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WO/2024/026326A2 |
Methods for treating and/or prognosing breast cancer are provided. The method includes determining an Immunescore (IS) for gene sets selected from an immunological signature gene set, wherein the IS is based on an immunological model, de...
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WO/2024/023368A1 |
The invention relates to a method for the prediction of an increase of dipeptidyl peptidase 3 (DPP3) in a critically ill patient. In particular, the method comprises providing a sample from said patient, determining a level of Dipeptidyl...
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WO/2024/021748A1 |
A droplet preparation device and a method. A chip (3) and a temperature control module (6) are both arranged in a chamber (5); the temperature control module (6) is used for regulating the temperature value of the interior of the chip (3...
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WO/2024/026440A1 |
Provided herein are methods, compositions, kits and systems for the detection, identification and quantification of bacteria and fungi. In particular, provided herein are methods, compositions, kits and systems comprising oligonucleotide...
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WO/2024/026007A1 |
Provided herein are compositions and methodologies for identifying microbes in biofilms and adhered to biotic and abiotic surfaces, utilizing enzymes that degrade biofilms and disperse aggregated clusters of microorganisms. Utilizing enz...
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WO/2024/024427A1 |
The present disclosure provides a method for determining outer membrane detachment in a cyanobacterium that makes it possible to conveniently determine whether or not the outer membrane of the cyanobacterium has been detached from the ce...
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WO/2024/024895A1 |
The present invention provides a treatment agent for NK2 Homeobox 1 (NKX2-1)-negative lung adenocarcinomas that includes a Porcupine inhibitor as an active ingredient, an NKX2-1-negative lung adenocarcinoma organoid, and a screening meth...
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WO/2024/025923A1 |
The present disclosure provides methods for assessing responsiveness or non-responsiveness to a therapeutic agent (e.g., ICB therapy and/or anti-angiogenic) in subjects having a cancer or tumor based on angio-immune panel signatures. The...
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WO/2024/021686A1 |
An ultra-sensitive nanopore structure, a chip, an analysis device, an amino acid detection method, a protein detection method, and a use. The ultra-sensitive nanopore structure relates to a nanopore (8); the pore diameter of the nanopore...
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WO/2024/023523A1 |
The present invention relates to methods for extracting nucleic acids from a sample comprising one or more cells. The methods comprise steps of lysing and mechanically disrupting cells in order to provide optimum parallel extraction of b...
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WO/2024/025831A1 |
Methods and systems for detecting contaminated fragments in a biological sample for cancer classification are disclosed. The system identifies CpG-SNP contamination markers. The CpG-SNP contamination markers include at least one SNP that...
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WO/2024/026336A2 |
Methods and oligonucleotide reagents for genotyping Epstein-Barr virus are disclosed. In particular, genetic profiling is used to detect BALF2 variants in the genome of Epstein-Barr virus in an infected individual to predict the risk of ...
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WO/2024/023219A1 |
In an example of a method, a deoxyribonucleic acid sample is exposed to tagmentation in the presence of a tagmentation buffer including a divalent cation cofactor and a transposase enzyme to generate a tagmented DNA fragment complex. A c...
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WO/2024/026418A1 |
Provided are compositions and methods for prophylaxis or treatment of a disorder associated with type I interferon induced inflammation. The compositions involve use of an agent that inhibits the function and/or reduces the level of long...
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WO/2024/026275A1 |
Methods and systems for determining a loss of heterozygosity (LOH) status of the one or more HLA-T genes are described. The methods may comprise, for example: identifying, using one or more processors, a plurality of genomic segments in ...
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WO/2024/020909A1 |
Disclosed herein is directed to a lactate oxidase variant that exhibits reduced affinity to lactate as compared to a wild-type lactate oxidase. The lactate oxidase variant has one or more amino acid substitutions occurring at positions 9...
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WO/2024/026362A2 |
Provided herein are pseudoviruses expressing a SARS-CoV-2 S glycoprotein. Also provided herein are assays that employ the pseudoviruses to evaluate the immunogenicity of a biological sample against a SARS-CoV-2 virus or variant thereof. ...
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WO/2024/022738A1 |
The present invention is based, in part, on the definition of a plurality of panels of genes and/or fragments thereof (target sequences within the genes) as defined in the claims, which allow the accurate classifying of an endometrium be...
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WO/2024/026427A1 |
Methods and systems for species identification are disclosed. The methods and systems include: obtaining first, second, and third trained artificial intelligence (AI) models; obtaining one or more runtime images including a subject; dete...
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WO/2024/024646A1 |
The present invention provides an expression vector carrying a gene encoding LHFPL6 protein and a gene encoding TM7SF3 protein. The present invention also provides a vector set comprising an expression vector carrying a gene encoding LHF...
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WO/2024/025806A1 |
The presently described techniques relate generally to providing motion feedback (e.g., motion system calibration and/or sample alignment) in the context of an imaging system (such as a time delay and integration (TDI) based imaging syst...
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WO/2024/026509A2 |
The present disclosure provides methods for individualized selection of, and monitoring of treatment using a neurodegenerative therapeutic agent such as Sigma-1 receptor agonist therapy for a subject, based on changes in gene expression ...
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WO/2024/025481A1 |
Provided is a CRISPR RNA (crRNA) applicable in a CRISPR-based ribonucleoprotein (RNP) system for reacting towards one or more genetic materials derived from Burkholderia pseudomallei in a biological sample. The crRNA comprises a spacer r...
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WO/2024/025815A1 |
Described are methods and apparatuses for isolating and purifying mRNA using Immobilized Metal Affinity Chromatography (IMAC). The methods and apparatuses use IMAC matrices and IMAC conditions designed to selectively bind and elute mRNA,...
