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Title:
フェニルシクロヘキシルプロパノールアミン誘導体、その製造法、およびその治療的適用
Document Type and Number:
Japanese Patent JP2005530809
Kind Code:
A
Abstract:
The invention relates to compounds of general formula (I): where R1 represents H or a (C1-C4)alkyl, -CO(C1-C4)alkyl, (C1-C4)alkylphenyl or -CO-phenyl group, said phenyl optionally being substituted; R2 represents H, a halogen atom, an -S(O)z(C1-C4)alkyl group, where z is equal to 0, 1 or 2, an -NHSO2(C1-C4)alkyl group, an -NHSO2-phenyl group or an -NHSO2-(C1-C4)alkylphenyl group, said phenyl optionally being substituted; R3 represents an -X-R4 group-in which X represents a bond, an oxygen atom or a -CH2- group and R4 represents H or a -CR5R6-COOR7 group, where R5, R6 and R7 independently represent H or a (C1-C4)alkyl group-a phenyl group optionally substituted or fused with a dioxolane group, a -CO-NR8R9 group-where R8 represents H, a (C1-C4)alkyl group or a (C1-C4)alkyl(C1-C4)alkoxy group and R9 represents a (C1-C4)alkyl(C1-C4)alkoxy group, a -(CH2)n-A group, where n is equal to 0, 1, 2, 3 or 4 and where A represents an indolyl group, a fluorenyl group or a phenyl group which is substituted, an optionally substituted -NH-phenyl group or a -CH(R10)-(CH2)n-COOR11 group, where n is 0, 1, 2 or 3 and where R11 represents H or a (C1-C4)alkyl group and R10 represents H, a (C1-C4)alkyl group or a -CH2-phenyl group, said phenyl optionally being substituted, or a -COOR12 group, where R12 represents H or a (C1-C4)alkyl group; their process of preparation and their therapeutic application.

Inventors:
Bovi, philip, el
Setch, Robert
Kuroshi, Chiziano
Ovenier, Venier
Application Number:
JP2004507430A
Publication Date:
October 13, 2005
Filing Date:
May 26, 2003
Export Citation:
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Assignee:
Sanofi-Aventis
International Classes:
C07D317/58; A61K31/138; A61K31/18; A61K31/195; A61K31/198; A61K31/216; A61K31/235; A61K31/36; A61K31/4045; A61P1/00; A61P1/04; A61P1/14; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P13/10; A61P15/00; A61P15/06; A61P17/02; A61P25/18; A61P25/24; A61P27/06; A61P43/00; C07C69/78; C07C211/35; C07C311/08; C07C317/22; C07D209/16; C07D263/56; (IPC1-7): C07C311/08; A61K31/18; A61K31/195; A61K31/198; A61K31/216; A61K31/36; A61K31/4045; A61P1/04; A61P1/14; A61P3/04; A61P3/06; A61P3/10; A61P13/10; A61P15/00; A61P15/06; A61P25/18; A61P25/24; A61P27/06; A61P43/00; C07C317/22; C07D209/16; C07D317/58
Attorney, Agent or Firm:
Shintaro Nogawa