Login| Sign Up| Help| Contact|

Patent Searching and Data

Document Type and Number:
Japanese Patent JP2000500479
Kind Code:
PCT No. PCT/FR96/01847 Sec. 371 Date May 19, 1998 Sec. 102(e) Date May 19, 1998 PCT Filed Nov. 21, 1996 PCT Pub. No. WO97/19063 PCT Pub. Date May 29, 1997Compounds of formula (I), wherein R1 is fluorine, hydroxy, (C1-5) alkoxy, (C1-5) alkylthio, hydroxy(C1-5)alkoxy, a -NR10R11, group, cyano, (C1-5) alkyl-sulphonyl or (C1-5) alkylsulphinyl; R2 and R3 are each (C,4) alkyl or, taken together with the nitrogen atom to which they are attached, form a saturated or unsaturated 5- to 10-membered heterocyclic radical optionally substituted one or more times by (C1-3) alkyl or (C1-3) alkoxy; each of R4, R5, R6, R7, R8 and R9 is independently hydrogen, halogen or trifluoromethyl, and when R1 is fluorine, R4, R5, R6, R7, R8 and/or R9 may also be fluoromethyl; with the proviso that at least one of substituents R4 or R7. is other than hydrogen; each of R10 and R11 is independently hydrogen or (C1-5) alkyl, or R10 and R11, taken together with the nitrogen atom to which they are attached, form a heterocyclic radical selected from pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazin-1-yl optionally substituted by (C1-4) alkyl; a method for preparing same, and pharmaceutical compositions containing said compounds, are disclosed. Said compounds have very high affinity for central cannabinoid receptors.

Baltic, francis
Congie, christian
Martinez, Serge
Rinaldi, Muriel
Application Number:
Publication Date:
January 18, 2000
Filing Date:
November 21, 1996
Export Citation:
Click for automatic bibliography generation   Help
International Classes:
A61K31/00; A61K31/415; A61K31/445; A61K31/4453; A61P25/00; A61P43/00; C07D231/14; (IPC1-7): C07D231/14; A61P25/00; A61P43/00; A61K31/415; A61K31/4453
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)