Title:
【発明の名称】テトラヒドロ葉酸エステル塩およびテトラヒドロ葉酸の純粋異性体をテトラヒドロ葉酸エステル塩の分別結晶化によって製造する方法
Document Type and Number:
Japanese Patent JP2003504371
Kind Code:
A
Abstract:
A process for preparing and concentrating (6S,alphaS) or (6S,alphaR) tetrahydrofolic acid ester salts and (6S,alphaS) or (6S,alphaR) tetrahydrofolic acid, characterized by preparing or dissolving equimolar or concentrated mixtures of diastereomers of addition salts of tetrahydrofolic acid esters with aromatic sulphonic acids in organic solvents, followed by crystallizing them at least once, and then if applicable hydrolyzing the crystallizate to produce (6S,alphaS) or (6S,alphaR) tetrahydrofolic acid, crystallizing the latter as a free acid or isolating it in the form of a salt.
Inventors:
Muller Hans Rudolph
Mosel Rudolph
Grain viola
Mosel Rudolph
Grain viola
Application Number:
JP2001509730A
Publication Date:
February 04, 2003
Filing Date:
July 12, 2000
Export Citation:
Assignee:
Eproba Actien Gezershyaft
International Classes:
C07B61/00; C07D475/04; (IPC1-7): C07D475/04
Domestic Patent References:
| JPS497416A | 1974-01-23 | |||
| JPH04312586A | 1992-11-04 | |||
| JPH0841062A | 1996-02-13 | |||
| JPH07145168A | 1995-06-06 |
Attorney, Agent or Firm:
Mitsufumi Ezaki (3 others)