to an improved process for the preparation of Pregabalin (I), which is simple, economical, efficient, and environment friendly, commercially viable with chemical and chiral purity at least 99.95%.
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WO/2021/047566A1 |
Disclosed are a preparation method for a compound as shown in formula (I) and levo-praziquantel. A racemate of ester of the compound of formula (I) is used as a substrate, and reaction is performed under the catalysis of immobilized lipa...
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WO/2020/255164A1 |
The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherei...
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WO/2020/224232A1 |
Provided are an Acinetobacter and the use thereof in the production of chiral 3-cyclohexene-1-formic acid. The taxonomic name of the Acinetobacter is Acinetobacter sp., and the Acinetobacter was deposited in the China General Microbiolog...
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WO/2020/216295A1 |
Provided is a method for resolving an optical isomer from a raceme by using supercritical fluid extraction technology. The method is mainly applied to the separation of a product obtained after enzymatic resolution. Taking a preparation ...
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WO/2020/218624A1 |
The present invention addresses the problem of providing a method for more easily and highly efficiently industrially producing high-purity L-cyclic amino acids from cyclic amino acids that have a double bond at the 1 position. According...
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WO/2020/214631A1 |
Methods for preparing crystalline L-glufosinate ammonium monohydrate are disclosed. The methods include forming a mixture comprising water, a water-miscible organic solvent, ammonium hydroxide, and a glufosinate starting material contain...
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WO/2020/208635A1 |
Systems and methods for processing organic waste, particularly mixed food waste, using a D-lactate oxidase are provided. The D-lactate oxidase eliminates D-lactic acid that is present in the organic waste. The processed organic waste can...
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WO/2020/196619A1 |
The present invention can produce an L-amino acid oxidase at a low cost and in a large quantity through a high expression of a recombinant protein, and the like, and provides a novel L-amino acid oxidase (ArtLAAO) having a wide substrate...
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WO/2020/183376A1 |
The present invention relates to an economical, enzyme catalyzed and commercially viable greener process for manufacturing Pregabalin of formula (I) in high yield with highchemical and chiral purity.
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WO/2020/173453A1 |
Disclosed is a method for resolving an optical isomer from a racemate by means of electrodialysis. Specifically, an electrodialysis technique is used in an enzymatic resolution process, mainly in the separation of products after enzymati...
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WO/2020/136236A1 |
The invention relates to a method and a device device for converting at least one reactant(5) into a reaction product and separating the at least one reactant from the reaction product, wherein the device comprises a vessel (10) with a v...
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WO/2020/119280A1 |
The present invention relates to the technical field of bioengineering and food, and relates to a method for enzymatic resolution of a chiral substance, comprising the following steps: (1) preparing an enzyme solution having a lipase con...
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WO/2020/107781A1 |
Disclosed is a novel method for preparing (S)-1,2,3,4-tetrahydroisoquinoline-3-formic acid by enzymatic resolution. Said method comprises: using racemic 1,2,3,4-tetrahydroisoquinoline-3-formic acid or a salt thereof as a substrate, using...
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