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Title:
【発明の名称】感光性保護基を有するヌクレオシド誘導体
Document Type and Number:
Japanese Patent JP2003513101
Kind Code:
A
Abstract:
The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I), where R1=H, F, Cl, Br, I, NO2; R2=H, CN, where R1 and R2 are not simultaneously H; R3=H, 1-4 C alkyl, phenyl; R4=H or a conventional functional group for the synthesis of oligonucleotides; R5=H, OH, halogen or XR6, where X=O or S and R6=a conventional nucleotide protecting group; B=adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl or 5-amino-4-imidazolcarboxamid-3-yl, where, if B=adenine, cytosine or guanine the primary amine functionality, optionally, carries a permanent protecting group. Furthermore, these derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

Inventors:
Pfreiderer, Wolfgang
Buehler, Ziggrit
Gierich, Heiner
Application Number:
JP2001535372A
Publication Date:
April 08, 2003
Filing Date:
October 10, 2000
Export Citation:
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Assignee:
Nig Chemie Game Behr
International Classes:
C07H19/067; C07H19/06; C07H19/073; C07H19/10; C07H19/16; C07H19/167; C07H19/173; C07H19/20; C07H21/00; (IPC1-7): C07H19/067; C07H19/073; C07H19/167; C07H19/173
Attorney, Agent or Firm:
Tadahiko Ito (2 outside)