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Title:
【発明の名称】分子間で会合した化合物とこれらの化合物を含む凝集体
Document Type and Number:
Japanese Patent JP2003503465
Kind Code:
A
Abstract:
Compound of the general formula (I) X(B)m (I) wherein X is an m-valent unit and B are identical or different and denote K-R, wherein K is a bond or is A1-(A2-A3)k-sp, wherein A1 is (CH2)tY(CH2)u, wherein Y is >C-O, >NH, -O-, -S- or a bond, t is an integer from 0 to 6 and u is an integer from 0 to 6, A2 is -NHCO-, -CONH-, -OCONH- or SCONH-, or is -CO-, A3 is (CH2)r, O(CH2)r, NH(CH2)r, S(CH2)r or -(CHQ)-, wherein r is an integer from 1 to 6 and Q is a substituted or unsubstituted alkyl or aryl group, sp is a divalent spacer or a bond, and k is an integer from 5 to 100, and R is hydrogen; a ligand suitable for specific bonding to a receptor; a marker molecule; or a catalytically active group; and m is at least 2, with the proviso that (1) in the compound at least one R is not hydrogen, (2) there are at least two K that are not a bond, and (3) X, B and m are so selected that an intermolecular association of the K in liquid phase by the formation of hydrogen bonds is possible, with formation of aggregates that present on the surface a plurality of R that are not hydrogen, and (4) the molar mass of the fragment X(K)m is less than 20,000.

Inventors:
ボフィン、ニコライ ウラディミロフィッチ
トゥシコフ、アレクサンドル ボリソフィッチ
キナレフ、アレクサンドル アレクサンドロフィッチ
ディクサル、マリヤ アレクサンドロフナ
ガムバリヤン、アレクサンドラ セルギーフナ
マリニナ、ファレンティナ ペトロフナ
Application Number:
JP2001507508A
Publication Date:
January 28, 2003
Filing Date:
June 30, 2000
Export Citation:
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Assignee:
シンテサム ゲゼルシャフト フュル メディツィニッシェ バイオヘミー エムベーハー
International Classes:
A61K31/7008; A61K39/395; A61K47/42; A61K47/48; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/00; A61P43/00; C07H13/04; C07H15/04; C07H15/18; C07K5/00; C07K7/06; C07K9/00; G01N33/531; (IPC1-7): C07H15/18; A61K31/7008; A61K39/395; A61K47/42; A61K47/48; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/00; A61P43/00; C07H15/04; C07K5/00; C07K7/06
Foreign References:
WO1998014215A21998-04-09
WO1998014215A21998-04-09
Other References:
JPN5002012318, REUTER J D, BIOCONJUGATE CHEMISTRY, 19990301, V10 N2, P271−278, US
JPN5002012319, ZANINI D, JOURNAL OF ORGANIC CHEMISTRY, 19961018, V61 N21, P7348−7354, US
JPN6011002608, VIROLOGY, 1997, vol.232, pp.345−350
JPN5002012322, REUTER J D, AMERICAN SOCIETY FOR MICROBIOLOGY, 1998, V98 NA−77, P51, US
JPN6011002611, Carbohydrate Research, 1998, vol.305, pp.443−461
Attorney, Agent or Firm:
浅村 皓 (外3名)