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WO/2024/065665A1 |
The present invention provides a slide of a gene sequencing chip, a gene sequencing chip, a processing method for the slide of the gene sequencing chip, and a gene sequencing method. The slide of the gene sequencing chip comprises: a sub...
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WO/2024/073713A1 |
This disclosure relates to novel amplification compositions and methods, in particular for use in nucleic acid amplification and sequencing, preferably that do not involve reagents that are thermophilic.
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WO/2024/072805A1 |
Compositions and methods for diagnosis and evaluation of prognosis of epithelial ovarian cancer (EOC) are provided. Development of an artificial intelligence approach entitled MethylBert and its application to identification of methylati...
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WO/2024/072111A1 |
The present invention relates to a digital real-time PCR analysis method and aims to provide a digital real-time PCR method that enables digital real-time PCR analysis for samples across a wide concentration range, including both high an...
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WO/2024/071375A1 |
The present invention addresses the problem of providing: a human astrocyte cell mass that is induced and differentiated from an astrocyte progenitor cell derived from a human iPS cell; a method for producing the human astrocyte cell mas...
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WO/2024/072929A1 |
The present disclosure provides a method of assessing translation efficacy of an mRNA using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The mRNA is first translated into protein either in a cell lysate (cell-free translati...
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WO/2024/071530A1 |
The present invention relates to fluorescent nanodiamond coated with porous polydopamine, a method for preparing the fluorescent nanodiamond, and novel use of the fluorescent nanodiamond. The fluorescent nanodiamond coated with porous po...
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WO/2024/067674A1 |
Provided is a hydrogel-based sequencing method suitable for a flowcell sequencing system and also supporting open-source sequencing systems, and which can effectively reduce costs while ensuring sequencing efficiency and accuracy.
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WO/2024/069937A1 |
The present invention pertains to a reaction vessel for nucleic acid amplification, said reaction vessel having a vertically long shape, wherein a lower part in the lengthwise direction is a reaction liquid accommodation space and an upp...
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WO/2024/065069A1 |
The invention relates to a method for determining cellular identity from a biological sample in a matrix, which comprises providing a biological sample suspected of containing cells or microorganisms; carrying out an optional step of cel...
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WO/2024/066461A1 |
A method for identifying microorganisms having an oil reservoir flooding function based on metagenomics and metatranscriptomics, which comprises the following steps: S1, extracting the total DNA and total RNA from a water sample of an oi...
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WO/2024/073038A1 |
Liquid reservoirs, cartridge assemblies and related systems and methods are disclosed. An example implementation includes an apparatus that includes a body, a cover, and a lid assembly. The body includes a top surface and a storage chamb...
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WO/2024/064751A2 |
Provided is a method of determining whether a patient has bladder cancer, colon cancer, or breast cancer. Also provided is a method of determining whether a patient has a chronic inflammatory disease. Additionally provided is a method of...
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WO/2024/062341A1 |
A sterilization indicator reading apparatus is provided. The reading apparatus includes a housing including a top portion defining an aperture therethrough. The aperture is dimensioned to at least partially receive a sterilization indica...
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WO/2024/063119A1 |
The present invention achieves an image translation device, for example, that can effectively utilize an existing diagnostic imaging model. An image translation device (1) comprises an image translation unit (22) that includes a first ge...
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WO/2024/064866A2 |
The present disclosure provides methods of identifying treatment protocols for cancer patients using released tumor cells (RTCs). Method described herein include isolating/enriching RTCs, profiling RTCs and comparing RTCs to reference RT...
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WO/2024/063036A1 |
The present invention pertains to a method and a kit for detecting the methylation of target DNA. Specifically provided is a method for detecting the methylation of target DNA, the method comprising: a step in which adaptor DNA including...
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WO/2024/062445A1 |
A method for predicting disease incidence, progression, aggressiveness, and prognosis of brain tumors including gliomas and astrocytomas using palladin as a marker. Palladin expression is also disclosed as a therapeutic target for the tr...
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WO/2024/062239A1 |
The invention relates to methods for detecting and quantifying the presence of an organism in a sample, typically for detecting and quantifying the presence of a non-host organism in a host, and kits providing components useful for perfo...
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WO/2024/062641A1 |
An image sensor cover member (4) according to an embodiment comprises a pressing part (4A) that presses the surface of a liquid sample (S) placed in a sample placement space (1A) above an image sensor (11) included in an imaging device (...
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WO/2024/062237A1 |
There is described a method of spatially resolved cellular profiling for integrating profiling data of a cell or cell-derived material with spatial positioning of the cell or cell- derived material, the method comprising: contacting the ...
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WO/2024/062992A1 |
A DNA sequence screening method of the present invention comprises at least: (a) a step for preparing a plasmid that contains a plurality of DNA fragments encoding a multi-modular biosynthetic enzyme by accumulating DNA fragments using t...
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WO/2024/064193A1 |
Methods and compositions comprising primers and probes to detect nucleic acids are provided. The probes comprise a ribonucleotide that can be cleaved by an RNase H2 enzyme when the probe is annealed to a reverse complement of a universal...
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WO/2024/064112A2 |
Magnetic particles capture a biological target molecule for cryo-electron microscope imaging. The magnetic particles include paramagnetic beads. At least two spacer modules extend from a periphery of the paramagnetic beads comprising a f...
