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Patent Searching and Data


Title:
安定な成長ホルモン液体製剤
Document Type and Number:
Japanese Patent JP2007516274
Kind Code:
A
Abstract:
The present invention is directed to stable liquid growth hormone formulations that remain stable after physical agitation, and after exposure to one or more freeze-thaw events. Formulations of the present invention can be stored long term at a variety of temperatures, even frozen. In the present invention, a combination of buffer and stabilizing agents, including a non-ionic surfactant (e.g., polysorbate 20), a polymer stabilizer (e.g., polyethylene glycol), and other optional stabilizers combine to provide unexpected stability to aqueous formulations of a growth hormone (e.g., human growth hormone).

Inventors:
アドヴァイト バドゥカー
サンディープ ネマ
マンプリート ワドゥーワ
Application Number:
JP2006546366A
Publication Date:
June 21, 2007
Filing Date:
December 13, 2004
Export Citation:
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Assignee:
ファルマシア コーポレーション
International Classes:
A61K38/27; A61K9/00; A61K47/00; A61K47/02; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/26; A61K47/34; A61P5/06; A61P19/10; A61P43/00
Domestic Patent References:
JP2000504696A2000-04-18
JP2001517635A2001-10-09
JPH07509719A1995-10-26
JP2000508665A2000-07-11
Foreign References:
WO2002017957A12002-03-07
WO1997014430A11997-04-24
US5358708A1994-10-25
US5272135A1993-12-21
Attorney, Agent or Firm:
室伏 良信