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WO/2023/083083A1 |
A gateless ion mobility spectrometer and an ion mobility spectrometry-time-of-flight mass spectrometer, relating to the technical field of analytical instruments. The gateless ion mobility spectrometer comprises an ion source (1), a samp...
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WO/2023/083082A1 |
The present invention belongs to the technical field of analytical instruments, and specifically relates to a photoionization ion source having a compact structure, and a photoionization time-of-flight mass spectrometer. The photoionizat...
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WO/2023/084868A1 |
This mass spectrometer comprises: a plasma ion source that ionizes a sample with plasma; a mass spectrometry unit that performs mass spectrometry on the ionized sample; and a sampling cone. The mass spectrometer also comprises a skimmer ...
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WO/2023/079761A1 |
This mass spectrometer comprises a mass filter, a detection unit, a cancellation circuit, and a power source device. The mass filter selects ions having a mass-to-charge ratio corresponding to an applied AC voltage. The detection unit ha...
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WO/2023/079526A2 |
Ion optical elements in accordance with various aspects of the present teachings can, in various embodiments, be utilized to replace conventional stacked-ring ion optical elements (e.g., ion guides, ion tunnels, ion funnels, reflectrons)...
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WO/2023/076583A1 |
A method of performing automatic ion control for mass spectrometry includes acquiring, by charge detection mass spectrometry, a mass spectrum comprising a plurality of peaks representing intensity as a function of mass-to-charge ratio (m...
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WO/2023/073586A1 |
Disclosed are methods for detecting and quantifying target analytes in a sample by mass analysis that include detecting the presence of ions of the target analyte in the sample and quantifying the amount of the target analyte. The method...
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WO/2023/076662A1 |
An apparatus for facilitating quantitative anatomic pathology using mass spectrometry imaging includes a solid support having at least one flat surface, a tissue homogenate having a thickness mounted to the at least one flat surface of t...
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WO/2023/073983A1 |
This mass spectrometer 10 that introduces ions generated in an ionization chamber 16 into a vacuum chamber 18 and detects those ions with a detector 34 comprises a connecting tube 26, a connection body 40, a sampling cone 50, a fixing me...
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WO/2023/073587A1 |
The presently claimed and described technology provides a sample processing system comprising at least one sample introduction device, wherein the at least one sample introduction device is configured to receive a sample; a mass analyzer...
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WO/2023/072366A1 |
A method of processing data determined from an image-charge/current signal representative of ions of a given charge state (Q) undergoing oscillatory motion of a respective oscillation frequency (ω) within an ion analyser apparatus. The ...
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WO/2023/074480A1 |
A gas analysis device (1) comprises: a sample chamber (12) into which flows a sample gas (9) to be measured, the sample chamber being provided with a dielectric wall body structure; a plasma generation mechanism (13) that generates a pla...
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WO/2023/076602A1 |
A method, mass spectrometer and computer readable medium for acquiring mass spectral data; comprising acquiring mass spectral data for a sample in a profile mode; computing spectral loadings from the acquired mass spectral data; operatin...
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WO/2023/067658A1 |
This mass spectrometry device comprises a mass filter, a wave detection unit, and a power source device. The mass filter selects ions having a mass-to-charge ratio that corresponds to an applied AC voltage. The wave detection unit detect...
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WO/2023/067447A1 |
Methods and systems for performing differential mobility spectrometry-MS/MS are provided herein. In various aspects, methods and systems described herein can determine corresponding MS data from differential mobility spectrometry-MS/MS d...
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WO/2023/066804A1 |
The invention relates to a method for detecting a spectrum (10) of an ion species, comprising the steps of a) capturing a subset of ions comprising the ion species in an ion trap, b) thermalizing the ions captured in the ion trap by mean...
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WO/2023/069290A1 |
Provided herein are designs of a linear time-of-flight (TOF) mass spectrometer that achieves a high mass resolving power to ions independently having a mass-to-charge (m/z) ratio between 1,000 and 100,000. The TOF mass spectrometer compr...
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WO/2023/069608A1 |
Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol pa...
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WO/2023/061832A1 |
A sample introduction system (10) for a spectrometer, comprising: ‐ a sample inlet (11) for receiving a sample to be nebulized, ‐ a nebulizer (20) for nebulizing the sample, ‐ a gas inlet (12) for receiving gas for transporting the...
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WO/2023/062896A1 |
Provided is a method for performing mass spectrometry in which precursor ions from sample components and radicals are made to react in a reaction chamber 132, thereby generating product ions from the precursor ions, the method including:...
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WO/2023/057933A1 |
A mount assembly for holding a microchannel plate in an ion detector includes an input side clamping plate including a plurality of input side pads; and an output side clamping plate including a plurality of output side pads, wherein, wh...
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WO/2023/057449A1 |
The invention relates to an apparatus for accommodating and for analysing, in a spatially and depth-resolved manner, a solid sample material, the apparatus comprising a substantially gas-tight sealed housing (1) with a sample-accommodati...
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WO/2023/060225A1 |
A sampling device is disclosed, including a substrate, a reservoir surface disposed on at least a portion of the substrate and configured to retain a liquid, the reservoir surface having a reservoir surface area and being formed of a res...
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WO/2023/057881A1 |
Systems and methods are provided for processing in real-time and using Gaussian fitting digitized signals from ions detection in time-of-flight (TOP) mass spectrometry. Acquisition/analog-to- digital conversion may be applied in the cour...
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WO/2023/058248A1 |
This mass analysis device comprises: a vacuum container; a detector; a buffer material; a pressing member; and a compression-amount restricting mechanism. The vacuum container is used for mass analysis of a sample. The detector, buffer m...
