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Title:
ポリケチド、及び他の天然物の製造
Document Type and Number:
Japanese Patent JP2005532809
Kind Code:
A
Abstract:
The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the efficient transformation of strains that produce FKBP analogues and recombinant cells in which cloned genes or gene cassettes are expressed to generate novel compounds such as polyketide (especially rapamycin) FKBP-ligand analogues, and to processes for their preparation, and to means employed therein (e.g. nucleic acids, vectors, gene cassettes and genetically modified strains).

Inventors:
アラン マチュウ グレゴリー
サビネ ガイセル
フルボジェ ペトコビック
スティーブン モッス
Application Number:
JP2004520912A
Publication Date:
November 04, 2005
Filing Date:
July 16, 2003
Export Citation:
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Assignee:
バイオチカ テクノロジー リミテッド
International Classes:
C12N15/09; A61K31/407; A61K31/436; A61K31/706; A61P31/10; A61P35/00; A61P37/04; C07D493/18; C07D498/18; C07H15/04; C07K14/36; C12N1/21; C12N15/10; C12N15/52; C12N15/70; C12N15/76; C12P17/18; C12P19/62; C12R1/55; (IPC1-7): C12N15/09; A61K31/407; A61K31/436; A61K31/706; A61P31/10; A61P35/00; A61P37/04; C07D498/18; C07H15/04; C12N1/21; C12P17/18
Domestic Patent References:
JP2010075187A2010-04-08
Attorney, Agent or Firm:
石川 徹