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Patent Searching and Data


Title:
システインプロテアーゼの可逆的阻害剤として有用なスピロヘテロ環ニトリル類
Document Type and Number:
Japanese Patent JP2004508356
Kind Code:
A
Abstract:
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.

Inventors:
Beckali Jannes
Hicky Eugene Earl
Liu Weimin
Patel Usha Earl
Spero Dennis M
Sansan Shin
Thomson David S
Ward Yansei Dee
Young Eric Earl Earl
Application Number:
JP2002525107A
Publication Date:
March 18, 2004
Filing Date:
March 14, 2001
Export Citation:
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Assignee:
Boehringer Ingelheim Pharmaceuticals, Inc.
International Classes:
A61K31/40; A61K31/4468; A61K31/454; A61K31/496; A61K31/506; A61K31/517; A61K31/5365; A61K31/5377; A61K31/538; A61K31/541; A61K31/55; A61P1/04; A61P3/10; A61P9/10; A61P11/06; A61P19/10; A61P21/04; A61P25/28; A61P29/00; A61P31/00; A61P37/00; A61P37/06; C07D205/04; C07D207/14; C07D207/16; C07D211/58; C07D211/60; C07D211/66; C07D309/14; C07D335/02; C07D401/04; C07D401/12; C07D403/06; C07D405/12; C07D413/12; C07D413/14; C07D417/12; C07D455/02; C07D487/08; (IPC1-7): C07D207/16; A61K31/40; A61K31/4468; A61K31/454; A61K31/496; A61K31/506; A61K31/517; A61K31/5365; A61K31/5377; A61K31/538; A61K31/541; A61K31/55; A61P1/04; A61P3/10; A61P21/04; A61P25/28; A61P29/00; A61P31/00; A61P37/00; A61P37/06; C07D211/66; C07D401/12; C07D405/12; C07D413/12; C07D413/14; C07D417/12; C07D487/08
Foreign References:
WO2001019816A12001-03-22
US5776718A1998-07-07
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Toshio Imajo
Nobuo Ogawa
Murasha Atsuo
Takayoshi Nishijima
Atsushi Hakoda