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Patent Searching and Data


Title:
テトラヒドロキノリン誘導体及びFSH受容体モジュレーターとしてのその使用
Document Type and Number:
Japanese Patent JP2006512346
Kind Code:
A
Abstract:
The present invention relates to tetrahydroquinoline derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are H, Me; R3 is (2-6C)heterocycloalkyl(1-4C)alkyl, (2-5C)heteroaryl(1-4C)alkyl, (6C)aryl (1-4C)alkyl, (1-4C)(di)alkylaminocarbonylamino(2-4C)alkyl, (2-6C) heterocycloalkylcarbonylamino(2-4C)alkyl, R5-(2-4C)alkyl or R5-carbonyl(1-4C)alkyl; R4 is (2-5C)heteroaryl, (6C)aryl, (3-8C)cycloalkyl, (2-6C)heterocycloalkyl or (1-6C) alkyl and R5 is (di)(1-4C)alkylamino, (1-4C)alkoxy, amino, hydroxy, (6C)arylamino, (di)(3-4C)alkenylamino, (2-5C)heteroaryl(1-4C)alkylamino, (6C)aryl(1-4C) alkylamino, (di)[(1-4C)alkoxy(2-4C)alkyl]amino, (di)[(1-4C)alkylamino(2-4C) alkyl]amino, (di)[amino(2-4C)alkyl]amino or (di)[hydroxy(2-4C)alkyl]amino. The present invention also relates to pharmaceutical compositions comprising said derivatives and the use of these derivatives to regulate fertility.

Inventors:
テイメルス,コウネリス・マリウス
カルステンス,ウイレム・フレデリク・ヨハン
Application Number:
JP2004561498A
Publication Date:
April 13, 2006
Filing Date:
December 16, 2003
Export Citation:
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Assignee:
アクゾ・ノベル・エヌ・ベー
International Classes:
C07D215/38; A61K31/47; A61K31/4709; A61K31/496; A61K31/5377; A61K31/55; A61P5/08; A61P15/08; A61P15/18; A61P35/00; C07D401/12; C07D405/12; C07D409/12
Domestic Patent References:
JP2002522433A2002-07-23
JPH10510840A1998-10-20
JP2004535456A2004-11-25
Foreign References:
US6200963B12001-03-13
Attorney, Agent or Firm:
川口 義雄
小野 誠
大崎 勝真
坪倉 道明