Title:
【発明の名称】9-デオキソ-9a-アザ-9a-ホモエリスロマイシンAのハロ誘導体
Document Type and Number:
Japanese Patent JP2002543213
Kind Code:
A
Abstract:
The invention relates to halo derivatives of 9a-N-(N'-arylcarbamoyl)- and 9a-N-(N'-arylthiocarbamoyl)-9-deoxo-9a-aza-9a-homoerythromycin A of the general formula (I)wherein R has the meaning of a substituted aryl group of the formula (II)wherein substituents a, b, c, d and e are the same or different and at least one of them has the meaning of halo, a (C1-C6)haloalkyl or a (C1-C6)haloalkoxy group, whereas the remaining ones have the meaning of hydrogen, halo, a (C1-C6)alkyl or a (C1-C6)alkoxy group, and X has the meaning of oxygen or sulfur, and pharmaceutically acceptable addition salts thereof with inorganic or organic acids, to a process for their preparation, to a process for the preparation of pharmaceutical compositions comprising them and to the use of these pharmaceutical compositions for the treatment or prevention of bacterial infections.
Inventors:
Marsic-Issuq, Duolika
Kyundu Zuik, Nedejelko
Gabriella, Kobleher
Mutaku, Stepan
Marsic, Natasa
Kyundu Zuik, Nedejelko
Gabriella, Kobleher
Mutaku, Stepan
Marsic, Natasa
Application Number:
JP2000615632A
Publication Date:
December 17, 2002
Filing Date:
May 02, 2000
Export Citation:
Assignee:
Privat Alma Seu Tosca Industria Deionitzko
International Classes:
A61K31/70; A61K31/7048; A61P31/04; C07H1/00; C07H17/08; A61K; A61P; C07H; (IPC1-7): C07H17/08; A61K31/7048; A61P31/04
Domestic Patent References:
| JPH07252292A | 1995-10-03 | |||
| JPH07252292A | 1995-10-03 |
Attorney, Agent or Firm:
Shigeru Yagita (2 outside)