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WO/2024/026084A2 |
A method for storage of digital information via a biopolymer includes: receiving digital information; designing a target biopolymer sequence; encoding the digital information; synthesizing the target biopolymer sequence via a layered mic...
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WO/2024/023860A1 |
The present invention concerns a method for predicting the development of resistance to BRAF inhibiting drugs, alone or in combination with MEK inhibiting drugs (i.e. MAPK pathway inhibitors or simply MAPKi), in an anti-tumour treatment,...
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WO/2024/023510A1 |
The present invention provides methods for detecting and/or distinguishing one or more single nucleotide polymorphisms (SNPs) in a target nucleic acid sequence in a sample, the method comprising: providing a first oligonucleotide probe c...
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WO/2024/026360A2 |
Disclosed herein is an assay for measuring inhibition of binding between SARS-CoV-2 Spike (S) glycoproteins and hACE2. Also provided herein are methods of using the assay to evaluate the efficacy of COVID-19 vaccines.
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WO/2024/021172A1 |
Provided in the present invention are an SNP molecular marker associated with intramuscular fat traits in pigs and the use thereof, and a method and kit for detecting the molecular marker. The SNP molecular marker is a base at position 1...
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WO/2023/114915A9 |
The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifyi...
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WO/2024/026376A2 |
The present disclosure provides methods and systems for performing experiments and computational methods for generating, analyzing, and using multi-omics data and leveraging such multiomics data and computational analysis for application...
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WO/2024/025247A1 |
The present invention provides an analytic method to provide information needed for the diagnosis of patients with ovarian cancer resistant to cisplatin, which is an anticancer drug widely used in the treatment of ovarian cancer, the met...
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WO/2024/026364A2 |
The present disclosure provides a multiplexed fluorescence in situ hybridization method that enables single-cell and spatial analysis of gene expression in plant tissue in a transgene-free manner. The present disclosure provides methods ...
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WO/2024/025536A1 |
We used a powerful longitudinal within-subject design in individuals with psychiatric disorders to discover blood gene expression change between self-reported low anxiety and high anxiety states. We prioritized the list of candidate biom...
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WO/2024/022207A1 |
The methods and compositions disclosed herein relate to preparing libraries to sequence long molecules in their entirety using massively parallel short read sequencing. The methods disclosed herein generate a nested set of nucleic acid c...
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WO/2024/023944A1 |
A genetic testing device 1 further comprises a calculation unit 2d that adds, to the time at which an analyte is put, an available standby time depending on the priority of the analyte and calculates a target time by which dispensation t...
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WO/2024/026441A2 |
The invention provides methods and device for determining the identity and order of units of large biopolymers. Device of the invention use electrical fields to translocate the molecule through the channel and pass the molecule, base-by-...
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WO/2024/024147A1 |
Disclosed are: a method for identifying, by using refractive index distribution data of an observation object containing liver cells, bile canaliculus regions included in the observation object; and a method for evaluating the bile canal...
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WO/2024/026035A2 |
Provided herein are isolated peptides that bind to a phage that infects and lyses the pathogenic bacterium P. aeruginosa. The peptides are useful as in vivo tracers for the real-time analysis of phage therapy.
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WO/2024/026075A1 |
Methods and systems are disclosed for covariate prediction from methylation features. A system identifies a feature set of genomic regions by training one or more regressions to evaluate a covariance score of a genomic region. The system...
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WO/2024/019555A1 |
The present invention relates to a molecular biological composition, kit, and diagnostic method for diagnosing Alzheimer's disease dementia by measuring the methylation level of CpG sites in the promoter of the ATPase secretory pathway C...
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WO/2024/017155A1 |
Provided is a bubble-free lysis composition capable of rapidly lysing and releasing a nucleic acid of a virus and the like, wherein the lysis composition is acidic and does not contain a surfactant and a guanidine salt, and thus has almo...
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WO/2024/017510A1 |
The present invention relates to the field of in vitro methods for identifying a subject suitable for treatment with a combination of immunotherapy and chemotherapy by identifying a specific genetic signature in a biological sample from ...
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WO/2024/020122A1 |
The methods, compositions and kits described herein provide signal amplification approaches for the detection of target biomolecules that significantly increase the sensitivity of detection using target-binding ligand molecules. The meth...
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WO/2024/020543A2 |
The present disclosure features kits and methods for diagnosis and treatment of actinomycetia (e.g., corynebacteriales) infections, e.g., caused by mycobacterial cells. The methods include using a mixture of lytic enzymes to specifically...
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WO/2024/020441A1 |
The present disclosure provides improved breeding methods that allow for the selection of a member or members of a population having a desired phenotype using a limited number of genetic markers. In certain aspects, the methods for selec...
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WO/2024/020348A2 |
The present disclosure provides a device comprising a transducer with adjustable focus. In some examples, the device comprises an acoustic transducer configured to provide an acoustic beam. The device may further comprise a lens mount ac...
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WO/2024/020036A1 |
Methods and systems for segmenting sequencing regions obtained from a sample interval are disclosed, sample contamination detection are disclosed. In particular, an analytics system accesses test sequences from a sample. The test sequenc...
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WO/2024/018485A1 |
Methods and systems for detection and identification of pathogens and antibiotic resistant genes are disclosed herein. The method is a high throughput, rapid comprehensive method for identification of pathogens in a sample or subject. Th...
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WO/2023/158740A9 |
The present invention relates to systems and methods for well planning and management in a field to maximize the production of hydrocarbons. Specifically, the present invention involves identifying microbial compositions (including pheno...
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