Title:
アルファ,ベータ-不飽和ケトンの合成法
Document Type and Number:
Japanese Patent JP2004505100
Kind Code:
A
Abstract:
A method for the synthesis of an alpha,beta-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low temperature. The synthesis is used in a process for making substituted 1,4-dihydropyridines wherein a vinylogous amide is prepared by reacting a 1,3-cyclohexanedione with a phenylethylamine. The alpha,beta-unsaturated ketone can be reacted with a vinylogous amide to form a 1,5-diketone which can be converted to a substituted 1,4-dihydropyridine.
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Inventors:
Ian Patel
Philip Hopes
Philip Hopes
Application Number:
JP2002516236A
Publication Date:
February 19, 2004
Filing Date:
July 31, 2001
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07C209/22; C07C45/74; C07C211/40; C07C225/20; C07C253/30; C07C255/56; C07C255/58; C07C255/59; (IPC1-7): C07C209/22; C07C211/40; C07C253/30; C07C255/56; C07C255/58
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Hiroshi Sugimoto
Kosuke Nishimura
Hiroshi Sugimoto