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WO/2024/064810A2 |
Provided herein are systems and methods for identifying collateral lethal genes via metabolic fluxes and the use of such genes for the identification of, selections of, and use of therapeutic agents. Further provided herein are identifie...
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WO/2024/061185A1 |
One aspect of the present invention relates to an RNAi (dsRNA) duplex reagent capable of inhibiting the expression of a target gene. The dsRNA duplex has a F-modified nucleotide at a specific position in an antisense strand or sense stra...
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WO/2024/064814A1 |
Disclosed herein are methods of determining whether a subject suffering from non-small cell lung cancer (NSCLC) is sensitive to treatment with osimertinib. In some embodiments, the method comprises obtaining an experimental matrix compri...
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WO/2024/064818A2 |
The disclosure provides compositions and methods for enzyme-mediated precise cell targeting.
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WO/2024/062126A1 |
The present invention provides a method for detecting a target nucleic acid molecule in a sample, using padlock probes and rolling circle amplification. The method herein provides a new way of removing free padlock probes which have fail...
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WO/2024/064136A1 |
Disclosed herein are methods, compositions, and kits for rapid molecular diagnostics that integrate sample processing (including sample inactivation, sample lysis, nucleases inhibition, nucleic acid extraction, nucleic acid stabilization...
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WO/2024/063653A1 |
This disclosure describes methods, compositions, kits, and uses for nucleic acid amplification and subsequent detection of the nucleic acid amplification product, using labeled nucleotides and a differently labeled probe or primer. In th...
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WO/2024/064673A2 |
Provided herein are compositions and methods that allow for the identification of specific cell types that are transduced by a barcoded adeno-associated virus (AAV). These compositions and methods can be used to identify the cellular tro...
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WO/2024/064761A2 |
Provided herein are methods for screening edited genomic sequences for their effect on expression of a target gene, and for designing a target sequence edit for introducing to a target sequence of a nucleic acid molecule. Also provided a...
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WO/2024/061799A1 |
The invention relates to deformable polymers comprising immobilised primers, particularly for use in nucleic acid sequencing, such as concurrent sequencing.
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WO/2024/060327A1 |
Provided is a tertiary lymphoid structure component marker for predicting the prognosis of nasopharyngeal cancer, which comprises one or more of a germinal center B cell component marker, a follicle-assisted CD4+ T cell component marker,...
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WO/2024/064675A1 |
Methods for determining a functional status of a variant are described. The methods may comprise, for example, receiving sequence read data associated with a plurality of samples; determining one or more feature attributes based on the s...
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WO/2024/061978A1 |
The invention relates to a method for the diagnosis of ulcerative colitis in a subject by detecting a nucleic acid target region and to oligonucleotides, oligonucleotide probes and kits to be used in this method.
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WO/2024/063449A1 |
The present invention relates to a curved plasmonic metal nanostructure based on biomolecules and a nanoplasmonic biosensor using same.
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WO/2024/063484A1 |
The present invention relates to a pharmaceutical composition containing Cbfβ (Core-binding factor subunit beta) expressing vascular smooth muscle cells or a culture fluid thereof as an active ingredient for the prevention or treatment ...
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WO/2024/063938A1 |
This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having prostate cancer. For example, methods and materials that can be used to determine whether or not a prostate cancer (e.g., a castra...
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WO/2024/060534A1 |
Provided is a method for regulating the number of maize tassel branches, comprising: constructing an miR529 overexpression vector with two tandem repeating hairpin structures by utilizing T-DNA insertion transgenic technology; transferri...
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WO/2024/062603A1 |
Provided is a point mutation rate detection method capable of conducting quantitative examination. The point mutation rate detection method according to the present invention is used for multiplex ligation-dependent probe amplification (...
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WO/2024/064679A1 |
Embodiments of the present disclosure provide systems and methods for determining a functional status of a genomic variant. For example, methods according to the present disclosure comprise receiving sequence read data for a plurality of...
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WO/2024/064962A2 |
The present disclosure relates to polymer beads comprising (i) biomarkers and (ii) nucleic acids comprising: (a) a primer binding site; and (b) a unique molecular identifier; wherein the nucleic acids are bound to the biomarker; and wher...
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WO/2024/064255A2 |
Disclosed are methods for identifying and treating a subject having obstructive sleep apnea.
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WO/2024/064913A1 |
The present disclosure provides gene therapy vectors, such as recombinant adeno-associated virus (rAAV) for expressing a human micro-dystrophin gene. The present disclosure also provides compositions and methods of using these rAAV to tr...
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WO/2023/234965A9 |
A method and system is for receiving data representing gene clusters, the gene clusters including one or more genes configured to encode one or more polypeptides or other small molecules; accessing a machine learning model, the machine l...
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WO/2024/064639A1 |
In some examples, novel nanogel particles are described having dual functionality, temperature responsiveness and pH responsiveness. For nucleic acid sequencing, amplification primers are grafted to nanogel particles to form primer-graft...
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WO/2024/061634A1 |
The invention relates to a method of predicting an outcome of a bladder cancer subject, comprising determining or receiving the result of a determination of a gene expression profile comprising gene expression levels, wherein the gene ex...
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WO/2024/059946A1 |
Multivalent trident aptamers comprising the general formula [A-SA]2 or 3-L-[SB-B] in which a central branched linker molecule (L) possesses 2 or 3 variable arms ([A-SA]2 or 3), and a root ([SB-B]), connected by a central carbon atom, to ...
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