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Title:
非ヌクレオシド逆転写酵素インヒビター
Document Type and Number:
Japanese Patent JP2005526851
Kind Code:
A
Abstract:
Compounds represented by formula I:whereinR<2 >is selected from the group consisting of H, (C1-4)alkyl, halo, haloalkyl, OH, (C1-6)alkoxy, NH(C1-4alkyl) or N(C1-4alkyl)2; R<4 >is H or Me; R<5 >is H or Me; R<11 >is H, (C1-4)alkyl, (C3-4)cycloalkyl and (C1-4)alkyl-(C3-4)cycloalkyl; A is a connecting chain of (C1-3)alkyl; B is O or S; n is 0 or 1; wherein when n is 0:Ring C is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted;and E is CONR<12>R<13>; CONHNR<14>R<15>; NR<16>COR<17>; NR<18>SO2(C1-6)alkyl; SO2NR<19>R<20>; or SO2R<21>; orwhen n is 1: Ring C is as defined above and E is a single bond or a connecting group; andRing D is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted with from 1 to 5 substituents;or a salt or a prodrug thereof are provided as inhibitors of HIV reverse transcriptase.

Inventors:
シモノー ブルーノ
ランドリ セルジュ
マレンファント エリック
ノード ジュリー
オメーラ ジェフリー
サヴォネカム ブーンカム
ヨアキム クリスティアン
Application Number:
JP2004505376A
Publication Date:
September 08, 2005
Filing Date:
May 14, 2003
Export Citation:
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Assignee:
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
International Classes:
A61K31/551; A61P31/18; A61P43/00; C07D471/14; (IPC1-7): C07D471/14; A61K31/551; A61P31/18; A61P43/00
Attorney, Agent or Firm:
熊倉 禎男
小川 信夫
箱田 篤
浅井 賢治
平山 孝二