Title:
補体活性を阻害することによる同種移植片の生存の延長
Document Type and Number:
Japanese Patent JP2007537299
Kind Code:
A
Abstract:
An antibody specific to C5, which inhibits the cleavage of C5, for use in prolonging survival of an allograft in a recipient mammal, wherein said antibody to C5 is to be administered chronically and said antibody to C5 is administered in conjunction with more than one immunosuppressive drug.
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Inventors:
Rotor, Russell Pee.
One, Hao
Zon, Zen
One, Hao
Zon, Zen
Application Number:
JP2007513459A
Publication Date:
December 20, 2007
Filing Date:
May 16, 2005
Export Citation:
Assignee:
Alexion Pharmaceuticals, Incorporated
THE UNIVERSITY OF WESTERN ONTARIO
THE UNIVERSITY OF WESTERN ONTARIO
International Classes:
A61K45/06; A61K31/675; A61K38/00; A61K39/395; A61P37/06; A61P43/00; C07K16/18
Domestic Patent References:
| JPH08501773A | 1996-02-27 | |||
| JPH10500289A | 1998-01-13 |
Foreign References:
| WO1992010205A1 | 1992-06-25 |
Other References:
JPN6011003371; ＷＡＮＧ，Ｈ． ｅｔ ａｌ: 'Ｃｏｍｐｌｅｍｅｎｔ ｉｎｈｉｂｉｔｉｏｎ ｗｉｔｈ ａｎ ａｎｔｉ-Ｃ５ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｙ ｐｒｅｖｅｎｔｓ ｈｙｐｅｒａｃｕｔｅ ｒｅｊｅｃｔｉｏｎ ｉｎ ａ ｘｅｎｏｇｒａ' Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．６８， Ｎｏ．１１, 1999, ｐ．１６４３-５１
JPN6011050180; ＰＲＡＴＴ，Ｊ．Ｒ． ｅｔ ａｌ: 'Ａｌｌｏｇｒａｆｔ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅ ｗｉｔｈ ｓＣＲ１ ｉｎｔｅｒｖｅｎｔｉｏｎ' Ｔｒａｎｓｐｌ Ｉｍｍｕｎｏｌ Ｖｏｌ．４， Ｎｏ．１, 1996, ｐ．７２-５
JPN6011050181; ＳＣＨＭＩＤ，Ｒ．Ａ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔ ｏｆ ｓｏｌｕｂｌｅ ｃｏｍｐｌｅｍｅｎｔ ｒｅｃｅｐｔｏｒ ｔｙｐｅ １ ｏｎ ｒｅｐｅｒｆｕｓｉｏｎ ｅｄｅｍａ ａｎｄ ｎｅｕｔｒｏｐｈｉｌ ｍｉｇｒａｔｉｏｎ ａｆｔｅｒ ｌｕｎ' Ｊ Ｔｈｏｒａｃ Ｃａｒｄｉｏｖａｓｃ Ｓｕｒｇ Ｖｏｌ．１１６， Ｎｏ．１, 1998, ｐ．９０-７
