Title:
マイコラクトン遺伝子座:新規ポリケチド製造のためのアッセンブリーライン、治療的および防御的使用法
Document Type and Number:
Japanese Patent JP2007511218
Kind Code:
A
Abstract:
The present invention relates to Mycobacterium ulcerans virulence plasmid, pMUM001 and particularly to a cluster of genes carried by this plasmid that encode polyketide synthases (PKSs) and polyketide-modifying enzymes necessary and sufficient for mycolactone biosynthesis. More particularly this invention is directed to novel purified or isolated polypeptides, the polynucleotides encoding such polypeptides, processes for production of such polypeptides, antibodies generated against these polypeptides, the use of such polynucleotides and polypeptides in Diagnostic methods, kits, vaccines, therapy and for the production of mycolactone derivatives or novel polyketides by combinatorial synthesis.
Inventors:
Steiner Timothy Paul
Cole Stewart Thomas
Reed Ray Peter Francis
Small Pamela Long Claus
Davis Joan Case
Jenkin Grant Adam
Haydock Stephan Frederick
Johnson Paul
Cole Stewart Thomas
Reed Ray Peter Francis
Small Pamela Long Claus
Davis Joan Case
Jenkin Grant Adam
Haydock Stephan Frederick
Johnson Paul
Application Number:
JP2006538998A
Publication Date:
May 10, 2007
Filing Date:
November 15, 2004
Export Citation:
Assignee:
Institute Pasteur
University of Tennessee
Monash University
Austin university
Biotika technology
University of Tennessee
Monash University
Austin university
Biotika technology
International Classes:
C12N15/09; A61K39/00; A61P31/04; C07K16/40; C12N1/21; C12N9/00; C12N15/52; C12P7/24; C12P17/08; C12Q1/68; G01N33/50; G01N33/53; G01N33/569; C12P21/08
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi