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Title:
2‐アミノ‐6‐アルキルアミノ‐4,5,6,7‐テトラヒドロベンゾチアゾール類の製造方法
Document Type and Number:
Japanese Patent JP2008503550
Kind Code:
A
Abstract:
The present invention relates to a process for preparing 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles (I) wherein the asterisk (*) represents an asymmetric carbon and R 1 is C 1 -C 6 alkyl; their enantiomers or mixtures thereof, their solvates, hydrates or pharmaceutically acceptable salts, comprising: (a) reacting a compound (II) with a secondary amine, optionally in the presence of an acid and a solvent 1, to form an enamine; (b) optionally removing said acid and said solvent 1, and then reacting said enamine with sulfur in the presence of a solvent 2; and (c) reacting the previously obtained compound with cyanamide to obtain the compound (I). Pramipexole, a compound with dopamine D-2 agonist activity, is among the compounds (I) and is useful for the treatment of Parkinson's disease and schizophrenia.

Inventors:
グスタボ、パスカル、コカ
ホルヘ、マルティン、フアレス
Application Number:
JP2007517312A
Publication Date:
February 07, 2008
Filing Date:
June 24, 2005
Export Citation:
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Assignee:
ラガクティブス,エス.エル.
International Classes:
C07D277/82; A61P25/16; A61P25/18; A61P43/00; C07C319/02; C07C323/30; C07D295/12; A61K31/428
Domestic Patent References:
JPS55133381A1980-10-17
JPS61155377A1986-07-15
JP2008540496A2008-11-20
Foreign References:
WO2004026850A12004-04-01
CA976170A1975-10-14
Attorney, Agent or Firm:
吉武 賢次
中村 行孝
紺野 昭男
横田 修孝