JPN6011050182; ＶＡＫＥＶＡ，Ａ．Ｐ． ｅｔ ａｌ: 'Ｍｙｏｃａｒｄｉａｌ ｉｎｆａｒｃｔｉｏｎ ａｎｄ ａｐｏｐｔｏｓｉｓ ａｆｔｅｒ ｍｙｏｃａｒｄｉａｌ ｉｓｃｈｅｍｉａ ａｎｄ ｒｅｐｅｒｆｕｓｉｏｎ： ｒｏｌｅ ｏｆ ｔｈｅ ｔｅｒｍｉｎａｌ' Ｃｉｒｃｕｌａｔｉｏｎ Ｖｏｌ．９７， Ｎｏ．２２, 1998, ｐ．２２５９-６７
JPN5007008242; ＫＡＬＬＩＯ ＥＲＫＫＩ Ａ: 'Ｂｌｏｃｋａｄｅ ｏｆ ｃｏｍｐｌｅｍｅｎｔ ｉｎｈｉｂｉｔｓ ｏｂｌｉｔｅｒａｔｉｖｅ ｂｒｏｎｃｈｉｏｌｉｔｉｓ ｉｎ ｒａｔ ｔｒａｃｈｅａｌ ａｌｌｏｇｒａｆｔｓ' ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＲＥＳＰＩＲＡＴＯＲＹ ＡＮＤ ＣＲＩＴＩＣＡＬ ＣＡＲＥ ＭＥＤＩＣＩＮＥ Ｖ１６１ Ｎ４ ＰＡＲＴ １, 200004, Ｐ１３３２-１３３９
JPN6011050183; ＦＲＥＩ，Ｙ． ｅｔ ａｌ: 'Ｇｅｎｅｒａｔｉｏｎ ｏｆ ａ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｙ ｔｏ ｍｏｕｓｅ Ｃ５ ａｐｐｌｉｃａｔｉｏｎ ｉｎ ａｎ ＥＬＩＳＡ ａｓｓａｙ ｆｏｒ ｄｅｔｅｃｔｉｏｎ ｏｆ ａｎｔｉ-' Ｍｏｌ Ｃｅｌｌ Ｐｒｏｂｅｓ Ｖｏｌ．１， Ｎｏ．２, 1987, ｐ．１４１-９
JPN6011050180; ＰＲＡＴＴ，Ｊ．Ｒ． ｅｔ ａｌ: 'Ａｌｌｏｇｒａｆｔ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅ ｗｉｔｈ ｓＣＲ１ ｉｎｔｅｒｖｅｎｔｉｏｎ' Ｔｒａｎｓｐｌ Ｉｍｍｕｎｏｌ Ｖｏｌ．４， Ｎｏ．１, 1996, ｐ．７２-５
JPN6011050181; ＳＣＨＭＩＤ，Ｒ．Ａ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔ ｏｆ ｓｏｌｕｂｌｅ ｃｏｍｐｌｅｍｅｎｔ ｒｅｃｅｐｔｏｒ ｔｙｐｅ １ ｏｎ ｒｅｐｅｒｆｕｓｉｏｎ ｅｄｅｍａ ａｎｄ ｎｅｕｔｒｏｐｈｉｌ ｍｉｇｒａｔｉｏｎ ａｆｔｅｒ ｌｕｎ' Ｊ Ｔｈｏｒａｃ Ｃａｒｄｉｏｖａｓｃ Ｓｕｒｇ Ｖｏｌ．１１６， Ｎｏ．１, 1998, ｐ．９０-７
JPN6011050182; ＶＡＫＥＶＡ，Ａ．Ｐ． ｅｔ ａｌ: 'Ｍｙｏｃａｒｄｉａｌ ｉｎｆａｒｃｔｉｏｎ ａｎｄ ａｐｏｐｔｏｓｉｓ ａｆｔｅｒ ｍｙｏｃａｒｄｉａｌ ｉｓｃｈｅｍｉａ ａｎｄ ｒｅｐｅｒｆｕｓｉｏｎ： ｒｏｌｅ ｏｆ ｔｈｅ ｔｅｒｍｉｎａｌ' Ｃｉｒｃｕｌａｔｉｏｎ Ｖｏｌ．９７， Ｎｏ．２２, 1998, ｐ．２２５９-６７
JPN5007008242; ＫＡＬＬＩＯ ＥＲＫＫＩ Ａ: 'Ｂｌｏｃｋａｄｅ ｏｆ ｃｏｍｐｌｅｍｅｎｔ ｉｎｈｉｂｉｔｓ ｏｂｌｉｔｅｒａｔｉｖｅ ｂｒｏｎｃｈｉｏｌｉｔｉｓ ｉｎ ｒａｔ ｔｒａｃｈｅａｌ ａｌｌｏｇｒａｆｔｓ' ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＲＥＳＰＩＲＡＴＯＲＹ ＡＮＤ ＣＲＩＴＩＣＡＬ ＣＡＲＥ ＭＥＤＩＣＩＮＥ Ｖ１６１ Ｎ４ ＰＡＲＴ １, 200004, Ｐ１３３２-１３３９
JPN6011050183; ＦＲＥＩ，Ｙ． ｅｔ ａｌ: 'Ｇｅｎｅｒａｔｉｏｎ ｏｆ ａ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｙ ｔｏ ｍｏｕｓｅ Ｃ５ ａｐｐｌｉｃａｔｉｏｎ ｉｎ ａｎ ＥＬＩＳＡ ａｓｓａｙ ｆｏｒ ｄｅｔｅｃｔｉｏｎ ｏｆ ａｎｔｉ-' Ｍｏｌ Ｃｅｌｌ Ｐｒｏｂｅｓ Ｖｏｌ．１， Ｎｏ．２, 1987, ｐ．１４１-９
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita