Title:
アシルアミノ-置換複素芳香族化合物および医薬としてのそれらの使用
Document Type and Number:
Japanese Patent JP2005538123
Kind Code:
A
Abstract:
The present invention relates to acylamino-substituted heteroaromatic compounds of the formula I, in which R<1>, R<2>, R<3>, R<4> and R<5> and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmaceutically active compounds which are useful in the treatment of various disease states including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency. They upregulate the expression of the enzyme endothelial nitric oxide (NO) synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
Inventors:
Hartmut Straubel
Pauls Wohlfalt
Peter Bellow
Pauls Wohlfalt
Peter Bellow
Application Number:
JP2004526764A
Publication Date:
December 15, 2005
Filing Date:
July 24, 2003
Export Citation:
Assignee:
Aventis Pharma Deutsche Land Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/4184; A61K31/422; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/497; A61K31/5377; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/28; A61P27/02; A61P43/00; C07D215/38; C07D235/30; C07D263/58; C07D277/82; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D409/12; C07D413/12; C07D417/12; C07D417/14; (IPC1-7): C07D235/30; A61K31/4184; A61K31/422; A61K31/427; A61K31/428; A61K31/433; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/497; A61K31/5377; A61P1/16; A61P3/10; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P13/12; A61P15/10; A61P19/10; A61P25/28; A61P27/02; A61P43/00; C07D277/82; C07D401/12; C07D401/14; C07D403/12; C07D409/12; C07D413/12; C07D417/12; C07D417/14
Foreign References:
| WO2001083427A1 | 2001-11-08 | |||
| WO2002034711A1 | 2002-05-02 | |||
| WO2000027819A2 | 2000-05-18 |
Other References:
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Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa