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Patent Searching and Data

Document Type and Number:
Japanese Patent JP2003526405
Kind Code:
A method for enhanced Photodynamic Therapy (PDT) treatments by applying dendrimer-photosensitizer complexes to bring multiple photosensitizer moieties to a treatment site is provided. The most benefit is derived for treatments using systemic introduction of the photosensitizer formulation. Photosensitizers are covalently coupled to the peripheral bonding places of dendrimers, using labile bonds which are breakable in preference over bonding within either photosensitizer or dendrimer, and the photosensitizers are separated from the complexes in one or more successive cycles. Tetrapyrroles are the photosensitizers employed. In one embodiment the complex is also bound to an antibody or antibody fragment, which aids in targeting the complex to a desired treatment site. After introduction into a patient, the photosensitizers are controllably released, at the treatment site, from the complexes by either light, chemical, or a combined light/chemical effect. Generally the photosensitizers develop their full photodynamic activity as free molecules after being released from the complex. More than one type of photosensitizer may be bound in the complexes. Release and/or activation may be done in a single step or with repeated steps.

Application Number:
Publication Date:
September 09, 2003
Filing Date:
July 28, 2000
Export Citation:
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バイオリテック アーゲー
バイオリテック インコーポレーテッド
International Classes:
A61K47/30; A61K31/409; A61K41/00; A61K47/42; A61K47/48; A61N5/06; A61P17/00; A61P17/06; A61P31/12; A61P31/22; A61P35/00; (IPC1-7): A61N5/06; A61K31/409; A61K47/30; A61K47/42; A61K47/48; A61P17/00; A61P17/06; A61P31/12; A61P31/22; A61P35/00
Foreign References:
Attorney, Agent or Firm:
斉藤 武彦 (外1名)