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Matches 1 - 50 out of 184,923

Document Document Title
WO/2021/092496A1
Provided herein are thiazolidinedione analogues that are useful for treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), diabetes, and other metabolic inflammation-mediated disease and disorders. Furt...  
WO/2021/089819A1
The invention relates to the use of an iron-score based on the expression level of at least 2 genes, in particular at least 5, preferably at least 10, and even preferably 11 genes selected in the group consisting of ALAS1, HIF1A, LRP2, H...  
WO/2021/092323A1
A method of transferring material using a picking pin having a distal tip includes: forming a first coating of organic molecules on at least a portion of the distal tip of the picking pin; dipping at least a portion of the coated distal ...  
WO/2021/091927A1
Disclosed herein include systems, methods, and compositions for determining perturbations in single cells or performing integrated measurements using, for example, plasmids each comprising (i) a perturbation gRNA with a guide region targ...  
WO/2021/088317A1
Provided are an miRNA marker for the diagnosis and/or treatment of Alzheimer's disease. The miRNA marker is an miRNA-23 cluster. Also provided are the use of the microRNA of the miRNA-23 cluster in the diagnosis and/or treatment of Alzhe...  
WO/2021/092265A1
The disclosure features non-invasive methods for diagnosing non-alcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), and liver fibrosis in a subject by, e.g., determining the level of one or more lipids, glycans, hormones,...  
WO/2021/091611A1
Provided herein are methods for preparing biological samples for spatial proteomic analysis, methods of determining a location of a protein analyte in a biological sample, and methods of determining a location of a protein analyte and a ...  
WO/2021/092431A1
Provided herein are engineered DNA polymerases comprising modifications improving accuracy and processivity of the polymerase including modifications in the Motif A region, optionally, along with additional modifications in the palm and/...  
WO/2021/092226A1
Described herein, in certain embodiments, are methods of determining an outcome of at least one embryo following transfer of the embryo to a recipient female, where the outcome is based on the expression of at least one gene in an endome...  
WO/2021/089606A1
The invention relates to an in vitro method for isolating nucleic acids associated to or contained inside extracellular vesicles (EVs) from a sample based on the formation of a DMB-EVs precipitate and the isolation of the nucleic acids p...  
WO/2021/087586A1
The present invention relates to a novel transgenic corn event expressing a truncated or modified form of the insecticidal protein Cry1Da designated event ME240913. The invention relates to the unique nucleic acids for the event ME240913...  
WO/2021/090877A1
This brain organoid, which has a phosphorylated 3-repeat tau protein and a phosphorylated 4-repeat tau protein, can be produced by a brain organoid production method including a step 1 for performing floating culture on human pluripotent...  
WO/2021/092436A1
Methods and processes to identify neoplastic tissue antigens derived from alternative splicing (AS) are described, in accordance with various embodiments of the invention. Also described are novel tumor antigens that are useful as target...  
WO/2021/092220A1
The disclosure provides a method of treating a tumor in a human subject in need thereof, comprising administering an effective amount of a checkpoint inhibitor to the subject, wherein the subject is identified as having a parenchymal inf...  
WO/2021/092236A1
Methods and systems for deconvoluting tumor ecosystems for personalized cancer therapy are disclosed. Generally, human cancers exhibit large variation in behavior between and within patients, which is in large part related to cellular co...  
WO/2021/088306A1
Provided are a method for testing the drug sensitivity of a pathogenic microorganism. The method comprises: obtaining biomarker information of a sample to be tested; determining the location of said sample in a phylogenetic tree accordin...  
WO/2021/092386A1
Disclosed herein include systems, methods, compositions, and kits for labeling nucleic acid targets in a sample. In some embodiments, nucleic acid targets (e.g., mRNAs) are initially barcoded on the 3' end and are subsequently barcoded o...  
WO/2021/091803A1
The disclosure relates a kit and a method for detecting an IDH mutation. The kit includes primers, polymerase, and especially a series of properly-designed probe sequences specific for the IDH mutation detection. Moreover, the method use...  
WO/2021/092476A1
Processes and materials to detect cancer from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences derived from a neoplasm. Detection of somatic va...  
WO/2021/091513A1
The invention is related to natural origin rapid diagnostic test of Methicillin Resistant Staphylococcus aureus (MRSA).  
WO/2021/091211A1
The present invention relates to a method for obtaining a whole genome sequence for determining a MERS corona virus infection, and a use thereof. A method, a kit and a composition of the present invention comprise 14 universal primer set...  
WO/2021/091239A1
The present invention relates to a method for providing information for colorectal cancer diagnosis, a composition for diagnosing colorectal cancer, and a kit comprising same, and, more particularly, to: a method for providing informatio...  
WO/2021/092331A1
Disclosed are methods relating to the use of circular PCMTD1 as a diagnostic and prognostic marker for leukemias and cancers with a p53 mutation and/or BCR/ABL fusions. Additionally, disclosed herein are oligonucleotides and antibodies t...  
WO/2021/092166A1
Methods of treating subjects having G4C2 dipeptide repeat expansion in the gene C90RF72, including subjects having amyotrophic lateral sclerosis or frontotemporal degeneration (ALS/FTD), are provided. Compounds directed at reducing the t...  
WO/2021/088199A1
A specific nucleic acid fragment nano fluorescence trace rapid detection method based on CRISPR-Cas12g: take a specific nucleic acid fragment in a biological sample as a research object, and prepare a nucleic acid target of the biologica...  
