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Title:
抗菌及び細胞増殖抑制活性を有する炭水化物ベースの二環式環構造の製造及び使用
Document Type and Number:
Japanese Patent JP2005509615
Kind Code:
A
Abstract:
A compound of the formula : wherein R 1 is -H, -SPh, -Ph, -allyl or -benzyl; R 2 is -H, -Et, -allyl, -Me or -benzyl; R 3 is -H, -Et, -Me, -allyl or -benzyl; and R 4 and R 5 are both -OH or R 4 and R 5 together form a ring and are -OCH(Ph)O- ; or a pharmaceutically active derivative thereof. Pharmaceutical compositions comprising the above compounds and their use in therapy are also provided.

Inventors:
サス,ベネディクト
バン・デール・エイッケン,ヨハン
バン・ヘメル,ヨハン
ブロン,ペトラ
バンデンケルコホブ,ジャン
ルッテンス,バート
Application Number:
JP2003535711A
Publication Date:
April 14, 2005
Filing Date:
October 15, 2002
Export Citation:
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Assignee:
ケミン・ファーマ・ヨーロッパ
International Classes:
C07H15/203; A61K31/351; A61K31/357; A61K31/395; A61K31/7034; A61K31/7048; A61K31/7052; A61P31/04; A61P31/10; A61P31/12; A61P33/02; A61P35/00; A61P43/00; C07D309/10; C07D493/04; C07D493/14; C07D498/04; C07H9/00; C07H9/04; C07H13/12; (IPC1-7): C07D309/10; A61K31/351; A61K31/357; A61K31/395; A61K31/7034; A61K31/7048; A61K31/7052; A61P31/04; A61P31/10; A61P31/12; A61P33/02; A61P35/00; C07D493/04; C07D493/14; C07D498/04; C07H15/203
Domestic Patent References:
JPH05271160A1993-10-19
JPH07238080A1995-09-12
JPH0881490A1996-03-26
JPH08501071A1996-02-06
JP2000507246A2000-06-13
JP2000500807A2000-01-25
JPH06279295A1994-10-04
Foreign References:
WO2001038338A12001-05-31
Other References:
JPN6009043003, CRICH, D., et al., J. Am. Chem. Soc., 123(37), pp.9015−9020 (2001)
JPN6009043005, PETITOU, M., et al., Chem. Eur. J., 7(4), pp.858−873 (2001)
JPN6009043007, YU, B., et al., Tetrahedron Lett., 39(27), pp.4871−4874 (1998)
JPN6009043011, LIPTAK, A., et al., Acta Chim. Acad. Sci. Hung., 99(2), pp.201−208 (1979)
JPN6009043012, TANAKA, T., et al., Chem. Pharm. Bull., 41(7), pp.1232−1237 (1993)
Attorney, Agent or Firm:
社本 一夫
増井 忠弐
小林 泰
千葉 昭男
富田 博行
泉谷 玲子