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Title:
【発明の名称】光学的に純粋なテトラヒドロプテリンおよびその誘導体、特に光学的に純粋なテトラヒドロ葉酸およびその誘導体を立体特異的水素化によって製造する方法
Document Type and Number:
Japanese Patent JP2003504370
Kind Code:
A
Abstract:
Process for the preparation of tetrahydropterin and tetrahydropterin derivatives by hydrogenating pterin and pterin derivatives with hydrogen in the presence of a hydrogenating catalyst, in which the hydrogenation is carried out in a polar reaction medium and metal complexes that are soluble in the reaction medium are employed as the hydrogenation catalysts. The process is suited to the hydrogenation, particularly asymmetric hydrogenation, of folic acid, folic acid salts, folic acid esters, folic acid ester salts or dihydroforms thereof, with the proviso that in the event of using folic acid, carboxylic acid salts thereof or dihydroforms thereof the reaction medium is aqueous, and in the event of using folic acid esters, folic acid ester salts or dihydroforms thereof the reaction medium is an alcohol. The process opens up straightforward access to achiral and chiral pterin derivatives.

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Inventors:
ミュラー・ハンス・ルドルフ
モーゼル・ルドルフ
グレーン・ビオラ
プギン・ベノイト
Application Number:
JP2001509729A
Publication Date:
February 04, 2003
Filing Date:
July 12, 2000
Export Citation:
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Assignee:
エプロバ・アクチエンゲゼルシヤフト
International Classes:
A61P7/06; B01J31/24; C07D475/04; C07F9/50; C07F17/02; (IPC1-7): C07D475/04; A61P7/06; B01J31/24; C07F9/50; C07F17/02
Domestic Patent References:
JPH069635A1994-01-18
JPH04312586A1992-11-04
JPS61100583A1986-05-19
JPS60178887A1985-09-12
JPS5959697A1984-04-05
Foreign References:
WO1998001457A11998-01-15
Attorney, Agent or Firm:
江崎 光史 (外3名)