WO/2021/091747A1
The invention relates to (i) an angiogenesis gene signature and (ii) a monocytic myeloid-derived suppressor cell (mMDSC) gene signature that are each predictive of patient response to treatment with a PD-1 antagonist, wherein the angioge...  
WO/2021/089559A1
The present disclosure relates to a method of treating kidney injury, by administering an anti-IL- 33 therapeutic agent which inhibits both ST2 signaling and RAGE signaling.  
WO/2021/092456A1
Provided herein are method of analyzing genomic and metabolomic data from fungi to identify relationships between biosynthetic gene clusters and mass spectrometric features of metabolites.  
WO/2021/092519A1
The present disclosure provides systems that include a CRISPR-associated (Cas) enzyme with trans cleavage activity; a guide CRISPR RNA (crRNA) including a guide sequence and a polynucleotide extension sequence, wherein the guide sequence...  
WO/2020/095052A8
A system for characterising a target polynucleotide, the system comprising a membrane and a pore complex; wherein the pore complex comprises: (i) a nanopore located in the membrane, and (ii) an auxiliary protein or peptide attached to th...  
WO/2021/088189A1
Disclosed is a method for homogenizing concentrations of different oligonucleotides in an oligonucleotide library and amplifying the oligonucleotide library at room temperature. The method can be used for DNA data storage. The method can...  
WO/2021/091487A1
The present invention relates to methods for determining the presence or amount of one or more target nucleic acid molecules in a sample by loop mediated isothermal amplification (LAMP) and probe detection, the method comprising (a) comb...  
WO/2021/087614A1
Microfluidic devices, systems and methods are described herein. More particularly, the microfluidic devices comprise a first layer including a plurality of electrodes, a second layer disposed on top of the first layer, the second layer i...  
WO/2021/092244A1
Provided are synthetic strands for nucleic acid sequencing. In some embodiments, the strands include a plurality of rotatable solid supports. The plurality of rotatable solid supports comprises solid supports each comprising on its surfa...  
WO/2021/092066A1
The disclosure provides methods for estimating tumor purity from tumor samples without use of matched-normal controls. A set of genomic regions are identified based on a nucleic acid sequence data that is aligned to a reference genome. E...  
WO/2021/091009A1
The present application discloses a method for screening an inflammatory bowel disease therapeutic agent on the basis of a mechanism in which RORα inhibits NF-κB transcriptional activity in the bowels, thereby inhibiting the expression...  
WO/2021/092231A1
Techniques for a user interface for pathogen analysis are provided. The user interface may include an interactive dendrogram that identifies a plurality of biological samples and their corresponding sequences. The biological samples of t...  
WO/2021/067941A3
The present disclosure provides, inter alia, compositions, methods, and kits for improving the success rate of in vitro fertilization in small ruminants using microbiome profiles. According to some aspects, the present disclosure provide...  
WO/2021/091868A1
The present disclosure provides rodent models of increased bone mineral density and/or bone mineral content, genetically modified rodents and isolated rodent cells or tissues having a disruption of one or both alleles of the Zinc and Rin...  
WO/2021/092070A1
Methods for somatic variant calling from an unmatched biological samples is provided. The method can include obtaining nucleic acid sequence data corresponding to a biological sample of a subject. The method can also include aligning the...  
WO/2021/092224A1
Disclosed herein, are systems and methods for analyzing complex data signals using artificial intelligence and/or deconvolution algorithms to determine output pertaining to the state or status of one or more parameters. Data sets may inc...  
WO/2021/092299A1
Systems, primers, kits, and methods for detecting microsatellite instability in a biological sample are described. Signal data is received from a capillary electrophoresis genetic analysis instrument, wherein the signal data is measured ...  
WO/2021/092433A2
Methods for enhancing specificity of an analyte binding moiety or probe oligonucleotide to an analyte are provided herein. For example, methods provided herein include blocking a capture binding domain, thereby preventing hybridization t...  
WO/2021/092523A1
Systems and methods for detecting microsatellite instability in a biological sample are described. Signal data is received from a capillary electrophoresis genetic analysis instrument, wherein the signal data is measured from fluorescenc...  
WO/2021/090910A1
A molecular structure altering agent which interacts specifically with protein aggregates and detects said protein aggregates, and a detection method of protein aggregates are provided. Further, a cleaning agent and a cleaning method are...  
WO/2021/087890A1
A method for building a personalized probiotics database, and the use thereof in the screening of probiotics. The method comprises co-culturing probiotics and a biological sample, then analyzing a secretion volume of IL-10, a secretion v...  
WO/2021/087613A1
A three-dimensional (3D) cell culture system comprising: a solid porous polymeric support, preferably comprising a biocompatible polymer; a first type of cells bound to the solid porous polymeric support; and a biocompatible hydrogel com...  
WO/2021/087615A1
There is described herein, a method of capturing and analyzing cell-free methylated DNA in a sample. The method involves subjecting the sample to library preparation to permit subsequent sequencing of the cell-free methylated DNA. A pred...  
WO/2021/092221A1
The disclosure provides a method of treating a tumor in a human subject in need thereof, comprising administering an effective amount of a checkpoint inhibitor to the subject, wherein the subject meets at least two of the following condi...  
WO/2021/089821A1
The invention relates to the use of an iron-score based on the expression level of at least 1 gene, in particular at least 3, preferably at least 5, and even preferably 8 genes selected in the group consisting of APEX1, TFRC, HIF1A, ABCG...  

Matches 1 - 50 out of 184,923