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WO/2023/057744A1 |
An ion detector for a mass and/or ion mobility spectrometer is disclosed. The ion detector comprises a dynode arranged and configured such that primary ions to be detected by the ion detector impact upon the dynode and generate first ele...
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WO/2023/057927A1 |
A method of performing targeted multiplexed mass spectrometry includes performing, at a mass spectrometer, a targeted MS3 analysis of an isobaric tag-labeled target analyte included in a multiplex sample eluting from a column. The target...
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WO/2023/059645A1 |
A drop-in multi-optics module for a quantum-particle (e.g., rubidium, cesium) cell provides for more convenient and cost-effective manufacture of such cells (including vacuum cells, cold/ultra-cold matter cells, vapor cells, and channel ...
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WO/2023/053624A1 |
A support unit according to the present invention comprises a first support body and a second support body. The first support body has an ionization substrate. The second support body is arranged to face the first support body. The secon...
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WO/2023/053296A1 |
This mass spectrometer comprises: a quadrupole mass filter including first, second, third, and fourth rod electrodes; a first voltage application unit that applies first high-frequency alternating-current voltage to the first and second ...
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WO/2023/052966A1 |
In one aspect, a method for fragmenting ions in a mass spectrometer is disclosed, which includes introducing a plurality of precursor ions into a collision cell of a mass spectrometer, generating a potential barrier in the collision cell...
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WO/2023/053041A1 |
In one aspect, a mass spectrometer is disclosed, which includes an ion path along which an ion beam can propagate, and an ion beam deflector positioned in the ion path and configured to modulate transfer of an ion beam received from an u...
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WO/2023/053583A1 |
A sample support according to one embodiment of the present invention is provided with: a support substrate having a support face; a sheet-shaped adhesion layer provided on the support face; an ionization substrate that is provided on th...
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WO/2023/047267A1 |
A method for performing mass spectrometry (MS) comprises receiving MS data corresponding to a plurality of MS runs, wherein MS data corresponding to an MS run of the plurality of MS runs comprises detected intensities for a plurality of ...
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WO/2023/048958A1 |
A method of milling a sample that includes a first layer formed over a second layer, where the first and second layers are different materials, the method comprising: milling the region of the sample by scanning a focused ion beam over t...
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WO/2023/047302A1 |
In one aspect, a method of operating a mass spectrometer is disclosed, which comprises ionizing a sample to generate a plurality of ions, and introducing at least a portion of the ions into an inlet orifice of the mass spectrometer. At l...
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WO/2023/049276A1 |
Aspects of the subject application include applying a spatial barcode to a cellular sample and then performing suspension mass cytometry on the cellular sample. For example, a sample barcode comprising a known distribution of sample barc...
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WO/2023/046837A1 |
An analytical system (100, 100') comprising a mass spectrometer (60) and an ionization source (61) coupled to the mass spectrometer (60) is herein disclosed. The analytical system (100, 100') further comprises an analytical fluidic syste...
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WO/2023/048903A1 |
Aspects of the present disclosure include circuits, systems and methods for baseline signal restoration over differential outputs. Circuits according to certain embodiments include an input module for receiving a signal from a sensor, an...
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WO/2023/047366A1 |
A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality ...
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WO/2023/047546A1 |
This mass spectrometer is provided with: an ionization part which has a nozzle for spraying a sample liquid and an ionization electrode and which ionizes a compound in the sample liquid by an atmospheric pressure ionization method; a hea...
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WO/2023/048611A1 |
A charged particle spectrometer (100) is described, which comprises an imaging energy analyser (101) and an electrostatic lens system (102), having a first deflector (16A/16C, 16B/16D) and optionally a second deflector (17A/17C, 17B/17D)...
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WO/2023/046716A1 |
The present invention relates to a composition comprising (i) cesium iodide, (ii) ethylamine and/or formic acid, and (iii) methanol and/or water. The present invention further relates to a method for calibrating a mass spectrometry (MS) ...
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WO/2023/047304A1 |
Methods and system that determines disulfide and trisulfide linkages within analytes (e.g., polypeptides) is described. In certain aspects, a sample comprising polypeptides (such as an antibody) may be subjected to dissociation using an ...
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WO/2023/044582A1 |
Rapid calibration of a quantitative analysis instrument such as a mass spectrometer is performed using a calibration chip surface having different sized surface energy traps (SETs) and a transfer chip surface having same sized SETs, wher...
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WO/2023/042369A1 |
Provided is a mass spectroscopy device 1 comprising: a probe 111 which sprays a liquid sample; an electrical discharge electrode 112 which is disposed at a position where the liquid sample is sprayed from the probe 111; an electrical dis...
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WO/2023/044036A1 |
The present invention generally pertains to methods of characterizing at least one protein of interest in a biological sample. In particular, the present invention pertains to the use of automated iterative tandem mass spectrometry (AIMS...
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WO/2023/042348A1 |
This mass spectrometry device comprises an ionizing unit which has an ionizing electrode and which ionizes a compound in a sample solution by means of atmospheric pressure ionization, a high-voltage power source for applying a voltage to...
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WO/2023/041937A1 |
An ion source assembly comprising: a target plate for holding a sample to be analysed; a laser for ionising the sample on the target plate so as to form analyte ions; one or more optical elements; an ion guide for guiding the analyte ion...
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WO/2023/037313A1 |
Methods and systems for adjusting instrument setting, improving fidelity of isotope pattern for mass spectra, and/or determining molecular mass with improved accuracy are disclosed. In one example, a method for determining Mmono of a com...
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