Title:
ボロン酸化合物製剤
Document Type and Number:
Japanese Patent JP2004517932
Kind Code:
A
Abstract:
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of formula (1) in which Z 1 and Z 2 are moieties derived from sugar. The invention also provides methods for preparing such compounds. Lyophilizing a mixture comprising a boronic acid compound and a moiety derived from sugar produces a stable composition that readily releases the boronic acid compound upon reconstitution in aqueous media.
Inventors:
Plamondon, Lewis
Gournier, Lewis
Adams, Julian
Gupta, Shanker, Lal
Gournier, Lewis
Adams, Julian
Gupta, Shanker, Lal
Application Number:
JP2002559433A
Publication Date:
June 17, 2004
Filing Date:
January 25, 2002
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
THE UNITED STATES OF AMERICA
THE UNITED STATES OF AMERICA
International Classes:
A61K9/19; A61K31/69; A61K38/14; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P43/00; C07F5/02; C07F5/04; C07F5/05; C07H9/00; C07K5/06; C07K5/062; C07K5/065; C07K5/078; C07K5/08; C07K5/083; C07K5/097; C07K5/117; C07K7/02; C07K9/00; A61K38/00; (IPC1-7): C07F5/04; A61K9/19; A61K31/69; A61P29/00; A61P31/18; A61P35/00; A61P37/02; A61P43/00; C07F5/05; C07K5/062; C07K5/078; C07K5/083; C07K5/097; C07K5/117
Attorney, Agent or Firm:
Takashima Ichi