Title:
【発明の名称】フェニルプロパノールアミンの経皮投与
Document Type and Number:
Japanese Patent JP2003528045
Kind Code:
A
Abstract:
Methods and systems are provided for the transdermal administration of racemic phenylpropanolamine, i.e., a mixture of two or more of the four isomers of phenylpropanolamine, (+)-norephedrine, (-)-norephedrine, (+)-norpseudoephedrine, and (-)-norpseudoephedrine. Generally, the racemate will be a mixture of (+)-norephedrine and (-)-norephedrine. The racemic drug is administered along with a permeation enhancer. The permeation enhancer is preferably a basic compound, and optimally is a hydroxide-releasing agent such as sodium hydroxide.
Inventors:
Sea, Song-Min
Macy, Russell
Luo, Eric C.
Macy, Russell
Luo, Eric C.
Application Number:
JP2001544673A
Publication Date:
September 24, 2003
Filing Date:
December 15, 2000
Export Citation:
Assignee:
Dermatren's, Incorporated
International Classes:
A61K9/06; A61K9/08; A61K9/107; A61K9/70; A61K31/137; A61K47/02; A61K47/30; A61K47/46; A61P9/00; A61P11/02; (IPC1-7): A61K31/137; A61K9/06; A61K9/08; A61K9/107; A61K9/70; A61K47/02; A61K47/30; A61K47/46
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)