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Title:
新規バイオ開裂性リンカー
Document Type and Number:
Japanese Patent JP2008510795
Kind Code:
A
Abstract:
The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.

Inventors:
アッパラオ・サティアム
Application Number:
JP2007529100A
Publication Date:
April 10, 2008
Filing Date:
August 26, 2005
Export Citation:
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Assignee:
Apparao SATYAM
NICHOLAS PIRAMAL INDIA LIMITED
International Classes:
C07C323/12; A61K31/167; A61K31/195; A61K31/216; A61K31/23; A61K31/325; A61K31/337; A61K31/4015; A61K31/405; A61K31/415; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/42; A61K31/422; A61K31/435; A61K31/4422; A61K31/4523; A61K31/455; A61K31/4709; A61K31/495; A61K31/50; A61K31/53; A61K31/5513; A61K31/57; A61K31/616; A61K31/7072; A61K47/20; A61K47/22; A61K47/48; A61P3/02; A61P5/30; A61P9/12; A61P25/00; A61P25/08; A61P29/00; A61P35/00; A61P37/00; C07C323/25; C07C323/43; C07C323/52; C07D207/27; C07D207/46; C07D211/90; C07D213/80; C07D213/82; C07D231/10; C07D233/88; C07D235/04; C07D237/20; C07D261/08; C07D295/08; C07D309/10; C07D401/04; C07D401/12; C07D403/10; C07D405/12; C07D413/12; C07D495/04; C07H19/073; A61P31/04
Domestic Patent References:
JP2005510574A2005-04-21
JPH10504022A1998-04-14
JP2002522443A2002-07-23
JP2000511197A2000-08-29
JP2006518712A2006-08-17
JP2003507438A2003-02-25
JP2001520670A2001-10-30
JPH03161490A1991-07-11
JPH02111731A1990-04-24
Foreign References:
WO2003014072A12003-02-20
WO2003040104A12003-05-15
WO2004039771A12004-05-13
WO2004069159A22004-08-19
US20030044845A12003-03-06
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WO1986004898A11986-08-28
WO2003078416A12003-09-25
WO1999058152A11999-11-18
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Other References:
JPN6011033594; MICHAEL,K. et al: 'Enhanced RNA binding of dimerized amino glycosides' Bioorganic & Medicinal Chemistry Vol.7, No.7, 1999, p.1361-1371
JPN6011033595; ANNAERT,P. et al: 'Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)a' Pharmaceutical Research Vol.15, No.2, 1998, p.239-245
JPN6011033596; POSNER,G.H. et al: 'Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro' Bioorganic & Medicinal Chemistry Vol.5, No.7, 1997, p.1257-1265
JPN6011033597; GIRARDET,J. et al: 'Synthesis and antitumor properties of some neutral triesters of 5-fluoro-2'-deoxyuridine 5'-monophos' Nucleosides & Nucleotides Vol.14, No.3-5, 1995, p.645-7
JPN5003023556; ICHIKAWA, M.: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS V11 N13, 2001, P1769-1773
Attorney, Agent or Firm:
田中 光雄
山崎 宏
元山 忠行
冨田 憲史