Title:
ABT-751による持続投与レジメン
Document Type and Number:
Japanese Patent JP2007500240
Kind Code:
A
Abstract:
The invention relates to pharmaceutical compositions comprising combinations of ABT-751 and anti-cancer drugs. These combinations have additive antitumorigenesis activity. This invention also relates to methods of treatment using the combinations.
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Inventors:
Gordon, Geary
Hajii, Ann Yi
Rosenberg, Saul H
Hajii, Ann Yi
Rosenberg, Saul H
Application Number:
JP2006533503A
Publication Date:
January 11, 2007
Filing Date:
June 01, 2004
Export Citation:
Assignee:
ABBOTT LABORATORIES
International Classes:
A61K45/00; A61K31/00; A61K31/44; A61K31/635; A61P35/00; A61P43/00
Other References:
JPN6010029033, ＹＡＭＡＭＯＴＯ， Ｋ．， ｅｔ ａｌ．, "Ｐｈａｓｅ Ｉ ｓｔｕｄｙ ｏｆ Ｅ７０１０", Ｃａｎｃｅｒ Ｃｈｅｍｏｔｈｅｒａｐｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ, 199807, Ｖｏｌ．４２， Ｎｏ．２, ｐ．１２７−１３４
JPN5006016140, ＨＡＮＤＥ， Ｋ．， ｅｔ ａｌ．, "Ａ Ｐｈａｓｅ Ｉ ｔｒｉａｌ ｏｆ ＡＢＴ−７５１， ａ ｎｏｖｅｌ ｍｉｃｒｏｔｕｂｌｉｎ Ｉｎｈｉｂｉｔｏｒ", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, 200211, Ｖｏｌ．３８, ｐ．Ｓ４２, GB, ＰＥＲＧＡＭＯＮ ＰＲＥＳＳ
JPN6010029038, ＫＯＹＡＮＡＧＩ， Ｎ．， ｅｔ ａｌ．, "Ｉｎ Ｖｉｖｏ Ｔｕｍｏｒ Ｇｒｏｗｔｈ Ｉｎｈｉｂｉｔｉｏｎ Ｐｒｏｄｕｃｅｄ ｂｙ ａ Ｎｏｖｅｌ Ｓｕｌｆｏｎａｍｉｄｅ， Ｅ７０１０， ａｇａｉｎｓｔ Ｒｏｄｅｎｔ ａｎｄ Ｈｕｍａｎ Ｔｕｍ", ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 19940401, Ｖｏｌ．５４， Ｎｏ．７, ｐ．１７０２−１７０６
JPN6010029041, ＦＵＮＡＨＡＳＨＩ， Ｙ．， ｅｔ ａｌ．, "Ｅｆｆｅｃｔ ｏｆ Ｅ７０１０ ｏｎ ｌｉｖｅｒ ｍｅｔａｓｔａｓｉｓ ａｎｄ ｌｉｆｅ ｓｐａｎ ｏｆ ｓｙｎｇｅｎｅｉｃ Ｃ５７ＢＬ／６ ｍｉｃｅ ｂｅａｒｉｎｇ ｏｒｔｈｏｔｏｐｉｃａｌｌｙ ｔ", Ｃａｎｅｒ Ｃｈｅｍｏｔｈｅｒａｐｙ ａｎｄ Ｐｈａｒｍａｃｏｌｇｙ, 200102, Ｖｏｌ．４７， Ｎｏ．２, ｐ．１７９−１８４
JPN6010029048, ＨＡＹＡＫＡＷＡ， Ｋ．， ｅｔ ａｌ．, "ＣＯＬＬＡＢＯＲＡＴＩＶＥ ＷＯＲＫ ＴＯ ＥＶＡＬＵＡＴＥ ＴＯＸＩＣＩＴＹ ＯＮ ＭＡＬＥ ＲＥＰＲＯＤＵＣＴＩＶＥ ＯＲＧＡＮＳ ＢＹ ＲＥＰＥＡＴＥＤ ＤＯＳＥ ＳＴＵＤＩＥＳ ＩＮ ＲＡＴＳ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ, 2000, Ｖｏｌ．２５， Ｓｐｅｃｉａｌ Ｉｓｓｕｅ, ｐ．１７３−１７８
JPN5006016140, ＨＡＮＤＥ， Ｋ．， ｅｔ ａｌ．, "Ａ Ｐｈａｓｅ Ｉ ｔｒｉａｌ ｏｆ ＡＢＴ−７５１， ａ ｎｏｖｅｌ ｍｉｃｒｏｔｕｂｌｉｎ Ｉｎｈｉｂｉｔｏｒ", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, 200211, Ｖｏｌ．３８, ｐ．Ｓ４２, GB, ＰＥＲＧＡＭＯＮ ＰＲＥＳＳ
JPN6010029038, ＫＯＹＡＮＡＧＩ， Ｎ．， ｅｔ ａｌ．, "Ｉｎ Ｖｉｖｏ Ｔｕｍｏｒ Ｇｒｏｗｔｈ Ｉｎｈｉｂｉｔｉｏｎ Ｐｒｏｄｕｃｅｄ ｂｙ ａ Ｎｏｖｅｌ Ｓｕｌｆｏｎａｍｉｄｅ， Ｅ７０１０， ａｇａｉｎｓｔ Ｒｏｄｅｎｔ ａｎｄ Ｈｕｍａｎ Ｔｕｍ", ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 19940401, Ｖｏｌ．５４， Ｎｏ．７, ｐ．１７０２−１７０６
JPN6010029041, ＦＵＮＡＨＡＳＨＩ， Ｙ．， ｅｔ ａｌ．, "Ｅｆｆｅｃｔ ｏｆ Ｅ７０１０ ｏｎ ｌｉｖｅｒ ｍｅｔａｓｔａｓｉｓ ａｎｄ ｌｉｆｅ ｓｐａｎ ｏｆ ｓｙｎｇｅｎｅｉｃ Ｃ５７ＢＬ／６ ｍｉｃｅ ｂｅａｒｉｎｇ ｏｒｔｈｏｔｏｐｉｃａｌｌｙ ｔ", Ｃａｎｅｒ Ｃｈｅｍｏｔｈｅｒａｐｙ ａｎｄ Ｐｈａｒｍａｃｏｌｇｙ, 200102, Ｖｏｌ．４７， Ｎｏ．２, ｐ．１７９−１８４
JPN6010029048, ＨＡＹＡＫＡＷＡ， Ｋ．， ｅｔ ａｌ．, "ＣＯＬＬＡＢＯＲＡＴＩＶＥ ＷＯＲＫ ＴＯ ＥＶＡＬＵＡＴＥ ＴＯＸＩＣＩＴＹ ＯＮ ＭＡＬＥ ＲＥＰＲＯＤＵＣＴＩＶＥ ＯＲＧＡＮＳ ＢＹ ＲＥＰＥＡＴＥＤ ＤＯＳＥ ＳＴＵＤＩＥＳ ＩＮ ＲＡＴＳ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｔｏｘｉｃｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ, 2000, Ｖｏｌ．２５， Ｓｐｅｃｉａｌ Ｉｓｓｕｅ, ｐ．１７３−１７８
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura