Title:
HIVgp41HR2由来の合成ペプチド、およびヒト免疫不全ウイルスの伝播を阻止する治療におけるその使用
Document Type and Number:
Japanese Patent JP2007517522
Kind Code:
A
Abstract:
Provided are synthetic peptides based on a native sequence of HIV gp41 HR2 except that the synthetic peptides have a plurality of amino acid replacements comprising (a) a helix-promoting amino acid, or (b) a combination of helix-promoting amino acids, and charged amino acids introduced to form ion pairs in the synthetic peptide; wherein the synthetic peptides demonstrate an unexpected, improved biological activity, as compared to a peptide having an amino acid sequence without the plurality of amino acid substitutions. Also provided are polynucleotides encoding synthetic peptide, and methods of using these synthetic peptides in inhibition of, or as compositions to inhibit, transmission of HIV to a target cell.
Inventors:
Del Medico, Marie, Kay.
Dwyer, john
Dwyer, john
Application Number:
JP2006549305A
Publication Date:
July 05, 2007
Filing Date:
December 21, 2004
Export Citation:
Assignee:
Trimellis, Incorporated
International Classes:
C12N15/09; A61K38/00; A61K38/16; A61K45/00; A61P31/18; C07H19/00; C07H21/04; C07K14/00; C07K14/155; C07K14/16; C07K19/00
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita