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Title:
【発明の名称】ウイルスを用いた新生物の処置
Document Type and Number:
Japanese Patent JP2003530301
Kind Code:
A
Abstract:
The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.

Inventors:
Roberts, Michael S.
Lawrence, Robert M.
Groen, William S.
Sandler, Abbey
Bon Beauster, Raid W.
Application Number:
JP2000611872A
Publication Date:
October 14, 2003
Filing Date:
April 17, 2000
Export Citation:
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Assignee:
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services
International Classes:
A61K31/282; A61K31/573; A61K35/76; A61K38/00; A61K38/19; A61K38/20; A61K38/21; A61P35/00; A61P35/02; A61K45/00; A61P35/04; A61P43/00; C07J5/00; C07K16/24; C12N7/02; G01N33/50; A61K39/00; (IPC1-7): A61K35/76; A61K31/282; A61K31/573; A61K38/00; A61K45/00; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07J5/00
Domestic Patent References:
JPH09503995A1997-04-22
JPH105342A1998-01-13
JPS6360941A1988-03-17
Foreign References:
WO1997045550A21997-12-04
WO1999008692A11999-02-25
Other References:
CSATARY,L.K. ET AL: "Attenuated veterinary virus vaccine for the treatment of cancer", CANCER DETECT PREV, vol. 17, no. 6, JPN7010002330, 1993, pages 619 - 627, XP008037652, ISSN: 0001690200
LORENCE,R.M. ET AL: "Complete regression of human fibrosarcoma xenografts after local Newcastle disease virus therapy", CANCER RES, vol. 54, no. 23, JPN6010043479, 1994, pages 6017 - 6021, XP008037689, ISSN: 0001690201
LORENCE,R.M. ET AL: "Newcastle disease virus as an antineoplastic agent: induction of tumor necrosis factor-alpha and aug", J NATL CANCER INST, vol. 80, no. 16, JPN7010002331, 1988, pages 1305 - 1312, XP008037656, ISSN: 0001690202, DOI: 10.1093/jnci/80.16.1305
CANCER RESEARCH, vol. 50, JPN6009054124, 1990, pages 2261 - 2267, ISSN: 0001690203
Attorney, Agent or Firm:
Shusaku Yamamoto