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Patent Searching and Data


Title:
キラル2-および3-置換カルボン酸類の動力学的分割
Document Type and Number:
Japanese Patent JP2004505098
Kind Code:
A
Abstract:
One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomeric mixture of a chiral substrate, e.g., a cyclic carbonate or cyclic carbamate; and a nucleophile, e.g., an alcohol, amine or thiol. A preferred embodiment of the present invention relates to a method for achieving the kinetic resolution of racemic and diastereomeric mixtures of derivatives of α- and β-amino, hydroxy, and thio carboxylic acids. In certain embodiments, the methods of the present invention achieve dynamic kinetic resolution of a racemic or diastereomeric mixture of a substrate, i.e., a kinetic resolution wherein the yield of the resolved enantiomer or diastereomer, respectively, exceeds the amount present in the original mixture due to the in situ equilibration of the enantiomers or diastereomers under the reaction conditions prior to the resolution step.

Inventors:
デン,リ
ハン,ジャンフェン
タン,リャン
Application Number:
JP2002516229A
Publication Date:
February 19, 2004
Filing Date:
July 31, 2001
Export Citation:
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Assignee:
ブランデイス ユニヴァーシティー
International Classes:
C07B53/00; C07B57/00; C07B61/00; C07C51/00; C07C51/487; C07C67/00; C07C67/12; C07C69/732; C07C227/34; C07C269/00; C07C269/06; C07C271/22; C07D233/86; C07D263/20; C07D263/44; C07D317/36; C07D333/24; C07D401/14; C07D413/06; C07D453/02; (IPC1-7): C07C67/00; C07B53/00; C07C69/732; C07C269/00; C07C271/22; C07D263/44; C07D317/36; C07D333/24; C07D413/06
Attorney, Agent or Firm:
柳田 征史
佐久間 剛