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Title:
【発明の名称】酵素によって触媒される治療活性化
Document Type and Number:
Japanese Patent JP2003505466
Kind Code:
A
Abstract:
This invention provides novel substrate compounds that selectively inhibit the proliferation of pathological cells, for example, pathological cells that endogenously overexpress a target enzyme that confers resistance to biologic and chemotherapeutic agents. The enzyme acts on a substrate compound to 1) convert it to a cellular toxin and/or 2) release a toxic byproduct. In one embodiment, the activity of the target enzyme has been greatly enhanced in a target cell as a result of loss of tumor suppressor function and/or selection resulting from previous exposure to chemotherapy. In another embodiment, the pathological cell contains a target enzyme that is an expression product of an infectious agent in the cell. Further provided by this invention is a method for treating a subject by delivering to the subject a prodrug as described herein. The prodrugs of this invention may be used alone or in combination with other chemotherapeutics or alternative anti-cancer therapies such as radiation.

Inventors:
シェパード, エイチ. マイケル
チャン, ミン ファイ
グロージアック, マイケル ピー.
Application Number:
JP2001512538A
Publication Date:
February 12, 2003
Filing Date:
July 21, 2000
Export Citation:
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Assignee:
ニューバイオティックス インコーポレイテッド
International Classes:
C12Q1/02; A61K31/7068; A61K31/7072; A61K47/48; A61P35/00; A61P43/00; C07F9/6512; C07H19/06; C07H19/073; C07H19/10; C07H19/23; C12Q1/527; (IPC1-7): C07H19/10; A61K31/7068; A61K31/7072; A61P35/00; A61P43/00; C07H19/073; C07H19/23; C12Q1/02; C12Q1/527
Foreign References:
WO1999008110A11999-02-18
WO1999023104A21999-05-14
WO1999037753A11999-07-29
WO1999008110A11999-02-18
WO1999023104A21999-05-14
WO1999037753A11999-07-29
Attorney, Agent or Firm:
山本 秀策